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37 results for “presynaptic”
BRAIN Journal-Evolving Spiking Neural Networks for Control of Artificial Creatures-Figure 2. Example of different axonal conduction delay between presynaptic neuron A0 and postsynaptic neuron A1 and A2
<p>Different axonal conduction delays between every two neurons are applied as follows:<br> For instance, consider presynaptic neuron A0 and postsynaptic neurons A1 and A2 in Figure 2. If neuron A0 fires spike S0 in t = 9 and S1 in t = 11 and with a time step equal to 0.5 ms, S0 arrives to A1 in t = 13 and to A2 in t = 14 where S1 arrives to A1 in t = 15 and to A2 in t = 16. This is implemented using counters assigned to each spike which increases with each time step in the time window. If counters arrive to axonal delay values, the effect of spikes from presynaptic neuron applies to the post synaptic neurons.</p>
BRAIN Journal-Evolving Spiking Neural Networks for Control of Artificial Creatures-Figure 4: Pseudo code for applying different axonal conduction delay between presynaptic neurons and postsynaptic neurons
<p>In each time step, axonal conduction delays between presynaptic neurons and postsynaptic neurons are examined whether they are equal to the elements of array I_S, to apply the respective spikes.<br> The pseudo code for applying different axonal conduction delay between presynaptic neurons and postsynaptic neurons are shown in Figure 4.</p>
Data from: Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
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Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
<p>The MFB_cLTP_Data zip folder contains the data from the publication by Orlando M, Dvorzhak A, Bruentgens F, Maglione M, Rost BR, Sigrist SJ, Breustedt J, and Schmitz D. "Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber <em>boutons" </em>that is under revision at PLOS Biology. </p> <p>Each file corresponds to a figure in the paper. The folder contains data from two photon live glutamate imaging, STED microscopy, electron microscopy of murine hippocampal mossy fiber boutons and autaptic neuron electrophysiology. We compared boutons in control conditions (CTRL) with boutons at wich chemical potentiation was induced by the application of 50 µM Forskolin for 15 minutes (FSK).</p>
Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling
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Data from: Selective presynaptic inhibition of leg proprioception in behaving <em>Drosophila</em>
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Data from: Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network
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Source data for: Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine
<p><span>In the rodent olfactory bulb the smooth dendrites of the principal glutamatergic mitral cells (MCs) form reciprocal dendrodendritic synapses with large spines on GABAergic granule cells (GC), where unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na<sup>+</sup>-channels (Na<sub>v</sub>s), i.e. a spine spike. Can such single MC input evoke reciprocal release? We find that unitary-like activation via two-photon uncaging of glutamate causes GC spines to release GABA both synchronously and asynchronously onto MC dendrites. This release indeed requires activation of Na<sub>v</sub>s and high-voltage-activated Ca<sup>2+</sup>-channels (HVACCs), but also of NMDA receptors (NMDAR). Simulations show temporally overlapping HVACC- and NMDAR-mediated Ca<sup>2+</sup>-currents during the spine spike, and ultrastructural data prove NMDAR presence within the GABAergic presynapse. The cooperative action of presynaptic NMDARs allows to implement synapse-specific, activity-dependent lateral inhibition and thus could provide an efficient solution to combinatorial percept synthesis in a sensory system with many receptor channels. </span></p>
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
ClinicalTrials.gov study NCT06875765. IPD Sharing: NO. Countries: 1. Publications: 2.
Source data for: Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine
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Data from: Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome
During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has recently been implicated in a dominantly inherited congenital myasthenic syndrome associated with a non-progressive motor neuropathy. In one family, a proline residue within the C2B Ca2+-binding pocket of synaptotagmin is replaced by a leucine. The functional significance of this residue has not been investigated previously. Here we show that in silico modeling predicts disruption of the C2B Ca2+-binding pocket, and we examine the in vivo effects of the homologous mutation in Drosophila. When expressed in the absence of native synaptotagmin, this mutation is lethal, demonstrating for the first time that this residue plays a critical role in synaptotagmin function. To achieve expression similar to human patients, the mutation is expressed in flies carrying one copy of the wild type synaptotagmin gene. We now show that Drosophila carrying this mutation developed neurological and behavioral manifestations similar to those of human patients and provide insight into the mechanisms underlying these deficits. Our Drosophila studies support a role for this synaptotagmin point mutation in disease etiology.
Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery.
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Presynaptic site
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Expression of enteric nerve fibers and the presynaptic protein synaptophysin1 in the mucosa of the DSS-induced colitis mouse colon
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Supplementary figure 1. Expression of enteric nerve fibers and the presynaptic protein synaptophysin1 in the mucosa of the DSS-induced colitis mouse colon
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Data from: Cyfip1 regulates presynaptic activity during development
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Data from: Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome
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Presynaptic dysfunction in CASK-related neurodevelopmental disorders
GEO Series GSE140572. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
GEO Series GSE208738. Mus musculus. 4 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.