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31
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ShareScore release 0.7.1
Dataset results
31 results for “pyridoxine”
Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer
ClinicalTrials.gov study NCT00296036. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo
ClinicalTrials.gov study NCT05221892. IPD Sharing: NO. Countries: 1. Publications: 10.
Study of Pyridoxine for Hand-Foot Syndrome
ClinicalTrials.gov study NCT00446147. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Addition of Pyridoxine to Prednisolone in Infantile Spasms
ClinicalTrials.gov study NCT01828437. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation by a Vineland II Scale of Long-term Development of Children With Pyridoxine Dependent Epilepsy
ClinicalTrials.gov study NCT06054347. IPD Sharing: NO. Countries: 1. Publications: 6.
Pyridoxine Effect on the Blood Glucose Level in Type 2 Diabetic Patients
ClinicalTrials.gov study NCT05918068. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pyridoxine in Preventing Hand-Foot Syndrome Caused by Capecitabine in Patients With Cancer
ClinicalTrials.gov study NCT00486213. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ondansetron VS Doxylamine and Pyridoxine in Treating Nausea of Pregnancy
ClinicalTrials.gov study NCT01668069. IPD Sharing: NO. Countries: 1. Publications: 1.
Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia
ClinicalTrials.gov study NCT03287778. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients
ClinicalTrials.gov study NCT01795170. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Data from: Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy
Objective: To evaluate the features and maturational changes in overall callosal shape in patients with pyridoxine-dependent epilepsy (PDE). Methods: Measurements were conducted through landmark based geometric morphometrics applied on cerebral MRIs of PDE patients and age-matched control subjects. The outline of the corpus callosum was manually traced in the midsagittal plane. 300 semi-landmarks along the outline were collected and underwent statistical generalized Procrustes analysis. An allometric regression was applied to evaluate the callosal shape due to growth over time. Results: 38 patients with PDE and 38 age- and sex-matched control subjects were included. Mean age at the time of the MRI in the patient group was 9.3 years (median 6.3 years, range 0.01- 48 years). Significant differences (p<0.01) in the mean callosal shape between patients and controls were found. The allometric regression model revealed significant shape variations (p<0.01) between the two study groups across the developmental course after controlling for the effect of callosal size on shape. This latter effect turned out to be significant as well (p<0.001). Conclusions: Patients with PDE show an altered callosal shape and variations in callosal ontogeny which are likely secondary to the underlying genetic defect with abnormal function of antiquitin, the product of the ALDH7A1 gene.
Data from: 8-way randomized controlled trial of doxylamine, pyridoxine and dicyclomine for nausea and vomiting during pregnancy: restoration of unpublished information
Objectives: We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy. We are publishing the trial's findings according to the restoring invisible and abandoned trials (RIAT) initiative because the trial was never published. Design: Double blinded, multi-centred, randomized placebo-controlled study. Setting: 14 clinics in the United States. Participants: 2308 patients in the first 12 weeks of pregnancy with complaints of nausea or vomiting were enrolled. Interventions: Each patient was randomized to one of eight arms: placebo, doxylamine/pyridoxine/dicylcomine, doxylamine/pyridoxine, dicylomine/pyridoxine, doxylamine, dicyclomine/pyridoxine, pyridoxine and dicyclomine. Each patient was instructed to take 2 tablets at bedtime and 1 additional tablet in the afternoon or morning if needed, for 7 nights. Outcomes: Reported outcomes included the number of hours of nausea reported by patients, the frequency of vomiting reported by patients and the overall efficacy of medication as judged by physicians. Results: Data from 1599 (69% of those randomized) participants were analyzed. Based on the available summary data of physician evaluation of symptoms and ignoring missing data and data integrity issues, the proportion of participants who were "evaluated moderate or excellent" was greater in each of the seven active treatment groups when compared with placebo (57%): doxylamine/pyridoxine/dicylcomine (14% absolute difference versus placebo; 95% CI: 4 to 24), doxylamine/pyridoxine (21; 95% CI 11 to 30), dicylomine/pyridoxine (21; 95% CI 11 to 30), doxylamine (20; 95% CI 10 to 29), dicyclomine/pyridoxine (4; 95% CI -6 to 14), pyridoxine (9; 95% CI -1 to 19) and dicyclomine (4; 95% CI -6 to 14). Based on incomplete information, the most common adverse events were apparently drowsiness and fatigue. There is a high risk of bias in these previously unpublished results given the high attrition rate in a 7 day trial, the lack of prespecified outcomes or analyses, and the exclusion of some data because of questionable data integrity. Conclusion: The available information about this "8-way Bendectin" trial indicates it should not be used to support the efficacy of doxylamine, pyridoxine or dicyclomine for the treatment of nausea and vomiting during pregnancy because of a high risk of bias.
Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind
ClinicalTrials.gov study NCT03221816. IPD Sharing: Not stated. Countries: 0. Publications: 12.
Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer
ClinicalTrials.gov study NCT00245050. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: 8-way randomized controlled trial of doxylamine, pyridoxine and dicyclomine for nausea and vomiting during pregnancy: restoration of unpublished information
Open the record for dataset details and reuse information.
Data from: Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy
Open the record for dataset details and reuse information.
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
GEO Series GSE143164. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of Muscle Stem cells from aged mice following treatment with the combination of nicotinamide (NAM) and pyridoxine (PN) for 3 days.
GEO Series GSE269250. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of human myogenic progenitors following treatment with nicotinamide (NAM) or pyridoxine (PN) or the combination (NAM/PN).
GEO Series GSE264285. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Targeting AASS improves neurotoxicity and mitochondrial function in astrocyte models for pyridoxine dependent epilepsy
GEO Series GSE287216. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
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