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40 results for “psychedelics”
Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior
<p>Psychedelics have experienced renewed interest following studies suggesting potential therapeutic effects in patients with affective disorders. While clinical results look promising, the neurobiological mechanisms underlying acute and prolonged effects of psychedelics remain unclear. Many psychiatric disorders involve hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The paraventricular nucleus of the hypothalamus (PVN) is a midline hypothalamic nucleus that plays an integral role in HPA stress reactivity, autonomic functioning, social behavior, and many other affective processes. We investigated the effect of psilocin, the psychoactive metabolite of psilocybin, on PVN reactivity in Sprague Dawley rats. Psilocin increased stimulus-independent activity as measured by c-Fos expression in the PVN of male and female rats. Psilocin also increased PVN reactivity (ΔF/F) to an aversive air-puff stimulus in males but not females. PVN reactivity was restored at 2- and 7-days post-injection with no group differences. Additionally, we found that prior psilocin injection did not affect PVN reactivity following acute restraint stress. Experimental groups were sub-classified by baseline threat responding and psilocin-induced increases in male PVN reactivity were found to be driven by baseline active threat responders. Overall, these data demonstrate that the PVN is a significant site of psychedelic drug action with implications for threat responding behavior.</p>
Data and Code for "A lasting impact of serotonergic psychedelics on visual processing and behavior"
<p>Processed data and analysis code for "<span><span>A lasting impact of serotonergic psychedelics on visual processing and behavior". <span>https://doi.org/10.1101/2024.07.03.601959 </span></span></span></p>
Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior
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Resting-state functional connectivity matrices of various unconscious, psychedelic, and neuropsychiatric states.
<p>Functional connectivity matrices of various unconscious, psychedelic, and neuropsychiatric states.</p> <p>Conditions include:</p> <p>N2 Sleep</p> <p>Subaneshesthetic ketamine</p> <p>Deep sedation with propofol</p> <p>Surgical-level propofol anesthesia</p> <p>LSD</p> <p>N2O </p> <p>ADHD</p> <p>Bipolar disorder</p> <p>Schizophrenia</p> <p>Functional connectivity matrices with and without global signal regression are both included.</p>
Increased signal diversity/complexity of spontaneous EEG, but not evoked EEG responses, in ketamine-induced psychedelic state in humans
<p>How and to what extent electrical brain activity reflects pharmacologically altered states and contents of consciousness, is not well understood. Therefore, we investigated whether measures of evoked and spontaneous electroencephalographic (EEG) signal diversity are altered by sub-anaesthetic levels of ketamine compared to normal wakefulness, and how these measures relate to subjective experience.</p> <p>High-density 62-channel EEG was used to record spontaneous brain activity and responses evoked by transcranial magnetic stimulation (TMS) in 10 healthy volunteers before and during administration of sub-anaesthetic doses of ketamine in an openlabel within-subject design. Evoked signal diversity was assessed using the perturbational complexity index (PCI), calculated from EEG responses to TMS perturbations. Signal diversity of spontaneous EEG, with eyes open and eyes closed, was assessed by Lempel Ziv complexity (LZc), amplitude coalition entropy (ACE), and synchrony coalition entropy (SCE).</p> <p>Although no significant difference was found in TMS-evoked complexity (PCI) between the sub-anaesthetic ketamine condition and normal wakefulness, all measures of spontaneous EEG signal diversity (LZc, ACE, SCE) showed significantly increased values in the sub-anaesthetic ketamine condition. This increase in signal diversity correlated with subjective assessment of altered states of consciousness. Moreover, spontaneous signal diversity was significantly higher when participants had eyes open compared to eyes closed, both during normal wakefulness and during influence of subanaesthetic ketamine.</p> <p>The results suggest that PCI and spontaneous signal diversity may reflect distinct, complementary aspects of changes in brain properties related to altered states of consciousness: the brain's capacity for information integration, assessed by PCI, might be indicative of the brain's ability to sustain consciousness, while spontaneous complexity, as measured by EEG signal diversity, may be indicative of the complexity of conscious content. Thus, sub-anaesthetic ketamine may increase the complexity of the conscious content and the brain activity underlying it, while the level or general capacity for consciousness remains largely unaffected.</p>
PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm
ClinicalTrials.gov study NCT06798636. IPD Sharing: YES. Countries: 1. Publications: 9.
Mindfulness and Psychedelics
ClinicalTrials.gov study NCT05780216. IPD Sharing: NO. Countries: 1. Publications: 1.
Microdosing Psychedelics to Improve Mood
ClinicalTrials.gov study NCT05259943. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Psychedelics and Wellness Study (PAWS)
ClinicalTrials.gov study NCT04040582. IPD Sharing: NO. Countries: 1. Publications: 1.
Investigation of Psychedelic Effects in Psychoactive Substances
ClinicalTrials.gov study NCT06772753. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
ClinicalTrials.gov study NCT06815653. IPD Sharing: YES. Countries: 1. Publications: 0.
Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids
ClinicalTrials.gov study NCT04965740. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Increased signal diversity/complexity of spontaneous EEG, but not evoked EEG responses, in ketamine-induced psychedelic state in humans
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Data from: Psychedelic mushrooms in the USA: knowledge, patterns of use, and association with health outcomes
<p>This was a cross-sectional nationwide survey of adults in the US in 2021. The survey targeted a representative sample of US adults. The rate of psychedelic us, comorbid conditions, mental and physical health, and factors predictive of psychedlic use were assessed.</p>
Structural Insights into Tryptamine Psychedelics: The Role of Hydroxyl Indole Ring Site in 5-HT2A Receptor Activation and Psychedelic-like Activity
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Neural Correlates of Psychedelic, Sleep, and Sedated States Support Global Theories of Consciousness
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Data from: Psychedelic mushrooms in the USA: knowledge, patterns of use, and association with health outcomes
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Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice
GEO Series GSE161626. Mus musculus. 84 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Psychedelic control of neuroimmune interactions governing fear
GEO Series GSE262989. Homo sapiens; Mus musculus. 108 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Analysis of psychedelic control of primary human monocytes
GEO Series GSE262982. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.