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54 results for “prenatal development”
Impact of prenatal THC exposure on mouse brain development; a lifespan approach with MRI
<p>Prenatal cannabis exposure has been demonstrated to impact neurodevelopment in offspring at different ages. To date, to our knowledge, no study has longitudinally examined the effects from embryos to adulthood. Here we collected and analyzed data to explore how prenatal exposure to delta-9-tetrahydrocannabinol (5 mg/kg subcutaneous injections, gestational dat [GD] 3-10) in mice impacts trajectories of brain development with structural magnetic resonance imaging. We supplement these findings with behavioural analyses and electron microscopy as described below.</p> <p>In the first cohort (embryos) embryos were extracted on GD 17 and scanned with MRI postnatally, as described in the methods of the accompanying paper. Electron microscopy was used to investigate dark neural and glial cells, apoptotic cells, and dividing cells in the hippocampus. In the second cohort (neonates) pups were born and scanned postnatally with manganese enhanced MRI on postnatal day (PND) 3, 5, 7, and 10. Separation-induced ultrasonic vocalizations were acquired on PND 12 and pups were perfused on PND 13. EM analyses were repeated in the neonatal hippocampi. In the third cohort (adults) pups were scanned on PND 25, 35, 60, and 90. Behavioral assessments for anxiety-like behavior with open-field test and sensorimotor gating with prepulse inhibition were performed on PND 35 and 37 respectively. </p> <p>Findings showed altered prenatal body volumes and weight-trajectories, altered brain volumes (especially sustained in females until adulthood), and indications of changes to behavior, including anxiety-like phenotypes in neonates and adolescents. Evidence from electron microscopy suggests increased cell division in the embryo hippocampus. Together these data suggest a profound and sustained impact of early gestation prenatal THC exposure on brain development. For further details on the methods, approach, and results, please see the forthcoming publication.</p> <p>In this dataset you will find the following data:</p> <p>Pregnancy/dam-level outcomes can be found in maternal_outcomes.zip</p> <ul> <li><a href="../api/records/13820978/draft/files/zenodo_pregnancy_README.txt/content" target="_blank" rel="noopener noreferrer">zenodo_pregnancy_README.txt</a>: includes description of the data and fields available in each csv.</li> <li>dam_weights.csv: A spreadsheet including the information related to each dam pooled across the studies</li> <li>nest_quality.csv: A spreadsheet including the manually-rated nest quality from a pilot and the full experiment</li> <li>master_maternal_observations_old_thc.csv: A spreadsheet including data for time spent on and off nest extracted automatically and manually from Ethovision</li> </ul> <p>Embryo outcomes:</p> <ul> <li>zenodo_embryos_README.txt: includes description of the data and fields available in each csv.</li> <li>demographics_for_analysis.csv: A spreadsheet with relevant information for each embryo sample.</li> <li>raw_embryo_mincs.zip: includes 84 embryo scans, full body</li> <li>embryo_heads.zip: includes 57 embryo scans that all passed qc, head only niftis </li> <li>squish_qc.csv: QC of whether the embryos were squished or not</li> <li>em_embryo_hc_mm2csv.csv: cells per mm^2 from electron microscopy</li> </ul> <p>Neonate outcomes:</p> <ul> <li>zenodo_neonates_README.txt: includes description of data and fields available in each csv</li> <li>demographics.csv: A spreadsheet with the demographic information for each pup and timepoint in the study</li> <li>raw_neonate_niftis.zip: 172 scans from neonates in nifti format</li> <li>agreement_qc.csv: quality control file with assessments of raw images</li> <li>milestones_999_as_NA.csv: Record of which milestones were tested and whether they were obtained</li> <li>master_usv.csv: Spreadsheet including data for ultrasonic vocalizations from all tested pups</li> <li>neo_cell_counts_mm2.csv: cells per mm^2 from electron microscopy for the neonates</li> </ul> <p>Adult outcomes: </p> <ul> <li>zenodo_adult_README.txt: includes description of the data and fields available in each csv.</li> <li>demographics.csv: A spreadsheet with the demographic information for each mouse and timepoint in the study</li> <li>adult_raw_niftis.zip: The raw data (before preprocessing) in nifti format</li> <li>master_qc.csv: Quality control assessment of the raw images</li> <li>master_oft.csv: Values for open field test extracted from Ethovision</li> <li>avg_trials_ppi.csv: Data from prepulse inhibition trials, average startle of 100 ms following pulse</li> <li>max_trials_ppi.csv Dat afrom prepulse inhibition trials, maximum startle of 100 ms following pulse</li> </ul>
Prenatal skeletogenesis partially recovers from absent skeletal muscle as development progresses
<p>Raw data (measurements made) for paper entitled "Prenatal skeletogenesis partially recovers from absent skeletal muscle as development progresses"</p>
Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality
<p>Supplementary Figures</p> <p><strong>Figure S1</strong>. Picro-sirius red stained sections of lung at E18.5.</p> <p><strong>Figure S2</strong>. Cell apoptosis assay by TUNEL staining. A. Immunofluorescent TUNEL staining of E18.5 lungs. Scale bar: 66.2μm. B. Quantitative analysis by counting of multiple sections from 3 independent samples per group. NS= not significant by student’s t- test.</p> <p><strong>Table S1</strong>. Summary of RNA-Seq mapping results. The raw reads were mapped to the Mus Musculus genome (GRCm38) using TopHat2.</p> <p><strong>Table S2</strong>. List of DEG (Differentially Expressed Gene) from RNA-Seq analysis results. Differentail expression analysis was carried out using DESeq2.</p> <p><strong>Table S3</strong>. List of DEGs annotated under Gene Ontology (GO) terms cell cycle and immune system process.</p> <p><strong>Table S4</strong>. List of DEGs annotated under KEGG Pathway oxidative phosphorylation and hematopoietic cell lineage pathways. </p>
The prenatal hypoxic pathology associated with maternal stress predisposes to dysregulated expression of the chrna7 gene and the subsequent development of nicotine addiction in adult offspring (Supplementary)
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Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease
ClinicalTrials.gov study NCT06160037. IPD Sharing: YES. Countries: 1. Publications: 87.
Neurobehavioral Development in Toddlers and Preschoolers in Relation to Prenatal Exposure of Mild Analgesics (NeuroToP - a COPANA Follow up)
ClinicalTrials.gov study NCT07316387. IPD Sharing: Not stated. Countries: 1. Publications: 30.
Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development
ClinicalTrials.gov study NCT01020669. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
ClinicalTrials.gov study NCT02109770. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
ClinicalTrials.gov study NCT06147414. IPD Sharing: NO. Countries: 1. Publications: 1.
Prenatal DHA and Neurofunctional Development
ClinicalTrials.gov study NCT02709239. IPD Sharing: NO. Countries: 1. Publications: 2.
Development of a Nationally Scalable Model of Group Prenatal Care to Improve Birth Outcomes: "Expect With Me"
ClinicalTrials.gov study NCT02169024. IPD Sharing: NO. Countries: 1. Publications: 3.
Effects of Prenatal DHA Supplements on Infant Development
ClinicalTrials.gov study NCT00646360. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Prenatal Test
ClinicalTrials.gov study NCT06385366. IPD Sharing: YES. Countries: 1. Publications: 19.
PERINE : Effect of Prenatal Exposure to Neurotoxicants on the Developing Brain : an MRI Study
ClinicalTrials.gov study NCT02125110. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
ClinicalTrials.gov study NCT04595214. IPD Sharing: UNDECIDED. Countries: 6. Publications: 1.
The prenatal hypoxic pathology associated with maternal stress predisposes to dysregulated expression of the chrna7 gene and the subsequent development of nicotine addiction in adult offspring (Supplementary)
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Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood
ClinicalTrials.gov study NCT04285814. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Age-related prenatal maternal effects and postnatal breeding experience have different influences on nestling development in an altricial passerine
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Data from: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
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Single-nucleus transcriptomics atlas of middle and late prenatal human cortical development
GEO Series GSE217511. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.