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5 results for “pulsatile hemodynamics”
Data from: The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics
<p>Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. If left untreated, by the time individuals reach 50 years of age, the mortality rate can reach 90%. Previous studies have highlighted the adverse effects of CoA on local hemodynamics. However, no study has investigated the global hemodynamic effects of CoA in end-organ (brain and kidney) damage. Clinical studies have shown that coarctation acts as a reflection site, potentially damaging the hemodynamics of the brain and kidneys. Our goal in this study is to investigate the underlying mechanisms of these altered wave dynamics and their impacts on the pulsatile hemodynamics of end-organs. In this study, we use a physiologically accurate in-vitro experimental setup that simulates the hemodynamics of systemic circulation. Experiments are conducted across various cardiac outputs, heart rates, and coarctation degrees using aortas across a wide range of aortic stiffnesses. Our principal finding is that CoA increases cerebral blood flow and harmful pulsatile energy transmission to the brain. Conversely, both renal blood flow and pulsatile energy transmission to the kidneys are reduced in CoA at every level of aortic stiffness.</p>
Data from: The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics
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Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure
ClinicalTrials.gov study NCT00720525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease
ClinicalTrials.gov study NCT02791906. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
ClinicalTrials.gov study NCT04233957. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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