Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
17
datasets available to search
ShareScore release 0.9.0
Dataset results
17 results for “polygenic selection”
Data From: Powerful detection of polygenic selection and environmental adaptation in US beef cattle
<p>GEMMA output containing summary statistics for generation proxy selection mapping (GPSM) and environmental GWAS (envGWAS) selection analyses from <br> Rowan et al. "Powerful detection of polygenic selection and environmental adaptation in US beef cattle" 2021<br> https://doi.org/10.1101/2020.03.11.988121 </p> <p>File names identify the analysis run, for example<br> "Gelbvieh_envgwas_desert_summary_stats.txt.gz"<br> Is the Gelbvieh dataset analyzed using the Desert ecoregion as the dependent variable <br> in a univariate envGWAS model. </p> <p>Files are formated according to GEMMA output.</p>
Data From: Polygenic basis and the role of genome duplication in adaptation to similar selective environments
Open the record for dataset details and reuse information.
Data from: Whole-genome resequencing reveals polygenic signatures of directional and balancing selection on alternative migratory life histories
Open the record for dataset details and reuse information.
Data and Code: No support for the genetic hypothesis of the Black-white achievement gap using polygenic scores and tests for divergent selection
<p>Data and Code for article "No support for the genetic hypothesis of the Black-white achievement gap using polygenic scores and tests for divergent selection"</p>
Data from: Population genomics of rapid evolution in natural populations: polygenic selection in response to power station thermal effluents
Background: Examples of rapid evolution are common in nature but difficult to account for with the standard population genetic model of adaptation. Instead, selection from the standing genetic variation permits rapid adaptation via soft sweeps or polygenic adaptation. Empirical evidence of this process in nature is currently limited but accumulating. Results: We provide genome-wide analyses of rapid evolution in two Fundulus heteroclitus populations subjected to recently elevated temperatures due to coastal power station thermal effluents. Bayesian and multivariate analyses of population genomic structure reveal a substantial portion of genetic variation that is most parsimoniously explained by selection at the site of thermal effluents. An FST outlier approach in conjunction with additional conservative requirements identify significant allele frequency differentiation that exceeds neutral expectations among exposed and closely related reference populations. Genomic variation patterns near these candidate loci reveal that individuals living near thermal effluents have rapidly evolved from the standing genetic variation through small allele frequency changes at many loci in a pattern consistent with polygenic selection on the standing genetic variation. Conclusions: While the ultimate trajectory of selection in these populations is unknown, our findings suggest that polygenic models of adaptation may play important roles in large, natural populations experiencing recent selection due to environmental changes that cause broad physiological impacts.
Data from: Population genomics of rapid evolution in natural populations: polygenic selection in response to power station thermal effluents
Open the record for dataset details and reuse information.
Data from: Recent natural selection causes adaptive evolution of an avian polygenic trait
We used extensive data from a long-term study of great tits (Parus major) in the United Kingdom and Netherlands to better understand how genetic signatures of selection translate into variation in fitness and phenotypes. We found that genomic regions under differential selection contained candidate genes for bill morphology and used genetic architecture analyses to confirm that these genes, especially the collagen gene COL4A5, explained variation in bill length. COL4A5 variation was associated with reproductive success, which, combined with spatiotemporal patterns of bill length, suggested ongoing selection for longer bills in the United Kingdom. Last, bill length and COL4A5 variation were associated with usage of feeders, suggesting that longer bills may have evolved in the United Kingdom as a response to supplementary feeding.
Data from: Optimizing genomic selection for blight resistance in American chestnut backcross populations: a tradeoff with American chestnut ancestry implies resistance is polygenic
Open the record for dataset details and reuse information.
Data from: Detecting genotypic changes associated with selective mortality at sea in Atlantic salmon: polygenic multi-locus analysis surpasses genome scan
Open the record for dataset details and reuse information.
Data from: Recent natural selection causes adaptive evolution of an avian polygenic trait
Open the record for dataset details and reuse information.
A population-genomic approach for estimating selection on polygenic traits in heterogeneous environments
Open the record for dataset details and reuse information.
Polygenic selection within a single generation leads to subtle divergence among ecological niches
<p>Selection on standing genetic variation may be effective enough to allow for adaptation to distinct niche environments within a single generation. Minor allele frequency changes at multiple, redundant loci of small effect can produce remarkable phenotypic shifts. Yet, demonstrating rapid adaptation via polygenic selection in the wild remains challenging. Here we harness natural replicate populations that experience similar selection pressures and harbor high within-, yet negligible among-population genetic variation. Such populations can be found among the teleost Fundulus heteroclitus which inhabits marine estuaries characterized by high environmental heterogeneity. We identify 10,861 single nucleotide polymorphisms in F. heteroclitus that belong to a single, panmictic population yet reside in environmentally distinct niches (one coastal basin and three replicate tidal ponds). By sampling at two time-points within a single generation we quantify both allele frequency change within as well as spatial divergence among niche subpopulations. We observe few individually significant allele frequency changes yet find that the number of moderate changes exceeds the neutral expectation by 10-100%. We find allele frequency changes to be significantly concordant in both direction and magnitude among all niche subpopulations, suggestive of parallel selection. In addition, within-generation allele frequency changes generate subtle but significant divergence among niches, indicative of local adaptation. Although we cannot distinguish between selection and genotype-dependent migration as drivers of within-generation allele frequency changes, the trait/s determining fitness and/or migration likelihood appear to be polygenic. In heterogeneous environments, polygenic selection and polygenic, genotype-dependent migration offer conceivable mechanisms for within-generation, local adaptation to distinct niches.</p>
Data from: RAD-sequencing reveals within-generation polygenic selection in response to anthropogenic organic and metal contamination in North Atlantic Eels
Measuring the effects of selection on the genome imposed by human-altered environment is currently a major goal in ecological genomics. Given the polygenic basis of most phenotypic traits, quantitative genetic theory predicts that selection is expected to cause subtle allelic changes among covarying loci rather than pronounced changes at few loci of large effects. The goal of this study was to test for the occurrence of polygenic selection in both North Atlantic eels (European Eel, Anguilla anguilla and American Eel, A. rostrata), using a method that searches for covariation among loci that would discriminate eels from "control" vs. "polluted" environments and be associated with specific contaminants acting as putative selective agents. RAD-seq libraries resulted in 23,659 and 14,755 filtered loci for the European and American Eels respectively. A total of 142 and 141 covarying markers discriminating European and American Eels from "control" vs. "polluted" sampling localities were obtained using the Random Forest algorithm. Distance-based redundancy analyses (db-RDAs) were used to assess the relationships between these covarying markers and concentration of 34 contaminants measured for each individual eel. PCB153, 4'4'DDE and selenium were associated with covarying markers for both species, thus pointing to these contaminants as major selective agents in contaminated sites . Gene enrichment analyses suggested that sterol regulation plays an important role in the differential survival of eels in "polluted" environment. This study illustrates the power of combining methods for detecting signals of polygenic selection and for associating variation of markers with putative selective agents in studies aiming at documenting the dynamics of selection at the genomic level, and particularly so in human altered environments.
Polygenic selection within a single generation leads to subtle divergence among ecological niches
Open the record for dataset details and reuse information.
Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat
Open the record for dataset details and reuse information.
Data from: RAD-sequencing reveals within-generation polygenic selection in response to anthropogenic organic and metal contamination in North Atlantic Eels
Open the record for dataset details and reuse information.
Data from: Disentangling selection on genetically correlated polygenic traits using whole-genome genealogies
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.