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333 results for “pioglitazone”
Metabolic shift of chronic myeloid leukemia patients under Imatinib-Pioglitazone regimen and discontinuation_dataset
<p>The EDI-PIO (<strong>E</strong>studo de <strong>D</strong>escontinuação de <strong>I</strong>matinibe após<strong> Pio</strong>glitazona) is a single-center, longitudinal, prospective, phase 2, non-randomized, open, clinical trial (NCT02852486, August 2, 2016 retrospectively registered) for the discontinuation of imatinib after concomitant use of pioglitazone, being the first of its kind in a Brazilian population with chronic myeloid leukemia. Due to remaining of leukemic quiescent cells that are not affected by tyrosine kinase inhibitors, it has been suggested the use of pioglitazone, a PPARγ agonist, together with imatinib as a strategy for the maintenance of deep molecular response. The clinical benefit to this association is still controversial, and the metabolic alteration along this process remains unclear. Therefore, we applied a metabolomic protocol using high-resolution mass spectrometry to profile plasmatic metabolic response of a prospective cohort of 10 individuals under discontinuation of imatinib and pioglitazone protocol. By comparing patients under pioglitazone and imatinib treatment with imatinib monotherapy and discontinuation phase, we were able to annotate 41 and 36 metabolites, respectively. The metabolic alterations observed during Imatinib-Pioglitazone combined therapy are associated with an extensive lipid remodelling, with activation of β-oxidation pathway, in addition to the presence of markers that suggest mitochondrial dysfunction.</p>
Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)
ClinicalTrials.gov study NCT00868140. IPD Sharing: NO. Countries: 2. Publications: 1.
Pioglitazone to Treat Fatty Liver in Patients With HIV and Hepatitis C Infections
ClinicalTrials.gov study NCT00742326. IPD Sharing: NO. Countries: 1. Publications: 4.
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes
ClinicalTrials.gov study NCT01156597. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION -
ClinicalTrials.gov study NCT00637273. IPD Sharing: Not stated. Countries: 3. Publications: 8.
Pioglitazone Before Peginterferon and Ribavirin for Hepatitis C Infection in HIV/HCV-Coinfected Patients With Insulin Resistance
ClinicalTrials.gov study NCT00665353. IPD Sharing: Not stated. Countries: 1. Publications: 4.
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
ClinicalTrials.gov study NCT00994682. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Exercise and Pioglitazone for HIV-Metabolic Syndromes
ClinicalTrials.gov study NCT00639457. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Alogliptin Combined With Pioglitazone in Subjects With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT00286494. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease
ClinicalTrials.gov study NCT03011775. IPD Sharing: NO. Countries: 1. Publications: 1.
Pioglitazone for Heroin and for Nicotine Dependence
ClinicalTrials.gov study NCT01395797. IPD Sharing: YES. Countries: 1. Publications: 1.
Pioglitazone in Early Parkinson's Disease
ClinicalTrials.gov study NCT01280123. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Renal and Hormonal Effects of Pioglitazone
ClinicalTrials.gov study NCT01090752. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Pioglitazone on TIMP-3 and TACE in Type 2 Diabetes
ClinicalTrials.gov study NCT01223196. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT00225277. IPD Sharing: Not stated. Countries: 4. Publications: 3.
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone
ClinicalTrials.gov study NCT00763815. IPD Sharing: Not stated. Countries: 13. Publications: 1.
Treating Nonalcoholic Steatohepatitis With Pioglitazone
ClinicalTrials.gov study NCT00062764. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Use of Low Dose Pioglitazone to Treat Autosomal Dominant Polycystic Kidney Disease
ClinicalTrials.gov study NCT02697617. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of Alogliptin and With Pioglitazone in Patients With Type 2 Diabetes.
ClinicalTrials.gov study NCT00655863. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes
ClinicalTrials.gov study NCT00972283. IPD Sharing: Not stated. Countries: 12. Publications: 11.
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