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178 results for “platelet function”
Measuring platelet function: new strategies for precision medicine to prevent thrombosis - Prof Jon Gibbins (University of Reading)
<p>This video is the third talk from our two day Future Blood Testing: Challenges & Opportunities Event that took place on the 13/09/2022.</p> <p>Measuring platelet function: new strategies for precision medicine to prevent thrombosis - Prof Jon Gibbins (University of Reading).</p> <p>Bio: Jon Gibbins is Professor of Cell Biology within the School of Biological Sciences at the University and is Director of the Institute for Cardiovascular and Metabolic Research. He is a graduate of the University, obtaining a degree in Pathobiology with Chemistry in 1991 and a PhD in Molecular Endocrinology in 1995. Following a period of postdoctoral research at the Oxford University, he returned to Reading in 1998 as a lecturer. Jon has established an internationally leading research group that studies blood clotting, with a particular focus on the development of more effective clinical strategies for the prevention and treatment of heart attacks and strokes, and thrombosis associated with infection. Jon values greatly working in an active, engaging and successful school, in which all aspects of biology are represented, and he champions cross-disciplinary working to approach today’s most challenging and pressing questions in new ways. He believes strongly in widening participation and improving levels of equity, diversity and inclusion across our institution.</p> <p>Further details on this event can be found at: https://futurebloodtesting.org/event/13-14-09-2022/</p> <p>This video is an output from the Future Blood Testing Network which is funded by EPSRC under Grant Number EP/W000652/1</p> <p>YouTube Link: https://youtu.be/8vJZ_WO-dvk</p>
Effects of Recombinant Human Erythropoietin on Platelet Function in Patients With Acute Myocardial Infarction
ClinicalTrials.gov study NCT00367991. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.
ClinicalTrials.gov study NCT04400760. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events
ClinicalTrials.gov study NCT01586975. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Depression, Epinephrine, and Platelet Function
ClinicalTrials.gov study NCT00166114. IPD Sharing: Not stated. Countries: 1. Publications: 4.
IV Ketorolac on Platelet Function Post-Cesarean Delivery
ClinicalTrials.gov study NCT03805607. IPD Sharing: NO. Countries: 1. Publications: 7.
Effects of Pioglitazone on Platelet Function
ClinicalTrials.gov study NCT00861341. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Platelet Function in Resuscitated Patients
ClinicalTrials.gov study NCT02914795. IPD Sharing: NO. Countries: 1. Publications: 6.
The Effect of empagliFlozin on Platelet Function profilEs in diabetiC patienTs - The EFFECT Study.
ClinicalTrials.gov study NCT04342819. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
ClinicalTrials.gov study NCT02060838. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Primordial GATA6 macrophages function as extravascular platelets in sterile injury
<p>Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species like purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6<sup>+</sup> macrophages, which may play a similar role. It is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate towards injuries, however. Here, we show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury using primordial scavenger receptor (SRCR) domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue termed peritoneal adhesions.</p>
Data from: Peptides derived from cadherin juxtamembrane region inhibit platelet function
The juxtamembrane domains (JMD) of transmembrane proteins are rich in critical peptide sequences that participate in dynamic cell signaling events. Synthetic JMD peptides derived from cadherin cell adhesion proteins have previously been shown to modulate platelet function. In this study, we aimed to develop functional bioactive agents from bioinformatically-identified critical peptide sequences. We synthesized overlapping 12-15 amino acids peptides from E- and N-cadherin JMD and assessed their effect on platelet aggregation and platelet ATP secretion. Peptides derived from close to the membrane proximal region inhibit platelet function. Sequential deletion of amino acids from the N- and C-termini of the inhibitory E-cadherin peptides identified the short K756EPLLP763 motif as a critical bioactive sequence. Alanine scanning studies further identified that the dileucine (LL) motif and positively charged lysine (K) are crucial for peptide activity. Moreover, scrambled peptides failed to show any effect on platelet activity. We conclude that peptides derived from JMD of E-cadherin provide potential lead peptides for the development of anti-thrombotic agents and to enable further understanding of the role of cadherins in platelet function.
Precise Antiplatelet THerapy Guided by Platelet Aggregation Function in Ischemic STROKE（PATH-STROKE）
ClinicalTrials.gov study NCT06269432. IPD Sharing: NO. Countries: 1. Publications: 11.
Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing
ClinicalTrials.gov study NCT01456364. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Monitoring Platelet Function During Continuous Hemodialysis
ClinicalTrials.gov study NCT01837758. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Platelet Function in Resuscitated Patients-2
ClinicalTrials.gov study NCT03445546. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient
ClinicalTrials.gov study NCT01045785. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lipidomics and Functional Analyses of Platelets in Fabry Disease
ClinicalTrials.gov study NCT02649660. IPD Sharing: Not stated. Countries: 1. Publications: 7.
ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders
ClinicalTrials.gov study NCT00632242. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve
ClinicalTrials.gov study NCT02969070. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
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