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A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"

ClinicalTrials.gov study NCT05304221. IPD Sharing: NO. Countries: 1. Publications: 10.

Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease

ClinicalTrials.gov study NCT02366845. IPD Sharing: Not stated. Countries: 1. Publications: 9.

Prospective, Multicenter, Self-controlled Clinical Trial to Validate Optical Ultrasonic Flow Ratio (OUFR)

ClinicalTrials.gov study NCT06726252. IPD Sharing: NO. Countries: 1. Publications: 3.

controlledIPD-YESFeb 2026View details →

Prospective Validation of the Emergency Heart Failure Mortality Risk Grade (EHMRG) Score in Patients With Acute Heart Failure in the Emergency Department

ClinicalTrials.gov study NCT05710302. IPD Sharing: YES. Countries: 1. Publications: 4.

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Development and validation of a postoperative delirium prediction model for patients admitted to an intensive care unit in China: a prospective study

Objectives: We aimed to develop and validate a postoperative delirium (POD) prediction model for patients admitted to the intensive care unit (ICU). Design: A prospective study was conducted. Setting: The study was conducted in the surgical, cardiovascular surgical, and trauma surgical ICUs of an affiliated hospital of a medical university in Heilongjiang Province, China. Participants: This study included 400 patients (≥18 years old) admitted to the ICU after surgery. Primary and secondary outcome measures: The primary outcome measure was postoperative delirium assessment during ICU stay. Results: The model was developed using 300 consecutive ICU patients and was validated using 100 patients from the same ICUs. The model was based on five risk factors: Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity; acid-base disturbance; and history of coma, diabetes, or hypertension. The model had an area under the receiver operating characteristics curve of 0.852 (95% confidence interval: 0.802–0.902), Youden index of 0.5789, sensitivity of 70.73%, and specificity of 87.16%. The Hosmer-Lemeshow goodness of fit was 5.203 (P = 0.736). At a cut-off of 24.5%, the sensitivity and specificity were 71% and 69%, respectively. Conclusions: The model, which used readily available data, exhibited high predictive value regarding risk of intensive care unit postoperative delirium (ICU-POD) at admission. Use of this model may facilitate better implementation of preventive treatments and nursing measures.

opencc-zeroOct 2019View details →

dryad32/100

Data from: Validation of the hospital frailty risk score in a tertiary care hospital in Switzerland: results of a prospective, observational study

Objectives: Recently, the Hospital Frailty Risk Score based on a derivation and validation study in the United Kingdom has been proposed as a low-cost, systematic screening tool to identify older, frail patients who are at greater risk of adverse outcomes and for whom a frailty-attuned approach might be useful. We aimed to validate this Score in an independent cohort in Switzerland. Design: Secondary analysis of a prospective, observational study (TRIAGE study). Setting: One 600-bed tertiary care hospital in Aarau, Switzerland Participants: Consecutive medical inpatients aged 75 years or older that presented to the emergency department or were electively admitted between October 2015 and April 2018. Primary and secondary outcome measures: The primary endpoint was all-cause 30-day mortality. Secondary endpoints were length of hospital stay, hospital readmission, functional impairment, and quality of life measures. We used multivariate regression analyses. Results: Of 4957 included patients, 3150 (63.5%) were classified as low risk, 1663 (33.5%) intermediate risk, and 144 (2.9%) high risk for frailty. Compared to the low-risk group, patients in the moderate risk and high-risk groups had increased risk for 30-day mortality (odds ratio [OR] 2.53, 95%CI 2.09 to 3.06, P<0.001 and OR 4.40, 95%CI 2.94 to 6.57, P<0.001) with overall moderate discrimination (area under the ROC curve 0.66). The results remained robust after adjustment for important confounders. Similarly, we found longer length of hospital stay, more severe functional impairment and a lower quality of life in higher risk group patients. Conclusion: Our data confirms the prognostic value of the Hospital Frailty Risk Score to identify older, frail people at risk for mortality and adverse outcomes in an independent patient population. Trial registration number: ClinicalTrials.gov; Identifier: NCT01768494

opencc-zeroDec 2017View details →

controlledIPD-YESFeb 2026View details →

Cohort Study of Prospective Validation of Predictive Factors and Biological Imaging of Response to Bevacizumab and Paclitaxel in Patients With Metastatic Breast Cancer

ClinicalTrials.gov study NCT01745757. IPD Sharing: YES. Countries: 1. Publications: 3.

A Prospective Natural History and Outcome Measure Validation Study of Congenital Myasthenic Syndromes

ClinicalTrials.gov study NCT06630650. IPD Sharing: NO. Countries: 1. Publications: 37.

Enhanced Diagnostics for Early Detection of Atrial Fibrillation - Prospective Validation

ClinicalTrials.gov study NCT02949180. IPD Sharing: NO. Countries: 2. Publications: 2.

Prospective Study to Validate the Imaging Biomarker for NCP (R33)

ClinicalTrials.gov study NCT05653921. IPD Sharing: NO. Countries: 1. Publications: 8.

Validation of an AI-based Biliopancreatic EUS Navigation System for Real-time Quality Improvement: A Prospective, Single-center, Randomized Controlled Trial

ClinicalTrials.gov study NCT05457101. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR

ClinicalTrials.gov study NCT04139616. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.

A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA

ClinicalTrials.gov study NCT01686776. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure

ClinicalTrials.gov study NCT05518396. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.

Single-center Prospective Study to Validate the Performance of the Aktiia Optical Blood Pressure Monitoring (OBPM) Device at the Wrist Against Ambulatory Blood Pressure Monitoring (ABPM)

ClinicalTrials.gov study NCT04548986. IPD Sharing: NO. Countries: 1. Publications: 1.

Prospective Validation of the OHI Index

ClinicalTrials.gov study NCT05882175. IPD Sharing: NO. Countries: 1. Publications: 1.

Prospective Validation of the ADNEX Model for Discrimination Between Benign and Malignant Adnexal Masses in Pregnancy: International Ovarian Tumour Analysis in Pregnancy Study (p-IOTA)

ClinicalTrials.gov study NCT05974618. IPD Sharing: NO. Countries: 1. Publications: 47.

Prospective Validation of Intraoperative Blood Pressure Monitors

ClinicalTrials.gov study NCT06518980. IPD Sharing: NO. Countries: 1. Publications: 22.

Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort

ClinicalTrials.gov study NCT03488043. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.

Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors

ClinicalTrials.gov study NCT06214611. IPD Sharing: NO. Countries: 1. Publications: 1.