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67 results for “pleiotropy”
Estimates of molecular convergence reveal genes with intermediate pleiotropy underlying adaptive variation across teleost fish
<p>This dataset comprises raw sequence data, output of analyses, code used to reproduce the study, figures, and supplementary materials.</p> <p>Code and input files are in Datasets.zip</p> <p>Use the README to navigate this folder. </p> <p>Data to reproduce the CSUBST analysis are in the .tar.gz folder.</p> <p> </p> <p>For more information please check: </p> <p>https://github.com/agneeshbarua/Teleost_convergence</p>
Data from: Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks
<p>Many genes and signaling pathways within plant and animal taxa drive the expression of multiple organismal traits. This form of genetic pleiotropy instigates trade-offs among life-history traits if a mutation in the pleiotropic gene improves the fitness contribution of one trait at the expense of another. Whether or not pleiotropy gives rise to conflict among traits, however, likely depends on the resource costs and timing of trait deployment during organismal development. To investigate factors that could influence the evolutionary maintenance of pleiotropy in gene networks, we developed an agent-based model of co-evolution between parasites and hosts. Hosts comprise signaling networks that must faithfully complete a developmental program while also defending against parasites, and trait signaling networks could be independent or share a pleiotropic component as they evolved to improve host fitness. We found that hosts with independent developmental and immune networks were significantly more fit than hosts with pleiotropic networks when traits were deployed asynchronously during development. When host genotypes directly competed against each other, however, pleiotropic hosts were victorious regardless of trait synchrony because the pleiotropic networks were more robust to parasite manipulation, potentially explaining the abundance of pleiotropy in immune systems despite its contribution to life history trade-offs.</p>
Data from: Pleiotropy increases with gene age in six model multicellular eukaryotes
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Data from: Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks
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Heterozygote advantage and pleiotropy contribute to intraspecific color trait variability
<p><span>The persistence of intrapopulation phenotypic variation typically requires some form of balancing selection since drift and directional selection eventually erode genetic variation.</span> <span>Heterozygote advantage remains a classic explanation for the maintenance of genetic variation in the face of selection. However, examples of heterozygote advantage, other than those associated with disease resistance are rather uncommon. </span><span>Across most of its distribution, males of the aposematic moth Arctia plantaginis have two hindwing phenotypes determined by a heritable one locus-two allele polymorphism (genotypes: WW/Wy = white morph, yy = yellow morph). Using genotyped moths we show that the presence of one or two copies of the <em>yellow </em>allele affects several life-history traits. Reproductive output of both males and females, and female mating success are negatively affected by two copies of the <em>yellow </em>allele. Females carrying one <em>yellow </em>allele (i.e. Wy) have higher fertility, hatching success, and offspring survival than either homozygote, thus leading to strong heterozygote advantage. Our results indicate strong female contribution especially at the postcopulatory stage in maintaining the color polymorphism. The interplay between heterozygote advantage, <em>yellow </em>allele pleiotropic effect and morph-specific predation pressure may exert balancing selection on the color locus, suggesting that color polymorphism may be maintained through complex interactions between natural and sexual selection.</span></p>
Pleiotropy of UK Biobank metabolites
<p>Pleiotropy and genetic correlation are widespread features in GWAS, but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino acid catabolism, glycolysis, and ketone body metabolism in a subset of UK Biobank. We utilize the well-documented biochemistry jointly impacting these metabolites to analyze pleiotropic effects in the context of their pathways. Among the 213 lead GWAS hits, we find a strong enrichment for genes encoding pathway-relevant enzymes and transporters. We demonstrate that the effect directions of variants acting on biology between metabolite pairs often contrast with those of upstream or downstream variants as well as the polygenic background. Thus, we find that these outlier variants often reflect biology local to the traits. Finally, we explore the implications for interpreting disease GWAS, underscoring the potential of unifying biochemistry with dense metabolomics data to understand the molecular basis of pleiotropy in complex traits and diseases.</p>
Hormonal pleiotropy structures genetic covariance
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Pleiotropy of UK Biobank metabolites
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Heterozygote advantage and pleiotropy contribute to intraspecific color trait variability
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Data from: Precise colocalization of sorghum’s major chilling tolerance locus with Tannin1 due to tight linkage drag rather than antagonistic pleiotropy
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Data from: A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence
1. The environment can play an important role in the evolution of senescence because the optimal allocation between somatic maintenance and reproduction depends on external factors influencing life expectancy. 2. The aims of this study were to experimentally test whether environmental conditions during early life can shape senescence schedules, and if so, to examine whether variation among individuals or genotypes with respect to the degree of ageing differs across environments. 3. We tested life-history plasticity and quantified genetic effects on the pattern of senescence across different environments within a reaction norm framework by using an experiment on the three-spined stickleback (Gasterosteus aculeatus, Linnaeus) in which F1 families originating from a wild annual population experienced different temperature regimes. 4. Male sticklebacks that had experienced a more benign environment earlier in life subsequently reduced their investment in carotenoid-based sexual signals early in the breeding season, and consequently senesced at a slower rate later in the season, compared to those that had developed under harsher conditions. This plasticity of ageing was genetically determined. Both antagonistic pleiotropy and genetic variation in the rate of senescence were evident only in the individuals raised in the harsher environment. 5. The experimental demonstration of genotype-by-environment interactions influencing the rate of reproductive senescence provides interesting insights into the role of the environment in the evolution of life-histories. The results suggest that benign conditions weaken the scope for senescence to evolve, and that the dependence on the environment may maintain genetic variation under selection.
Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l−1) than women with genotypes without ApoE4 (120.49 pmol l−1), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.
Sexual signal loss, pleiotropy, and maintenance of a male reproductive polymorphism in crickets
<p>Pleiotropy between male signals and female preferences can facilitate evolution of sexual communication by maintaining coordination between the sexes. Alternatively, it can favor variation in the mating system, such as a reproductive polymorphism. It is unknown how common either of these scenarios are in nature. In Pacific field crickets (<i>Teleogryllus oceanicus</i>) on Kauai, Hawaii, a mutation (<i>flatwing</i>) that segregates as a single locus is responsible for the rapid loss of song production in males. We used outbred cricket colonies fixed for male wing morph to investigate whether homozygous <i>flatwing</i> and <i>normal-wing</i> (wild-type) females differ in responsiveness to male calling song and propensity to mate when paired with either a <i>flatwing</i> or <i>normal-wing</i> male in the presence or absence of courtship song. <i>Flatwing</i> females were less likely to mount a male than <i>normal-wing</i> females. Females of both genotypes showed a preference for <i>normal-wing</i> males and were more likely to mate in the presence of courtship song; n<i>ormal-wing </i>females<i> </i>were<i> </i>particularly likely to mate with song. Our results show that negative pleiotropy between obligate male silence and female mating behavior can constrain the evolution of sexual signal loss and contribute to the maintenance of a male reproductive polymorphism in the wild. </p>
Power study results files for manuscript "Testing pleiotropy vs. separate QTL in multiparental populations"
<p>Results files for power study in manuscript "Testing pleiotropy vs. separate QTL in multiparental populations" by F Boehm, E Chesler, B Yandell, and K Broman.</p>
Data set for the manuscript 'Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency'
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Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution
<p>The archives uploaded here include the code used to perform the evolutionary simulations as described in <em>Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution </em>authors: Martin,R. Tate, A. as well as the data that was used in the generation of the figures for that paper. Code requires the Julia programming language and necessary packages to run.</p>
Balancing selection in Pattern Recognition Receptor signalling pathways is associated with gene function and pleiotropy in a wild rodent
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Data from: Antagonistic selection and pleiotropy constrain the evolution of plant chemical defenses
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More than DNA methylation: does pleiotropy drive the complex pattern of evolution of Dnmt1?
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Sexual signal loss, pleiotropy, and maintenance of a male reproductive polymorphism in crickets
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.