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6 results for “physiological dysregulation”
Data from: Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees
<p>Lifestyle has widespread effects on human health and aging. Prior results from chimpanzees, one of the closest evolutionary relatives of humans, indicate that these lifestyle effects may also be shared with other species, as semi-free-ranging chimpanzees fed a naturalistic diet show healthier values in several specific health biomarkers, compared with their sedentary, captive counterparts. Here, we examined how lifestyle factors associated with different environments affect rates of physiological aging in closely related chimpanzees (<em>Pan troglodytes</em>). We compared physiological dysregulation, an index of biological aging, in semi-free-ranging chimpanzees in an African sanctuary versus captive chimpanzees in US laboratories. If the rate of aging is accelerated by a high-calorie diet and sedentism, we predicted greater age-related dysregulation in the laboratory populations. Conversely, if the costs of a wild lifestyle accelerate aging, then semi-free-ranging chimpanzees at the sanctuary, whose environment better approximates the wild, should show greater age-related dysregulation. We further tested whether dysregulation differed based on sex or body system, as in humans. We found that semi-free-ranging chimpanzees showed lower overall dysregulation, as well as lower age-related change in dysregulation, than laboratory chimpanzees. Males experienced lower dysregulation in both contexts, and the two populations exhibited distinct aging patterns based on the body system. Our results support the conclusion that naturalistic living conditions result in healthier aging in chimpanzees. These data provide support for the proposal that lifestyle effects on human health and aging are conserved from deeper into our evolutionary history.</p>
Data from: Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees
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Tsimane physiological dysregulation data
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Data from: A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
1. The body condition of free-ranging animals affects their response to stress, decisions, ability to fulfil vital needs and, ultimately, fitness. However, this key attribute in ecology remains difficult to assess, and there is a clear need for more integrative measures than the common univariate proxies. 2. We propose a systems biology approach that positions individuals along a gradient from a 'normal/optimal' to 'abnormal/suboptimal' physiological state based on Mahalanobis distance computed from physiological biomarkers. We previously demonstrated the validity of this approach for studying ageing in humans; here, we illustrate its broad potential for ecological studies. 3. As an example, we used biomarker data on shorebirds and found that birds with an abnormal condition had a lower maximal thermogenic capacity and higher scores of inflammation, with important implications for their ecology and health. Moreover, Mahalanobis distance captured a signal of condition not detected by the individual biomarkers. 4. Overall, our results on birds and humans show that individuals with abnormal physiologies are indeed in worse condition. Moreover, our approach appears not to be particularly sensitive to which set of biomarkers is used to assess condition. Consequently, it could be applied easily to existing ecological data sets. 5. Our approach provides a general, powerful way to measure condition that helps resolve confusion as to how to deal with complex interactions and interdependence among multiple physiological and condition measures. It can be applied directly to topics such as the effect of environmental quality on body condition, risks of health outcomes, mechanisms of adaptive phenotypic plasticity, and mechanisms behind long-term processes such as senescence.
Data from: A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
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Pogz deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology
GEO Series GSE144648. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.