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14,544 results for “prevention”
Impacts of Hemlock Woolly Adelgid After Preventative Treatment in Lincoln MA 2015-2018
In 2007 the town of Lincoln, MA treated the hemlock stand at the Codman estate with root injections of imidacloprid to suppress the invasive insect Hemlock Wooly Adelgid (HWA). This hemlock grove is unique for this area of Massachusetts and dominated by eastern hemlock of approximately 2 feet in diameter with many trees reaching heights of over 120 feet. The treatment goal was to conserve the trees and the stand’s cathedral-like characteristics. To accomplish this goal, every big canopy tree was treated.
Pawpaws prevent predictability: A locally-dominant tree alters understory beta-diversity and community assembly
<p>Data used in "Pawpaws Prevent Predictability: A locally-dominant tree alters understory beta-diversity and community assembly" (Wassel and Myers) accepted for publication in Ecosphere.<br><br><strong>Metadata for Zenodo.pdf </strong>contains more information on the following data files including descriptions of the columns. </p> <p>The file <strong>understory_abundance_data2021.csv</strong> contains all species abundances in 1x1m plots. This data was used for analyses in publication. Each row is a plot, each column is a speceis or plot descriptor, values for columns 5 and higher are species abundances. Data was collected July-August 2021 by Anna Wassel in Missouri, USA. </p> <p>The file <strong>understory_species_list2021.csv </strong>contains a list of the species codes used in the first file with their scientific names and their status as herbs or woody. This was used to filter out herbaceous species from the data set for herbaceous-only analyses. </p> <p> </p>
CFMDG: a Coastal Flood Modelling Dataset in Gâvres (France) to support risk prevention and metamodels development
<p>Along most of the coastal areas, detailed coastal flood observations (e.g. inland water depths) are scarce, and when they are available, this for a limited number of events. Given recent scientific advances, <strong>coastal flooding</strong> events can be properly modelled, even in complex environments and under the action of wave overtopping, and thus provide detailed information. However, such models are computationally expensive, which prevents their use for instance for forecasting and warning. At the same time, metamodelling techniques have been explored for coastal hydrodynamics and have shown promising results. Metamodels are functions that aim to reproduce the behaviour of a “true” model (e.g., a numerical hydrodynamic model) for given input variables (for instance, offshore conditions). Within the RISCOPE research project (<a href="http://perso.math.univ-toulouse.fr/riscope">https://perso.math.univ-toulouse.fr/riscope</a>/) aiming at exploring to which extent such metamodelling techniques may allow to forecast coastal floods with a good accuracy, a <strong>simulated flood database</strong> has been built for the site of Gâvres (France), characterised by a significant effect of wave overtopping processes.</p> <p>The <strong>CFMDG dataset </strong>compiles a set of post-processed coastal flood simulations on the site of Gâvres. The dataset includes 250 scenarios. Each scenarios is defined by 6h time series centered on high tide, with one time series per forcing variables. The forcing variables (called X) are: local relative mean sea-level, tide, atmospheric storm surge, the offshore wave characteristics and the offshore wind. These scenarios combine past real (flood and no flood) events in the 1900-2021 time span with extreme statistics based events, and some complementary fictive events. The post-processed outputs (called Y) includes, for each scenario, the maximal flooded area (m²) and the maximal water depth (m) in each of the 64 618 inland model grid points.</p> <p>The modelling chain that allowed building this dataset relies on the joint use of a spectral wave model (WW3) to propagate the waves to the coast, and a non-hydrostatic wave-flow model (SWASH) to simulate the nearshore hydrodynamics and the flooding. The spatial and temporal resolution of the SWASH configuration validated on the Gâvres site are respectively 3 m and more than 10Hz. All the results are obtained for a Digital Elevation Model corresponding to the 2018 configuration of the site. </p> <p>Such type of dataset is of use for local knowledge, risk prevention, metamodel testing/training, and local coastal flood forecast. </p> <p>Part of this dataset has already been used in (<a href="http://www.mdpi.com/2077-1312/9/11/1191">Idier et al., 2021</a>; <a href="http://www.sciencedirect.com/science/article/pii/S0951832021006293?via%3Dihub">López-Lopera et al., 2021</a>; <a href="https://hal.science/hal-02536624">Betancourt et al., 2022</a>), to develop metamodels and set up a coastal flood forecast and early warning prototype.</p> <p>We hope and expect that making this dataset accessible will trigger further developments/investigations for improving risk knowledge on the considered site as well as methodological developments on machine-learning/metamodel-based techniques to support flood forecast.</p> <p>The table below summarizes the variables contained in the dataset, for each scenario.</p> <table> <tbody> <tr> <td> <p><strong>Variable name</strong></p> </td> <td> <p><strong>Description and unit </strong></p> </td> <td> <p><strong>Comment</strong></p> </td> </tr> <tr> <td> <p>Scenario n°</p> </td> <td> <p>Number of the scenario.</p> </td> <td> <p> </p> </td> </tr> <tr> <td> <p><strong>INPUTS (X)</strong></p> </td> </tr> <tr> <td> <p>NM</p> </td> <td> <p>Relative mean sea level, referenced to the French vertical datum (m, IGN69)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>T</p> </td> <td> <p>Tidal water level (m), referenced to the relative mean sea level</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>S</p> </td> <td> <p>Atmospheric storm surge (m)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>Hs</p> </td> <td> <p>Significant wave height (m)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>Tp</p> </td> <td> <p>Wave peak period (s)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>Dp</p> </td> <td> <p>Wave peak direction (° in nautical convention)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>U</p> </td> <td> <p>Wind speed (m/s)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>DU</p> </td> <td> <p>Wind direction (° in nautical convention)</p> </td> <td> <p>Time series over 6h</p> </td> </tr> <tr> <td> <p>t</p> </td> <td> <p>Relative time centered on the high tide of each event (min)</p> </td> <td> <p>Not Concerned</p> </td> </tr> <tr> <td> <p>High Tide date</p> </td> <td> <p>UTC date for scenarios corresponding to past real events</p> </td> <td> <p>Not Concerned</p> </td> </tr> <tr> <td> <p><strong>OUTPUTS (Y)</strong></p> </td> </tr> <tr> <td> <p>Smax</p> </td> <td> <p>Maximum flooded area during the event (m²)</p> </td> <td> <p>Post-processed scalar output</p> </td> </tr> <tr> <td> <p>Hmax</p> </td> <td> <p>Maximum water depth reached during the event (m), provided for each inland location</p> </td> <td> <p>Post-processed functional (map) output</p> </td> </tr> <tr> <td> <p>longitude</p> </td> <td> <p>Longitude (°, WGS84)</p> </td> <td> <p>For each inland location point</p> </td> </tr> <tr> <td> <p>latitude</p> </td> <td> <p>Latitude (°, WGS84)</p> </td> <td> <p>For each inland location point</p> </td> </tr> <tr> <td> <p>XL93</p> </td> <td> <p>Longitude (m, Lambert 93)</p> </td> <td> <p>For each inland location point</p> </td> </tr> <tr> <td> <p>YL93</p> </td> <td> <p>Latitude (m, Lambert 93)</p> </td> <td> <p>For each inland location point</p> </td> </tr> </tbody> </table> <p> </p> <p> </p> <p><br> </p>
LMU Fast Decompression Experiment Data for "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows"
<p><strong>Background</strong></p> <p>This data is camera images and nozzle pressure gauge voltage traces from rapid decompression shots at the LMU shock tube facility.</p> <p>This data is discussed in the "Materials and Methods" section of the paper "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows".</p> <p>Electric sparks and explosive flows have long been associated with each other. Flowing dust particles originate charge through contact and separate based on inertia, resulting in strong electric fields supporting sparks. These sparks can cause explosions in dusty environments, especially those rich in carbon, such as coal mines and grain elevators. Recent observations of explosive events in nature and decompression experiments indicate that supersonic flows of explosions may alter the electrical discharge process. Shocks may suppress parts of the hierarchy of the discharge phenomena, such as leaders. In our decompression experiments, a shock tube ejects a flow of gas and particles into an expansion chamber. We imaged an illuminated plume from the decompression of a mixture of argon and <100 mg of diamond particles and observe sparks occurring below the sharp boundary of a condensation cloud. We also performed hydrodynamics simulations of the decompression event that provide insight into the conditions supporting the observed behavior. Simulation results agree closely with the experimentally observed Mach disk shock shape and height. This represents direct evidence that the sparks are sculpted by the outflow. The spatial and temporal scale of the sparks transmit an impression of the shock tube flow, a connection that could enable novel instrumentation to diagnose currently inaccessible supersonic granular phenomena.</p> <p><strong>Accessing Data</strong></p> <p>The prefixes of the filenames correspond to the shot dates and times listed in table S1 of the paper. </p> <p>The "_camera.zip" files contains tiff images of the camera frames. The ".ixc" file in each zip lists camera settings in plain text.</p> <p>The ".dat" file contains the voltage measurement of the nozzle pressure gauge. Row 1 is the header, row 2 is the time in seconds, and row 3 is the voltage of the pressure gauge in Volts. The peak pressure in the header can be used to relate the voltage to pressure.</p>
Compressible Hydrodynamics Simulation Data for "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows"
<p><strong>Background</strong></p> <p>This data is a 2D cross-section from a 3D compressible hydrodynamics simulation (Hyburn / AMRex code) of a rapid decompression / shock tube experiment at Special Technologies Laboratory. The simulated shot is a pure argon gas decompression from 1000Psi to atmosphere. </p> <p>This data is used in figures 3 and 5 of the paper "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows".</p> <p>Electric sparks and explosive flows have long been associated with each other. Flowing dust particles originate charge through contact and separate based on inertia, resulting in strong electric fields supporting sparks. These sparks can cause explosions in dusty environments, especially those rich in carbon, such as coal mines and grain elevators. Recent observations of explosive events in nature and decompression experiments indicate that supersonic flows of explosions may alter the electrical discharge process. Shocks may suppress parts of the hierarchy of the discharge phenomena, such as leaders. In our decompression experiments, a shock tube ejects a flow of gas and particles into an expansion chamber. We imaged an illuminated plume from the decompression of a mixture of argon and <100 mg of diamond particles and observe sparks occurring below the sharp boundary of a condensation cloud. We also performed hydrodynamics simulations of the decompression event that provide insight into the conditions supporting the observed behavior. Simulation results agree closely with the experimentally observed Mach disk shock shape and height. This represents direct evidence that the sparks are sculpted by the outflow. The spatial and temporal scale of the sparks transmit an impression of the shock tube flow, a connection that could enable novel instrumentation to diagnose currently inaccessible supersonic granular phenomena.</p> <p><strong>Accessing Data</strong></p> <p>The data is saved as python numpy zipped archives numbered by the timestep in the simulation. Files starting with 'tube' contain data from inside the shock tube. Files starting with 'near_vent' contain data from the expansion chamber above the nozzle. All units are in SI.</p> <p>Each .npz file is an array file generated with python numpy.savez(). It can be opened with:</p> <p><em>import numpy as np</em></p> <p><em>data = np.load('<name>.npz')</em></p> <p>The data is an python dictionary. The dictionary keys can be displayed with:</p> <p><em>print(data.files)</em></p> <p>The numpy arrays can be accessed by keyname:</p> <p><em>print(data['keyname'])</em></p> <p>The key names correspond to physical quantities (density, temperature, etc.). All particle quantities are 0 as the simulation did not include particles.</p>
Figures and videos for: Patterned invagination prevents mechanical instability during gastrulation
<p>This repository contains the high-resolution figures and videos for the paper:</p> <p>Vellutini, B. C., Cuenca, M. B., Krishna, A., Szałapak, A., Modes, C. D. & Tomancak, P. Patterned invagination prevents mechanical instability during gastrulation. <em>Nature</em> (2025). doi:<a href="https://10.0.4.14/s41586-025-09480-3">10.1038/s41586-025-09480-3</a></p> <p>Please refer to the main repository for more information: <a href="https://doi.org/10.5281/zenodo.7781947">https://doi.org/10.5281/zenodo.7781947</a></p>
Results: Predicted cooling effect, deaths prevented and associated economic value from public green spaces in Paris V2
<p>This dataset represents results predicting the cooling effect, deaths prevented and associated economic value for public green spaces in Paris for 40 hot days above the minimum mortality threshold in 2019. </p> <p>This is version 2. The value of a statistical life (VSL) has been corrcted and all values adjusted. </p> <p>The data format is a shapefile with coordinate reference system RGF93 v1 / Lambert-93 (EPSG:2154).</p> <p>Please see the Variable_name csv file for description of the variable names. </p> <p>The (non-reproducible) code is available at https://github.com/j-k-garrett/REGREEN_Paris_heat</p> <p>These results are from the submitted (September 2025) paper entitled:</p> <p><strong><span>Nature-Based Solutions for Urban Heat: Health and Economic Value of Paris’s Public Green Spaces</span></strong></p> <p>Authored by:</p> <p>Joanne K. Garrett<sup>1</sup>, David Neil Bird<sup>2</sup>, Timothy J. Taylor<sup>1</sup>, Elizabeth McCarthy<sup>3</sup>, David H. Fletcher<sup>4</sup>, Benedict W. Wheeler<sup>1</sup>, Marianne Zandersen<sup>5</sup>, Laurence Jones<sup>3</sup></p> <p><sup>1</sup>European Centre for Environment and Human Health, University of Exeter, Penryn, Cornwall, UK</p> <p><sup>2 </sup>Institute for Climate, Energy and Society, JOANNEUM RESEARCH, Graz, Austria</p> <p><sup>3</sup> Department of Environmental Studies, Schiller Institute for Integrated Science and Society, Boston College, USA</p> <p><sup>4</sup> UK Centre for Ecology & Hydrology, Environment Centre Wales, Bangor, Gwynedd, Wales, UK</p> <p><sup>5 </sup>Department of Environmental Science, iClimate Interdisciplinary Centre for Climate Change, Aarhus University, Denmark</p> <p> </p>
Supplementary input data for accounting for component condition and preventive retirement in power system reliability of supply analyses
<div> <div>This data set contains supplementary data used for case studies on accounting for transformer condition in reliability of supply analyses in the following manuscripts: <br>1) H. Toftaker, J. Foros, I. B. Sperstad, "Accounting for component condition and preventive retirement in power system reliability of supply analyses", IET Generation, Transmission & Distribution, vol. 5, no. 1, 2023, DOI: 10.1049/gtd2.12761. <br>2) I. Bjerkebæk, I. B. Sperstad, H. Toftaker, G. Kjølle, "Simulating the Long Term Effect of Asset Management Strategies on Reliability of Supply", pre-print submitted for peer review, 2024. DOI: 10.36227/techrxiv.172107759.95745501/v1.</div> <div> See README.md for details.</div> </div>
Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis
<p>The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients.</p> <p>Abstract</p> <p>Objectives</p> <p>Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension.</p> <p>Materials</p> <p>Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat.</p> <p>Methods</p> <p>IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro.</p> <p>Results</p> <p>Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p<.0015 vs. Ctrl and p>0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p>.99), while Zofenopril also abrogated IH (0.1623±0.07, p<.008 vs. Ctrl and p>0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments.</p> <p>Conclusion</p> <p>Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.</p>
Ionization rate simulation data for "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows"
<p><strong>Background</strong></p> <p>This is a set of 3d data containing ionization rates computed from Hyburn hydrodynamic simulations contained in a Matlab .mat file, along with a plot in both .png and Matlab .fig format, and a Matlab script for plotting.</p> <p>This data is used in figure 5 of the paper "Standing Shock Prevents Propagation of Sparks in Supersonic Explosive Flows".</p> <p>Electric sparks and explosive flows have long been associated with each other. Flowing dust particles originate charge through contact and separate based on inertia, resulting in strong electric fields supporting sparks. These sparks can cause explosions in dusty environments, especially those rich in carbon, such as coal mines and grain elevators. Recent observations of explosive events in nature and decompression experiments indicate that supersonic flows of explosions may alter the electrical discharge process. Shocks may suppress parts of the hierarchy of the discharge phenomena, such as leaders. In our decompression experiments, a shock tube ejects a flow of gas and particles into an expansion chamber. We imaged an illuminated plume from the decompression of a mixture of argon and <100 mg of diamond particles and observe sparks occurring below the sharp boundary of a condensation cloud. We also performed hydrodynamics simulations of the decompression event that provide insight into the conditions supporting the observed behavior. Simulation results agree closely with the experimentally observed Mach disk shock shape and height. This represents direct evidence that the sparks are sculpted by the outflow. The spatial and temporal scale of the sparks transmit an impression of the shock tube flow, a connection that could enable novel instrumentation to diagnose currently inaccessible supersonic granular phenomena.</p> <p><strong>Accessing Data</strong></p> <p>The .mat file can be opened in Matlab to examine data. The 3d arrays contained therein can be viewed in various ways, including using the enclosed script with syntax like plot_isosurfaces(xg,yg,zg,density,max(density(:)),pressure,max(pressure(:))) to produce the included isosurface plot.</p> <p>The data arrays contained are:</p> <p>e: electric field magnitude</p> <p>alpha: ionization rate lengths: ionization lengths (equal to 1/alpha)</p> <p>eOverN: electric field divided by gas number density</p> <p>alphaOverN: ionization rate divided by gas number</p> <p>density density: gas mass density</p> <p>pressure: gas pressure</p> <p>x,y,z: spatial coordinates</p> <p>xg,yg,zg: spatial coordinates in 3d meshgrid format, for Matlab plotting</p> <p>The electric field e was artificially generated from velocities in Hyburn output; alpha was computed from BOLSIG+ with Hyburn input; density and pressure data were from Hyburn.</p> <p> </p>
Acquired data necessary to perform the control algorithm introduced in the scientific paper: "Multilevel control of an anthropomorphic prosthetic hand for grasp and slip prevention" (Advances in Mechanical Engineering, 2016, vol. 8, pp. 1-13)
<p>Acquired data necessary to perform the control algorithm introduced in this paper.</p> <p>a) Figure 6: Calibration data for the three FSRs placed on the prosthetic hand and covered with silicon caps.<br> b) Figure 9: Data for the cost during the learning of two grasping tasks of an egg: bi-digital grasp and tri-digital grasp.<br> c) Figure 10 and Figure 11: Data for the experimental results with the plastic cup and with the highlighter shown in the paper.<br> </p> <p> </p>
Repository for: Patterned invagination prevents mechanical instability during gastrulation
<p>This is the repository for the paper:</p> <p>Vellutini, B. C., Cuenca, M. B., Krishna, A., Szałapak, A., Modes, C. D. & Tomancak, P. Patterned invagination prevents mechanical instability during gastrulation. <em>Nature</em> (2025). doi:<a href="https://10.1038/s41586-025-09480-3">10.1038/s41586-025-09480-3</a></p> <p>Here are all the associated repositories:</p> <ul> <li><strong>Main repository (code and data):</strong> <a href="https://doi.org/10.5281/zenodo.7781947">https://doi.org/10.5281/zenodo.7781947</a></li> <li><strong>Model and simulations (code and data):</strong> <a href="https://doi.org/10.5281/zenodo.7784906">https://doi.org/10.5281/zenodo.7784906</a></li> <li><strong>Lightsheet and in situ experiments (imaging data):</strong> <a href="https://doi.org/10.5281/zenodo.15876638">https://doi.org/10.5281/zenodo.15876638</a></li> <li><strong>Laser perturbation experiments (imaging data):</strong> <a href="https://doi.org/10.5281/zenodo.15876646">https://doi.org/10.5281/zenodo.15876646</a></li> <li><strong>Figures and videos (media files):</strong> <a href="https://doi.org/10.5281/zenodo.7781916">https://doi.org/10.5281/zenodo.7781916</a></li> </ul> <p>The main repository is maintained at <a href="https://github.com/bruvellu/cephalic-furrow">https://github.com/bruvellu/cephalic-furrow</a>.</p>
Awareness campaign video for local communities: Understanding and Preventing Rabies in the Menabe Region, Madagascar
<p>Cette courte vidéo est un outil utilisé pour la sensibilisation contre la rage. </p><p>Elle a été produite dans le cadre d'une recherche opération dans le sud ouest de Madagascar dans la région Menabe.</p><p>Elle présente en langue Malagasy, sous-titrée en Français:</p><p>- Ce qu'est la rage: la rage est une maladie due par une morsure d'un animal enragé ou le léchage de la plaie d'une personne par un animal enragé. Le chien est responsable de la rage dans près de 9 cas sur 10.</p><p>- actions à entreprendre à si une personne a été mordue par un chien</p><p>- les gestes à effectuer si une personne a été mordue par un chien</p><p>- elle insiste sur le fait que chez l'homme, la rage est traitable à 100% avant l'apparition du premier symptôme.</p><p>La vidéo est aussi disponible sur Youtube : </p><p><i>https://www.youtube.com/watch?v=RBK3Uywxszo&ab_channel=DaoudaKassi%C3%A9</i></p>
Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid - preventive therapies for people living with HIV.
<p>This is the minimal data set underlying the findings of our systematic review and metasummary:</p> <p>We uploaded the following data extracted from the studies included in our review:</p> <p>- Systematic Review protocol, also published in PROSPERO (CRD42019137778).</p> <p>- detailed description of studies included in our review.</p> <p>- barriers identified in the review (metasummary).</p> <p>- facilitators identified in the review.</p>
Modeling robust COVID-19 intensive care unit occupancy thresholds for imposing mitigation to prevent exceeding capacities
<p>Simulation output files for 'Modeling robust COVID-19 intensive care unit occupancy thresholds for imposing mitigation to prevent exceeding capacities'.</p> <p>Simulating COVID-19 transmission and hospital burden to assess at which intensive care unit (ICU) occupancies mitigation, that reduces transmission, needs to be triggered to avoid exceeding ICU capacity limits, using the city of Chicago, Illinois as an example.</p> <p>Manuscript is under review for scientific publication, (see <a href="https://www.medrxiv.org/content/10.1101/2021.06.27.21259530v1">preprint on medRxiv</a>) and scripts are available from the GitHub repository at https://github.com/numalariamodeling/ICUtrigger_covid_chicago_paper_2021. </p> <p>Simulation output files uploaded per scenario including projected COVIID-19 transmission and burden trajectories for Chicago city for March 2020 to May 2021 per day.</p> <p>Simulation scenarios:</p> <p><reopening % above ICU capacity>_<delay after reaching ICU threshold>_<%mitigation>_<common simulation name> i.e. `50perc_1daysdelay_pr6_triggeredrollback_reopen`</p> <ul> <li>`emodl` file <ul> <li>required file for COVID-19 transmission model in the <a href="https://docs.idmod.org/projects/cms/en/latest/index.html">Compartmental Modeling Software</a> (see <a href="https://github.com/numalariamodeling/ICUtrigger_covid_chicago_paper_2021">GitHub repository</a> for details)</li> </ul> </li> <li>sampled_parameters.csv <ul> <li>simulation input and scenario parameters, (nrow=4400, 400 unique parameter combinations * 11 scenario values)</li> </ul> </li> <li>rt_trajectoriescovidregion_11.csv <ul> <li>estimated reproductive numbers per trajectory for complete timeline per day</li> </ul> </li> <li>trajectoriesDat_region_11_traces.csv <ul> <li>filtered to include top 100 trajectories fitted to ICU data</li> </ul> </li> <li>trajectoriesDat_region_trimfut.csv <ul> <li>truncated to only include projections after September 1st 2020</li> </ul> </li> </ul> <p>The folder `mainfigures_csvs.zip` includes processed simulation output data for the publication figures.</p>
A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection
<p>Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related infections. Niclosamide (NIC), originally an antiparasitic drug, was incorporated into the polymeric matrix of thermoplastic polyurethane (TPU) via solvent casting, and catheters were fabricated using hot-melt extrusion technology. The mechanical and physicochemical properties of TPU polymers loaded with NIC were studied. NIC was released in a sustained manner from the catheters and exhibited <em>in vitro</em> antibacterial activity against <em>Staphylococcus aureus</em> and <em>Staphylococcus epidermidis</em>. Moreover, the antibacterial efficacy of NIC-loaded catheters was validated in an <em>in vivo</em> biomaterial-associated infection mouse model using a methicillin-susceptible and methicillin-resistant strain of <em>S. aureus. </em>The released NIC from the produced catheters reduced bacterial colonization of the catheter as well as of the surrounding tissue. In summary, the NIC-releasing hot-melt extruded catheters prevented implant colonization and reduced the bacterial colonization of peri-catheter tissue by methicillin sensitive as well as resistant <em>S. aureus</em> in a biomaterial-associated infection mouse model and has good prospects for preclinical development.</p>
Young people's media use and adherence to preventive measures in the "infodemic": Is it masked by political ideology?
<p>Data to replicate the publication "Young people's media use and adherence to preventive measures in the “infodemic”: Is it masked by political ideology?". This publication examines the role of political ideology and political extremism for COVID-19 information seeking and preventive behaviour with data of the COVIDisc project. COVIDisc investigates how young people aged 15 to 34 years perceive the discussion in the Coronavirus Pandemic, which messages reach them, what media they use to inform themselves and how they experience the situation. en</p>
Monitoring feedback to authors on the quality of trials evaluating interventions aimed at preventing and treating COVID-19
<p>We aimed to assess transparency of reporting and risk of bias of randomized trials evaluating interventions aimed at preventing and treating COVID-19.</p> <p>This review is part of a larger project: the COVID-NMA project (Boutron 2020a). The COVID-NMA project aims to provide decision-makers with a complete, high-quality and up-to-date synthesis of evidence on interventions for the prevention and treatment of COVID 19. For this purpose, we perform a living mapping of all registered randomized controlled trials and a living evidence synthesis of data from RCTs. We developed a master protocol on the effect of all interventions for the prevention and treatment of COVID-19 (first published on April 8, 2020; an update on May 11, 2020, June 17, 2020, and September 8, 2020) (Boutron 2020b). We set-up a platform (<a href="https://covid-nma.com/">https://covid-nma.com</a>) where all our results are made available and updated weekly.</p>
Research data for: Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials
<p>Raw data for the publication: Preventing the coffee-ring effect and aggregate sedimentation by in situ gelation of monodisperse materials</p>
Data and code: A Comparison of Contemporary versus Older Studies of Aspirin for Primary Prevention
<p>Data (comma-separated values format) and analytical code (Stata format) relating to: Moriarty F, Ebell MH. A Comparison of Contemporary versus Older Studies of Aspirin for Primary Prevention. 2019 (under review). Available on medRxiv at https://doi.org/10.1101/19004267</p> <p><em><strong>Abstract</strong></em></p> <p><strong>Purpose</strong>: This study compares the benefits and harms of aspirin for primary prevention before and after widespread use of statins and colorectal cancer screening.</p> <p><strong>Methods: </strong>We compared studies of aspirin for primary prevention that recruited patients from 2005 onward with previous individual patient meta-analyses that recruited patients from 1978 to 2002. Data for contemporary studies were synthesized using random-effects models. We report vascular (major adverse cardiovascular events [MACE], myocardial infarction [MI], stroke), bleeding, cancer, and mortality outcomes.</p> <p><strong>Results</strong>: The IPD analyses of older studies included 95,456 patients for CV prevention and 25,270 for cancer mortality, while the four newer studies had 61,604 patients. Relative risks for vascular outcomes for older vs newer studies follow: MACE: 0.89 (95% CI 0.83-0.95) vs 0.93 (0.86-0.99); fatal hemorrhagic stroke: 1.73 (1.11-2.72) vs 1.06 (0.66-1.70); any ischemic stroke: 0.86 (0.74-1.00) vs 0.86 (0.75-0.98); any MI: 0.84 (0.77-0.92) vs 0.88 (0.77-1.00); and non-fatal MI: 0.79 (0.71-0.88) vs 0.94 (0.83-1.08). Cancer death was not significantly decreased in newer studies (RR 1.11, 0.92-1.34). Major hemorrhage was significantly increased for both older and newer studies (RR 1.48, 95% CI 1.25-1.76 vs 1.37, 95% CI 1.24-1.53). There was no effect in either group on all-cause mortality, cardiovascular mortality, fatal stroke, or fatal MI.</p> <p><strong>Conclusions</strong>: In the modern era characterized by widespread statin use and cancer screening, aspirin does not reduce the risk of non-fatal MI or cancer death. There are no mortality benefits and a significant risk of major hemorrhage. Aspirin should no longer be recommended for primary prevention.</p> <p> </p> <p>Version 1.1 - Updated Stata code to correct name of .csv data file for import.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.