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215 results for “patient history”
Data from: 1970s and 'Patient 0' HIV-1 genomes illuminate early HIV/AIDS history in North America
The emergence of HIV-1 group M subtype B in North American men who have sex with men was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US) throughout the 1970s1, 2 and an even older presence in the Caribbean2. However, these temporal and geographical inferences, based upon partial HIV-1 genomes that postdate the recognition of AIDS in 1981, remain contentious3, 4 and the earliest movements of the virus within the US are unknown. We serologically screened >2,000 1970s serum samples and developed a highly sensitive approach for recovering viral RNA from degraded archival samples. Here, we report eight coding-complete genomes from US serum samples from 1978–1979—eight of the nine oldest HIV-1 group M genomes to date. This early, full-genome 'snapshot' reveals that the US HIV-1 epidemic exhibited extensive genetic diversity in the 1970s but also provides strong evidence for its emergence from a pre-existing Caribbean epidemic. Bayesian phylogenetic analyses estimate the jump to the US at around 1970 and place the ancestral US virus in New York City with 0.99 posterior probability support, strongly suggesting this was the crucial hub of early US HIV/AIDS diversification. Logistic growth coalescent models reveal epidemic doubling times of 0.86 and 1.12 years for the US and Caribbean, respectively, suggesting rapid early expansion in each location3. Comparisons with more recent data reveal many of these insights to be unattainable without archival, full-genome sequences. We also recovered the HIV-1 genome from the individual known as 'Patient 0' (ref. 5) and found neither biological nor historical evidence that he was the primary case in the US or for subtype B as a whole. We discuss the genesis and persistence of this belief in the light of these evolutionary insights.
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2
ClinicalTrials.gov study NCT04478981. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.
Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Active Disease
ClinicalTrials.gov study NCT01753401. IPD Sharing: NO. Countries: 1. Publications: 1.
The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise
ClinicalTrials.gov study NCT01011712. IPD Sharing: YES. Countries: 1. Publications: 3.
A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP)
ClinicalTrials.gov study NCT01419028. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants - Observational Study
ClinicalTrials.gov study NCT06805734. IPD Sharing: YES. Countries: 1. Publications: 3.
The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope
ClinicalTrials.gov study NCT04972123. IPD Sharing: NO. Countries: 1. Publications: 1.
A Natural History Study In Chinese Male Patients With Duchenne Muscular Dystrophy
ClinicalTrials.gov study NCT03760029. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis (PREDICTORS)
ClinicalTrials.gov study NCT02297373. IPD Sharing: UNDECIDED. Countries: 3. Publications: 1.
Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer
ClinicalTrials.gov study NCT00450424. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: 1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America
Open the record for dataset details and reuse information.
A Study to Assess Neuroendocrine Tumour (NET) Patients Currently Treated by Somatuline Autogel for History of Carcinoid Syndrome Associated With Episodes of Diarrhea
ClinicalTrials.gov study NCT01234168. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD)
ClinicalTrials.gov study NCT01668186. IPD Sharing: Not stated. Countries: 1. Publications: 8.
A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.
ClinicalTrials.gov study NCT04220268. IPD Sharing: NO. Countries: 1. Publications: 1.
Individual Placement and Support for Patients With Offending Histories
ClinicalTrials.gov study NCT02442193. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Natural History Study of Patients With Mucopolysaccharidosis Type IIIB (MPS IIIB, Sanfilippo Syndrome Type B)
ClinicalTrials.gov study NCT01509768. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Study of Aripiprazole in Patients With a History of Bipolar Disorder
ClinicalTrials.gov study NCT00036348. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Molecular Breast Imaging in Patients With a History of Bloody Nipple Discharge
ClinicalTrials.gov study NCT00566280. IPD Sharing: Not stated. Countries: 1. Publications: 0.
UNN-RADS Scale for Diagnosing Lymph Node Metastasis in Patients With History of Thyroid Cancer
ClinicalTrials.gov study NCT06124469. IPD Sharing: YES. Countries: 1. Publications: 5.
Liver Injury by Statins in Patients With History of Hepatitis B Virus Infection
ClinicalTrials.gov study NCT02808299. IPD Sharing: Not stated. Countries: 1. Publications: 8.
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Allen Brain Atlas
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OpenNeuro
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