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Dataset results
18 results for “phosphoinositides”
Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes
<p>We report all-atom molecular dynamics simulations of physiologically composed asymmetric bilayers containing phosphoinositides in the presence of monovalent and divalent cations. We have characterized the molecular mechanism by which these divalent cations interact with phosphoinositides. Calcium desolvates more readily, consistent with single-molecule calculations, and forms a network of ionic-like bonds that serve as a "molecular glue'' that allows a single ion to coordinate with up to three phosphatidylinositol-(4,5)-bisphosphate lipids. The phosphatidylinositol-(3,5)-bisphosphate isomer shows no such effect and neither does PI(4,5)P2 in the presence of Mg. The resulting network of Ca-mediated lipid-lipid bonds grows to span the entire simulation space and therefore has implications for the lateral distribution of phosophoinositides in the bilayer. We observe context-specific differences in lipid diffusion rates, lipid surface densities, and bilayer structure. The molecular-scale delineation of ion-lipid arrangements reported here provides insight into similar nanocluster formation induced by peripheral proteins to regulate the formation of functional signaling complexes on the membrane.</p>
In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism
<p>Raw data of the publication "In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism"</p>
"The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate" -- MD Trajectories
<p>MD trajectories and related files for the simulations related to the work: "The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate" by Araya-Secchi R., Bugge K. and Seiffert et al. </p> <p>This dataset contains:</p> <p>1) Trajectories of CG-MD simulations of PRLR-LID1 in lipid bilayers with POPC on the upper leaflet and two compositions on the lower leaflet: POPC:POPS:PIP2 80:10:10 and 90:5:5. These simulations were performed using the open beta version of the Martini 3 (3.b3.2) force field modified to increase the strength of Protein-water interactions by 10% (m3pws10).</p> <p>2) Trajectory of the all-atom simulation of the JAK2-FERM-SH2 + PRLR-LID1 complex in solution.</p> <p>3) Trajectories of CG-MD simulations of the JAK2-FERM-SH2 + PRLR-LID1 complex near a POPC:POPS (70:30) bilayer (8 initial conformations) performed using the Martini2 forcefield.</p> <p>4) Trajectories of CG-MD simulations of the JAK2-FERM-SH2 + PRLR-LID1 complex near a POPC:POPS:PIP2 (80:10:10) bilayer (16 initial conformations) performed using the Martini2 forcefield.</p>
Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome
ClinicalTrials.gov study NCT03383380. IPD Sharing: NO. Countries: 1. Publications: 6.
Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes
Open the record for dataset details and reuse information.
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival
GEO Series GSE54309. Mus musculus. 6 samples. Type: Expression profiling by array.
New Biomarker-based Strategy to Screen and Monitor for Activated Phosphoinositide 3-kinase Δ Syndrome
ClinicalTrials.gov study NCT06694363. IPD Sharing: NO. Countries: 1. Publications: 0.
Glycolysis Promotes Phosphoinositide 3-Kinase Signaling In Support of T Helper 17 Cell-Mediated Autoimmunity
GEO Series GSE164959. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transgenic soybeans (Glycine max) secreting Phosphoinositide-3-phosphate binding proteins show enhanced resistance to oomycete pathogen Phytophthora sojae
GEO Series GSE201739. Glycine max. 36 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast
GEO Series GSE125301. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
MiR-1287-5p has inhibitory effects on breast cancer growth mediated by interaction with phosphoinositide 3-kinase CB
GEO Series GSE103218. Homo sapiens; synthetic construct. 6 samples. Type: Non-coding RNA profiling by array.
MiR-1287-5p has inhibitory effects on breast cancer growth mediated by interaction with phosphoinositide 3-kinase CB (miR-1287-5p overexpression study)
GEO Series GSE103388. Homo sapiens. 6 samples. Type: Expression profiling by array.
The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output
GEO Series GSE66353. Mus musculus. 18 samples. Type: Expression profiling by array.
Targeting the Phosphoinositide 3-Kinase p110α Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer
GEO Series GSE40564. Homo sapiens. 9 samples. Type: Expression profiling by array.
Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling
GEO Series GSE211598. Homo sapiens. 6 samples. Type: Expression profiling by array.
Regulation of the Hippo pathway by phosphoinositol transfer protein (PITP) and phosphoinositides
GEO Series GSE198890. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification and characterization of a novel StAR-related lipid transfer protein in Entamoeba histolytica that shuttles phosphoinositides between the nucleus and the cytoplasm: role in growth, stres
GEO Series GSE287946. Entamoeba histolytica. 6 samples. Type: Expression profiling by high throughput sequencing.
Cardiac hypertrophy related to the phosphoinositide 3-kinase signaling pathway
GEO Series GSE558. Mus musculus. 9 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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