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ShareScore release 0.9.0
Dataset results
6 results for “platinum complex”
Characterization of platinum(II) complexes exhibiting inhibitory activity against 20S Proteasome
<p><span>Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracene and heterocycle exhibited proteasome inhibitory activity. In the present study, the structure-activity relationships and characterization of these complexes were determined for elucidation of role of aromatic ligands. Lineweaver-Burk analysis revealed that the chemical structure of heterocyles affects binding mode of platinum complexes. Platinum complexes with anthracene and pyridine showed competitive inhibition although platinum complexes with antharcene and phenantholine showed non-competitive inhibition. The structure-activity relationships demonstrated that anthracene moiety play a crucial role for proteasome inhibitory activity. The platinum complexes with naphthalene or benzene exhibited lower inhibitory activities than the platinum complex with anthracene. The reactivity with N-acetyl cysteine varied according to the chemical structure of complexes. </span></p>
Characterization of platinum(II) complexes exhibiting inhibitory activity against 20S Proteasome
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X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect
GEO Series GSE314315. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome
GEO Series GSE249026. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of cancer stem cell self-renewal by a platinum(II) complex suppresses metastasis in gastrointestinal cancer
GEO Series GSE296719. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Pt-ttpy, a G-quadruplex binding platinum complex, induces telomere dysfunction and G-rich regions DNA damage
GEO Series GSE171450. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.