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Dataset results
44 results for “primary progressive aphasia”
TMS for the Treatment of Primary Progressive Aphasia
ClinicalTrials.gov study NCT04188067. IPD Sharing: NO. Countries: 1. Publications: 4.
tDCS Intervention in Primary Progressive Aphasia
ClinicalTrials.gov study NCT02606422. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Intervention for Communication Quality of Life in Primary Progressive Aphasia
ClinicalTrials.gov study NCT07219680. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Transcranial Direct Current Stimulation for Primary Progressive Aphasia
ClinicalTrials.gov study NCT02928848. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
Objective: To evaluate whether a quantitative speech measure is effective in identifying and monitoring motor speech impairment (MSI) in patients with primary progressive aphasia (PPA), and to investigate the neuroanatomical basis of MSI in PPA. Methods: Sixty-four patients with PPA were evaluated at baseline, with a subset (N=39) evaluated longitudinally. Articulation rate (AR), a quantitative measure derived from spontaneous speech, was measured at each timepoint. MRI was collected at baseline. Differences in baseline AR were assessed across PPA subtypes, separated by severity level. Linear mixed-effects models were conducted to assess groups differences across PPA subtypes in rate of decline in AR over a one-year period. Cortical thickness measured from baseline MRIs was used to test hypotheses about the relationship between cortical atrophy and MSI. Results: Baseline AR was reduced for patients with non-fluent variant PPA (nfvPPA), as compared to other PPA subtypes and controls, even in mild stages of disease. Longitudinal results showed a greater rate of decline in AR for the nfvPPA group over one year, as compared to logopenic and semantic variant subgroups. Reduced baseline AR was associated with cortical atrophy in left-hemisphere premotor and supplementary motor cortices. Conclusions: The AR measure is an effective quantitative index of MSI that detects MSI in mild disease stages and tracks decline in MSI longitudinally. The AR measure additionally demonstrates anatomic localization to motor-speech specific cortical regions. Our findings suggest that this quantitative measure of MSI might have utility in diagnostic evaluation and monitoring of motor speech impairments in PPA.
Data from: Primary progressive aphasias and GRN mutations
<p><strong>Objective:</strong> To determine relative frequencies and linguistic profiles of primary progressive aphasia (PPA) variants associated with progranulin (GRN) mutations, and study their neuroanatomical correlates.</p> <p><strong>Methods:</strong> PPA patients carrying GRN mutations (PPA-GRN) were selected amongst a national prospective research cohort of 1,696 frontotemporal dementia (FTD) patients, including 235 patients with PPA. All PPA patients with amyloid-positive CSF biomarkers were excluded. In this cross-sectional study, speech/language and cognitive profiles were characterized with standardized evaluations, and grey matter (GM) atrophy patterns using voxel-based morphometry. Comparisons were performed with controls, and sporadic PPA patients.</p> <p><strong>Results:</strong> Among the overall population of 235 patients, 45 (19%) carried GRN mutations. We studied 32 of these and showed that logopenic PPA (lvPPA) was the most frequent linguistic variant (13, 41%), followed by non-fluent/agrammatic (nfvPPA: 9, 28%) and mixed forms (8, 25%). Semantic variant was rather rare (2, 6%). LvPPA patients, qualified as non-amyloid-lvPPA, presented canonical logopenic deficit. Seven out of 13 had a pure form, six showed subtle additional linguistic deficits not fitting criteria for mixed PPA, hence labelled as "logopenic-spectrum variant". GM atrophy primarily involved left posterior temporal gyrus, mirroring neuroanatomical changes of amyloid-positive-lvPPA. NfvPPA patients presented agrammatism (89%) rather than apraxia of speech (11%).</p> <p><strong>Conclusions:</strong> This study shows that most frequent PPA variant associated with GRN mutations is non-amyloid lvPPA, preceding nfvPPA and mixed forms, and illustrates that language network may be affected at different levels. GRN testing is indicated for PPA patients, whether familial or sporadic. This finding is important for upcoming GRN gene-specific therapies.</p>
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
ClinicalTrials.gov study NCT05368350. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long-term Effect of TMS in Primary Progressive Aphasia
ClinicalTrials.gov study NCT05842473. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Propranolol in Primary Progressive Aphasia
ClinicalTrials.gov study NCT06066710. IPD Sharing: NO. Countries: 1. Publications: 13.
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
ClinicalTrials.gov study NCT05741853. IPD Sharing: YES. Countries: 2. Publications: 15.
Language in Primary Progressive Aphasia
ClinicalTrials.gov study NCT00537004. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Transcranial Magnetic Stimulation in Primary Progressive Aphasia
ClinicalTrials.gov study NCT03580954. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Treatment for Speech and Language in Primary Progressive Aphasia
ClinicalTrials.gov study NCT04881617. IPD Sharing: NO. Countries: 1. Publications: 3.
Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia
ClinicalTrials.gov study NCT05901233. IPD Sharing: NO. Countries: 1. Publications: 3.
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
ClinicalTrials.gov study NCT05386394. IPD Sharing: Not stated. Countries: 2. Publications: 8.
A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia
ClinicalTrials.gov study NCT03174886. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
rTMS Treatment of Primary Progressive Aphasia
ClinicalTrials.gov study NCT04431401. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia
ClinicalTrials.gov study NCT02675270. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
ClinicalTrials.gov study NCT05615922. IPD Sharing: YES. Countries: 1. Publications: 0.
Home-Based Exercise in Primary Progressive Aphasia (HEPPA)
ClinicalTrials.gov study NCT06181500. IPD Sharing: NO. Countries: 1. Publications: 40.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.