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749 results for “pulmonary artery”
Blood DNA Methylation Profiling Identifies Cathepsin Z Dysregulation in Pulmonary Arterial Hypertension
<p>Ulrich, A., Wu, Y., Draisma, H., Wharton, J., Swietlik, E. M., Cebola, I., Vasilaki, E., Balkhiyarova, Z., Jarvelin, M. R., Auvinen, J., Herzig, K. H., Coghlan, J. G., Lordan, J., Church, C., Howard, L. S., Pepke-Zaba, J., Toshner, M., Wort, S. J., Kiely, D. G., Condliffe, R., … Rhodes, C. J. (2024). <a href="https://pubmed.ncbi.nlm.nih.gov/38184627/"><strong>Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension</strong></a>. <em>Nature communications</em>, <em>15</em>(1), 330. https://doi.org/10.1038/s41467-023-44683-0</p> <p>Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.</p>
New protein production in primary pulmonary artery endothelial cells treated with insulin-like growth factor 1 treatment
<p>Maximum projections of flat-fielded and deconvolved epi-fluorescence imaging data for primary sheep pulmonary artery endothelial cells (PAEC) treated with vehicle or insulin-like growth factor 1 (IGF1) media.</p> <p>Two cell types: normal PAEC and persistent pulmonary hypertension of the newborn (PPHN) PAEC</p> <p>Three time points: 0 minutes, 1 hour, and 24 hours post-treatment</p> <p>Two fluorescence channels:<br> C0 - DAPI for nuclei (R37606, Life Technologies)<br> C1 - Click-IT new protein translation kit (C10428, C10429, Life Technologies)</p>
Ensemble and single cell data for primary Ovis Aries pulmonary artery endothelial cells response to IGF-1 administration
<p>Data for IGF-1 administration of healthy and persistent pulmonary hypertension of the newborn primary Ovis Aries pulmonary artery endothelial cells.</p> <p>Ensemble.zip:<br> Dose-response to IGF-1<br> Proliferation<br> Western blots for VEGF and eNOS<br> IGF-1R and mTOR inhibition<br> Branch points in tube formation assay<br> <br> IF.zip:<br> Cellprofiler 3.1 analysis of snapshot data for the time course of IGF-1 administration with nuclei, actin, VEGF, and eNOS</p> <p>Translation.zip:<br> CellProfiler 3.1 analysis of snapshot data for the time course of IGF-1 administration with nuclei and total protein production</p>
Data manuscript: Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension
<p>Supporting Information files of manuscript: Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension </p> <p> </p> <p>The values behind the means, standard deviations and values used to build graphs; </p>
Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT00147199. IPD Sharing: Not stated. Countries: 10. Publications: 1.
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
ClinicalTrials.gov study NCT01042158. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
ClinicalTrials.gov study NCT02024386. IPD Sharing: Not stated. Countries: 1. Publications: 31.
Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT02471183. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT00323297. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT01392495. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH)
ClinicalTrials.gov study NCT02290613. IPD Sharing: Not stated. Countries: 1. Publications: 3.
PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol)
ClinicalTrials.gov study NCT01586156. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Incorporating the Venous Excess Ultrasound Score (VExUS Score) Into Contemporary Haemodynamic Risk Assessment in Pulmonary Arterial Hypertension: The INVEXUS-PAH Study
ClinicalTrials.gov study NCT07266012. IPD Sharing: YES. Countries: 1. Publications: 3.
ACT-293987 in Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT01112306. IPD Sharing: Not stated. Countries: 38. Publications: 1.
Selonsertib in Adults With Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT02234141. IPD Sharing: Not stated. Countries: 8. Publications: 1.
A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children
ClinicalTrials.gov study NCT00159874. IPD Sharing: Not stated. Countries: 15. Publications: 3.
To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.
ClinicalTrials.gov study NCT00430716. IPD Sharing: YES. Countries: 17. Publications: 1.
DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study
ClinicalTrials.gov study NCT01321073. IPD Sharing: NO. Countries: 1. Publications: 5.
Study of a New Thermo Stable Formulation of Epoprostenol Sodium to Treat Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT01462565. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT00887978. IPD Sharing: Not stated. Countries: 12. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.