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133 results for “polyunsaturated fatty acids”
Homology modelling, molecular docking and molecular dynamics simulations of wild type and mutant human CYP2J2 with three polyunsaturated fatty acids
<p>This is the "parent" repository for the Data Note : "­Molecular dynamics simulations of the interaction of wild type and mutant human CYP2J2 with polyunsaturated fatty acids" by Abelak, Bishop-Bailey and Nobeli.</p> <p>It contains a document (<strong>Abelak_etal_Methods.pdf</strong>) describing the methods used to produce the data here and the data in all repositories supplementing it.</p> <p>It also contains a shell script (<strong>create_sim4_repeats.sh</strong>) that is typical of those used to set up the molecular dynamics simulations in the repositories supplementing this one.</p> <p>Finally, it contains the results of the homology modelling and docking simulations that formed the starting points for the molecular dynamics simulations in this study.</p> <p>Description of files in this dataset:</p> <p><strong>C2J2_min3_mod_noH.pdb</strong> : Homology model of the wild type CYP2J2 built from an alignment of templates with PDB ids: 1SUO, 2P85, 3EBS and 1Z10.</p> <p><strong>docking_wild_type_C2J2.zip</strong> : Nine docked poses of arachidonic acid docked to the homology model of the wild type CYP2J2.</p> <p>Details of how this data was produced is available in the Abelak_etal_Methods.docx document.</p>
Code and data from: Experiential legacies of early-life dietary polyunsaturated fatty acid (PUFA) content on juvenile Walleye: Potential impacts from climate change
<p>Climate-induced shifts in plankton blooms may alter fish recruitment by affecting the fatty acid composition of early-life diets and corresponding performance. Early-life nutrition may immediately affect survival but may also have a lingering influence on size and growth via experiential legacies. We explored the short- and longer-term performance consequences of different concentrations of polyunsaturated fatty acids (PUFA) for juvenile Walleye (<em>Sander vitreus</em>, Mitchill 1818). For the first 10 d of feeding, juveniles were provided <em>Artemia </em>enriched with: oleic acid (low PUFA), high docosahexaenoic acid and high eicosapentaenoic acid (high PUFA), or high PUFA and a form of vitamin E (high PUFA + E). After 10 d, all fish were fed a high-quality diet and reared for an additional 27 d. Juveniles fed either high PUFA diet were 1.15-fold larger (PUFA mean ± SD = 20.0 ± 3.3 mg; PUFA + E = 19.8 ± 3.3 mg) than those fed the low PUFA (17.3 ± 2.8 mg) diet after 10 d of feeding. After 27 days, juveniles initially fed the high PUFA diet were still 1.10-1.20-fold larger (PUFA = 407.0 ± 61.6 mg; PUFA + E = 422.7 ± 58.7 mg) than those initially fed the low PUFA diet (356.5.0 ± 39.5 mg). Our findings demonstrate that fatty acid composition of juvenile Walleye diets has immediate and lingering size effects. As changes in climate continue to alter lower trophic levels, fish management and conservation may need to consider short- and long-term effects of temporal or spatial differences in early-life diet quality.</p>
Fig. 3 in An Effectiveness Of Artemia Nauplii Enrichment With Polyunsaturated Fatty Acids Using A Supplement Easy Dha Selco
Fig. 3. Lipase (А) та α-amylase (B) activities in Artemia nauplii at the different schemes of bioencapsulation with Easy DHA Selco.
Fig. 2 in An Effectiveness Of Artemia Nauplii Enrichment With Polyunsaturated Fatty Acids Using A Supplement Easy Dha Selco
Fig. 2. Total proteolytic activity in Artemia nauplii at the different pH during bioencapsulation with Easy DHA Selco (A – pH 4.8; B – pH 7.4; C – pH 9.0).
FIGURE 4 in Effect of dietary omega-3 polyunsaturated fatty acids supplementation of Astyanax lacustris males on semen quality
FIGURE 4 | Results obtained for A. Head lateral displacement amplitude (ALH, µm) and B. Crossbeat frequency (BCF, Hz), after feeding with the inclusion of PUFAs-ô3 in the diet of Astyanax lacustris for a period of 105 days. In-0 – diet without inclusion of PUFAs-ô3; In-3 – feed with inclusion of 3% PUFAs-ô3; In-6 – feed with inclusion of 6% of PUFAs-ô3; In-9 – feed with inclusion of 9% PUFAs-ô3. Different lowercase letters indicate statistical difference between treatments for ALH and BCF (Kruskal-Wallis, p<0.05).
FIGURE 3 in Effect of dietary omega-3 polyunsaturated fatty acids supplementation of Astyanax lacustris males on semen quality
FIGURE 3 | Results obtained for A. Linearity (LIN, %), B. Straightness coefficient (STR, %) and C. Mean oscillation of the spatial trajectory (WOB, %), after feeding with the inclusion of PUFAs-ô3 in the diet of Astyanax lacustris for a period of 105 days. In-0 – diet without inclusion of PUFAs-ô3; In-3 – feed with inclusion of 3% PUFAs-ô3; In-6 – feed with inclusion of 6% of PUFAs-ô3; In-9 – feed with inclusion of 9% PUFAs-ô3. Different lowercase letters indicate statistical difference between treatments for LIN, STR and WOB (Kruskal-Wallis, p<0.05).
FIGURE 2 in Effect of dietary omega-3 polyunsaturated fatty acids supplementation of Astyanax lacustris males on semen quality
FIGURE 2 | Results obtained for A. Percentage of fast (SptzRápido), medium (SptzMedium) and slow (SptzSlow), B. Curvilinear velocity (VCL, µm/s), C. Linear velocity (VSL, µm/ s), D. Mean velocity (VAP, µm/s%) after feeding with the inclusion of PUFAs-ô3 in the diet of Astyanax lacustris for a period of 105 days. In-0 – diet without inclusion of PUFAs-ô3; In-3 – feed with inclusion of 3% PUFAs-ô3; In-6 – feed with inclusion of 6% of PUFAs-ô3; In-9 – feed with inclusion of 9% PUFAs-ô3. Different capital letters indicate statistical difference between treatments for SptzFast. Different lowercase letters indicate statistical difference between treatments for SptzMedium, SptzSlow percentage, VCL, VSL and VAP (Kruskal-Wallis, p<0.05).
FIGURE 1 in Effect of dietary omega-3 polyunsaturated fatty acids supplementation of Astyanax lacustris males on semen quality
FIGURE 1 | Results obtained for total (MOT, %) and progressive (PRG, %) sperm motility after feeding with the inclusion of PUFAs-ô3 in the diet of Astyanax lacustris for a period of 105 days. In-0 – diet without inclusion of PUFAs-ô3; In-3 – feed with inclusion of 3% PUFAs-ô3; In-6 – feed with inclusion of 6% of PUFAs-ô3; In-9 – feed with inclusion of 9% PUFAs-ô3. Different capital letters indicate statistical difference between treatments for MOT. Different lowercase letters indicate statistical difference between treatments for PRG (Kruskal-Wallis, p<0.05).
Code and data from: Experiential legacies of early-life dietary polyunsaturated fatty acid (PUFA) content on juvenile Walleye: Potential impacts from climate change
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Data From: Fit and fatty freshwater fish: Contrasting polyunsaturated fatty acid phenotypes between hybridizing stickleback lineages
<p>Long-chain polyunsaturated fatty acids are biologically important lipids that are unevenly distributed between and throughout environments. This heterogeneity can affect the evolution of metabolic processes, as populations adapt to the resource landscape that they encounter. Here, we compare fatty acid phenotypes of stickleback over two time scales of evolutionary divergence: between two lineages with different metabolic capacities for fatty acid synthesis (i.e. different copy number of the fatty acid desaturase gene; FADS2) that independently colonized European freshwaters during the Pleistocene and Holocene; and between two ecotypes within each lineage that have diverged more recently (~150 years) in different habitats (i.e. lake and stream). We measured fatty acid profiles of wild-caught and lab-reared fish for each lineage and ecotype combination after rearing lab fish on a diet deficient in omega-3 long-chain polyunsaturated fatty acids. Since these lineages hybridize in nature, we also measured profiles of lab-reared hybrids and backcrosses raised on the same deficient diet. Wild fish showed strong compositional differences in fatty acids between habitats, lineages, and sexes. Common garden fish had generally lower polyunsaturated fatty acid levels than wild fish, and females had lower omega-6:omega-3 than males. Fish from the lineage with fewer FADS2 copies also had lower levels of docosahexaenoic acid. Overall, we document divergence in fatty acid phenotypes between stickleback lineages with different histories of freshwater colonization, and between ecotypes in the early stages of adaptive population divergence.</p>
Data from: Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice
<p>Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in lupus-prone NZBWF1 mice is a preclinical model that is potentially applicable for investigating lipidome-modulating interventions. LPS can be expressed as one of two chemotypes: smooth LPS (S-LPS) and rough LPS (R-LPS) which is devoid of O-antigen polysaccharide sidechain. Since these chemotypes differentially affect TLR4-mediated immune cell responses, these differences may influence GN induction. Therefore, we initially compared the effects of subchronic i.p. injection for 5 wk with 1) <em>Salmonella</em> S-LPS, 2) <em>Salmonella</em> R-LPS, or 3) saline vehicle (VEH) (Study 1) in female NZBWF1 mice. R-LPS induced robust elevations in blood urea nitrogen, proteinuria, and hematuria that were not evident in VEH- or S-LPS-treated mice. Histopathologic examination of R-LPS-treated mice one week after final injection further revealed more robust hypertrophy, hyperplasia, thickened membranes, lymphocytic accumulation containing B and T cells, and glomerular IgG deposition consistent with GN but not in VEH- or S-LPS-treated groups. R-LPS but not S-LPS induced spleen enlargement with lymphoid hyperplasia as well as modest inflammatory cell recruitment in the liver. We next employed our optimized R-LPS model to discern the impact of two lipidome-modulating interventions, omega-3 polyunsaturated fatty acid (PUFA) supplementation and soluble epoxide hydrolase (sEH) inhibition, on GN (Study 2). Specifically, the effects of consuming the omega-3 PUFA docosahexaenoic acid (DHA) (10 g/kg diet) and/or the sEH inhibitor TPPU (22.5 mg/kg diet) on R-LPS triggering were compared. Resultant blood fatty acid profiles and epoxy fatty acid concentrations reflected the anticipated DHA- and TPPU-mediated lipidome changes. The relative rank order of R-LPS-induced GN severity among groups fed experimental diets based on proteinuria, hematuria, histopathologic scoring, and glomerular IgG deposition was: VEH/CON < R-LPS/DHA ≈ R-LPS/TPPU <<< R-LPS/ TPPU+DHA ≈ R-LPS/CON. These interventions had modest to negligible effects on R-LPS-induced splenomegaly, plasma antibody responses, liver inflammation, and inflammation-associated kidney gene expression. Collectively, our results show for the first time that absence of O-antigenic polysaccharide in R-LPS is critical to accelerated GN in lupus-prone mice. Furthermore, intervention by lipidome modulation through DHA feeding or sEH inhibition suppressed R-LPS-induced GN; however, these ameliorative effects were greatly diminished upon combining the treatments.</p>
The Effect of n-3 Polyunsaturated Fatty Acids in Patients With Psoriatic Arthritis
ClinicalTrials.gov study NCT01818804. IPD Sharing: YES. Countries: 1. Publications: 2.
Omega-3 Long Chain Polyunsaturated Fatty Acid (LCPUFA) Supplementation in Very Low Birth Weight Infants for The Prevention Retinopathy of Prematurity
ClinicalTrials.gov study NCT02486042. IPD Sharing: NO. Countries: 1. Publications: 17.
Omega Tots: A Randomized, Controlled Trial of Long-chain Polyunsaturated Fatty Acid Supplementation of Toddler Diets and Developmental Outcomes
ClinicalTrials.gov study NCT01576783. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver
ClinicalTrials.gov study NCT00323414. IPD Sharing: Not stated. Countries: 1. Publications: 2.
n-3 Polyunsaturated Fatty Acids (PUFAs) in the Prevention of Atrial Fibrillation
ClinicalTrials.gov study NCT01198275. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fish Oil-derived N-3 Polyunsaturated Fatty Acids and Extracellular Vesicles
ClinicalTrials.gov study NCT03203512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice
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Data from: Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice
Open the record for dataset details and reuse information.
Data From: Fit and fatty freshwater fish: Contrasting polyunsaturated fatty acid phenotypes between hybridizing stickleback lineages
Open the record for dataset details and reuse information.
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