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28 results for “phosphatidylserine”
The Efficacy of Phosphatidylserine-Omega3 in Elderly With Age Associated Memory Impairment
ClinicalTrials.gov study NCT00437983. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Efficacy and Safety of Phosphatidylserine-Omega3 in Children With Attention-Deficit/ Hyperactivity Disorder
ClinicalTrials.gov study NCT00418184. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementary data for "Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems"
<p>Supplementary data for the manuscript entitled "Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems".</p>
Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake
<p>Supporting molecular dynamics (MD) files for the manuscript with the same title. It includes three parts: MD initial files, trajectory files with the membrane and solvent water stripped, and an example binding free energy calculation setting file using Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) method with an implicit membrane model.</p> <p>The MD initial files include MD parameters (folder 0_mdin) and specific topology (.parm7), initial structure (.rst7), and structural restraint files (.rest) in the corresponding folder for each simulation.</p> <p>The trajectory files include the topology files with membrane and solvent water stripped (.rst7) and 50-snapshot (4 ns interval) coordinate files (.nc) for each MD run.</p> <p>The MM-PBSA setting file (.in) is supposed to be used as the input of the MMPBSA.py utility of the AMBER simulation suite.</p>
Efficacy of Phosphatidylserine Enriched With n-3 PUFA Supplementation on ADHD in Children With Epilepsy
ClinicalTrials.gov study NCT02348073. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Supplementation of Phosphatidylserine (PS) and n-3 Long Chain Fatty Acids (EPA, DHA) in Children With ADHD
ClinicalTrials.gov study NCT00382616. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine in Healthy Children Aged 8 to 12 Years
ClinicalTrials.gov study NCT05177978. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
<p>Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses, have an established role in this process. While the microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized as key players, the neuronal molecular components that specify synapses to be eliminated are still undefined. Here, we show that exposed phosphatidylserine (PS) represents a neuronal "eat-me" signal involved in microglial-mediated pruning. In hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed PS using Annexin V or through microglial loss of TREM2. In vivo, PS exposure at both hippocampal and retinogeniculate synapses and engulfment of PS-labeled material by microglia occurs during established developmental periods of microglial-mediated synapse elimination. Mice deficient in C1q, which fail to properly refine retinogeniculate connections, have elevated presynaptic PS exposure and reduced PS engulfment by microglia. These data provide mechanistic insight into microglial-mediated synapse pruning and identify a novel role of developmentally regulated neuronal PS exposure that is common among developing brain structures.</p>
The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment
ClinicalTrials.gov study NCT00736034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phosphatidylserine exposure promotes increased adhesion in Dictyostelium Copine A mutants
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Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity
GEO Series GSE274652. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Phosphatidylserine clustering by membrane receptors triggers LC3-associated phagocytosis
GEO Series GSE299655. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Tafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
GEO Series GSE107045. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell Transcriptional Analysis of Murine Mesenteric Lymph Nodes Following Oral Lyso-phosphatidylserine Nanoparticle Administration Reveals Cellular Heterogeneity in Tolerance Features
GEO Series GSE302907. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
GEO Series GSE308521. Homo sapiens. 12 samples. Type: Other; Expression profiling by high throughput sequencing.
Phosphatidylserine Improves Cognitive Function in the Elderly
ClinicalTrials.gov study NCT04920305. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Consumption of Phosphatidylserine on the Cognitive Function
ClinicalTrials.gov study NCT05962008. IPD Sharing: NO. Countries: 1. Publications: 0.
Investigating a Phosphatidylserine Based Dietary Approach for the Management of Mild Cognitive Impairment
ClinicalTrials.gov study NCT02211560. IPD Sharing: Not stated. Countries: 2. Publications: 0.
The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia
ClinicalTrials.gov study NCT02276716. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross presentation
GEO Series GSE232108. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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