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1,999 results for “patient positioning”
Data for "Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: a prospective cohort study"
<p>Data for "Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: a prospective cohort study"</p>
A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges
ClinicalTrials.gov study NCT02336451. IPD Sharing: YES. Countries: 17. Publications: 1.
A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours
ClinicalTrials.gov study NCT01578239. IPD Sharing: YES. Countries: 8. Publications: 4.
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.
ClinicalTrials.gov study NCT01844765. IPD Sharing: YES. Countries: 13. Publications: 3.
LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib
ClinicalTrials.gov study NCT01828112. IPD Sharing: UNDECIDED. Countries: 20. Publications: 2.
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors
ClinicalTrials.gov study NCT02684058. IPD Sharing: YES. Countries: 20. Publications: 4.
LDK378 in Patients With ALK Positive NSCLC Previously Treated With Alectinib.
ClinicalTrials.gov study NCT02450903. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thy
ClinicalTrials.gov study NCT04940052. IPD Sharing: YES. Countries: 11. Publications: 0.
Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibito
ClinicalTrials.gov study NCT01610284. IPD Sharing: YES. Countries: 29. Publications: 2.
OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure
ClinicalTrials.gov study NCT02654587. IPD Sharing: NO. Countries: 10. Publications: 1.
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
ClinicalTrials.gov study NCT02667821. IPD Sharing: YES. Countries: 1. Publications: 13.
A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)
ClinicalTrials.gov study NCT00471497. IPD Sharing: YES. Countries: 35. Publications: 8.
COVID-19 Patient Positioning Pragmatic Trial
ClinicalTrials.gov study NCT04359797. IPD Sharing: YES. Countries: 1. Publications: 14.
Effectiveness of prone positioning in non-intubated ICU patients with moderate to severe ARDS
<p><strong>Data and R code from the paper</strong></p> <p><em><strong>Effectiveness of prone positioning in non-intubated ICU patients with moderate to severe ARDS</strong></em></p> <p>Authors:</p> <p>Manuel Taboada, Ph.D. Mariana González, M.D. Antía Álvarez, M.D., Irene González, M.D, Javier García, M.D., María Eiras. M.D., María Diaz Vieito, M.D., Alberto Naveira, M.D., Pablo Otero, M.D., Olga Campaña, M.D., Ignacio Muniategui, M.D., Ana Tubio, M.D., Jose Costa, M.D., Salomé Selas, M.D., Agustín Cariñena, M.D., Adrián Martínez, M.D., Sonia Veiras, M.D. Ph.D, Francisco Aneiros, M.D., Valentín Caruezo, M.D., Aurora Baluja, M.D. Julian Alvarez, Ph.D<br> <br> <strong>Background</strong>:<br> In the treatment for severe ARDS from COVID-19, the WHO recommends prone positioning (PP) during mechanical ventilation for periods of 12-16 hours per day to potentially improve oxygenation and survival. In this prospective observational study we evaluated the ability of long PP sessions to improve oxygenation in awake ICU patients with moderate or severe ARDS due to COVID-19.</p> <p><strong>Methods</strong>:<br> The study was approved by the ethics committee of Galicia (code No. 2020-188), and all patients provided informed consent. In this case series, awake patients with moderate or severe ARDS by COVID-19 admitted to the ICU at University Hospital of Santiago from March 21 to April 5, 2020 were prospectively analyzed. Patients were instructed to remain in PP as long as possible and not stop until the they felt too tired to maintain that position. If needed, light sedation was administered. The following information were collected: StO2 and blood gases (PaO2, PaO2/FiO2, PaCO2, pH) in ICU admission, number and duration of PP sessions, StO2 and blood gases before, during and following a PP session, need of mechanical ventilation, duration of ICU admission and ICU outcome. Linear mixed effects models (LMM) were adjusted to estimate changes of oxygenation parameters from baseline,. Patients were added as a random effect to account for inter-patient random variability in their own baseline measurements.</p> <p><strong>Results</strong>:<br> Seven patients with moderate or severe ARDS by COVID-19 were included. All patients received at least one PP session. A total of 16 PP sessions were performed in the 7 patients during the period study. The median duration of PP sessions was 10 hours. For PP sessions of more than 4 hours, dexmedetomidine was used for sedation. Oxygenation increased in all sixteen sessions performed in the seven patients. Prone positioning was associated to a net increase from baseline in PaO2, PaO2/FiO2 and StO2 (65, mmHg 110 and 2.6% respectively) PaO2/FiO2 increased during PP (Δ PaO2/FiO2 110.42 mmHg [28.173; 192.67]) and after PP (37.75 [-1.57; 77.07] compared with previous supine position (baseline PaO2FiO2 median-IQR97.8 [97.2 – 99.4]). Two patients required intubation. Six patients were discharged from the ICU and one remains on mechanical ventilation.</p> <p><strong>Conclusions</strong>:<br> We found that PP improved oxygenation and may avoid intubation in ICU patients with COVID-19 and moderate or severe ARDS. PP was relatively well tolerated in our patients. and may be a simple strategy to improve oxygenation trying to reduce patients in mechanical ventilation and the length of stay in the ICU, especially in the COVID-19 pandemic.</p> <p><strong>GitHub repository</strong>:</p> <p>https://github.com/medicalc/prone_sars</p>
Pertuzumab and Trastuzumab as Neoadjuvant Treatment in Patients With HER2-Positive Breast Cancer
ClinicalTrials.gov study NCT01937117. IPD Sharing: NO. Countries: 1. Publications: 2.
T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 Positive
ClinicalTrials.gov study NCT02111850. IPD Sharing: NO. Countries: 1. Publications: 3.
A Retrospective Observational Study of Patients With Early-stage HER2-positive Breast Cancer, Treated With Neratinib
ClinicalTrials.gov study NCT05599334. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT01625234. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors
ClinicalTrials.gov study NCT02228382. IPD Sharing: YES. Countries: 8. Publications: 5.
Enzalutamide for Patients With Androgen Receptor Positive Salivary Cancers
ClinicalTrials.gov study NCT02749903. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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