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3 results for “qDESS”
Data from: A Method for Measuring B0 Field Inhomogeneity using Quantitative DESS (qDESS)
<p><strong>Purpose</strong>: To develop and validate a method for B0 mapping for knee imaging using the quantitative Double-Echo in Steady-State (qDESS) exploiting the phase difference (∆θ) between the two echoes acquired. Contrary to a standard two-gradient echo (2-GRE) method, the phase accumulation in qDESS depends only on the first echo time.</p> <p><strong>Methods:</strong> Bloch simulations were applied to investigate the robustness to noise of the proposed methodology and all imaging studies were validated with phantoms and in vivo simultaneous bilateral knee acquisitions. Two phantoms and 5 healthy subjects were scanned using qDESS, water saturation shift referencing (WASSR), and multi GRE sequences. ∆B0 maps were calculated with the qDESS and the 2-GRE methods and compared against those obtained with WASSR. The comparison was quantitatively assessed by exploiting pixel-wise difference maps, Bland-Altman (BA) analysis, and Lin’s concordance coefficient (ρc). For in-vivo subjects, the comparison was assessed in cartilage using average values in 6 sub-regions.</p> <p><strong>Results:</strong> The proposed method for measuring B0 inhomogeneities in phantom and in-vivo scans from a qDESS acquisition provided ∆B0 maps that were in good agreement with those obtained using WASSR. ∆B0 Lin’s coefficients were greater than or equal to 0.98 and 0.90 in phantoms and in vivo, respectively. The agreement between qDESS and WASSR was comparable to that of a standard 2-GRE method. Conclusion: The proposed method may allow B0 correction for qDESS T2 mapping using an inherently co-registered ∆B0 map without requiring an additional B0 measurement sequence. More generally, the method may help shorten knee imaging protocols that require an auxiliary ∆B0 map by exploiting a qDESS acquisition that also provides T2 measurements and high-quality morphological imaging.</p> <p><strong>Conclusion:</strong> The proposed method may allow B0 correction for qDESS T2 mapping using an inherently co-registered ∆B0 map without requiring an additional B0 measurement sequence. More generally, the method may help shorten knee imaging protocols that require an auxiliary ∆B0 map by exploiting a qDESS acquisition that also provides T2 measurements and high-quality morphological imaging.</p> <p><strong>This repository contains the data for reproducing the results reported in the paper. For the in-vivo data, python scripts are provided to perform the data analysis described in the paper. The data are provided in NIFTI format. </strong></p> <p><strong>Please cite the original paper (10.1002/mrm.29465) and this repository if you use any of the data or code contained here.</strong></p> <p> </p>
Data From: B1 Field inhomogeneity correction for qDESS T2 mapping: application to rapid bilateral knee imaging
<p><strong>Purpose</strong>: T2 mapping is a powerful tool for studying osteoarthritis (OA) changes and bilateral imaging may be useful in investigating the role of between-knee asymmetry in OA onset and progression. The quantitative double-echo in steady-state (qDESS) can provide fast simultaneous bilateral knee T2 and high-resolution morphometry for cartilage and meniscus.<br> The qDESS uses an analytical signal model to compute T2 relaxometry maps, which require knowledge of the flip angle (FA). <br> In the presence of B1 inhomogeneities, inconsistencies between the nominal and actual FA can affect the accuracy of T2 measurements.<br> We propose a pixel-wise B1 correction method for qDESS T2 mapping exploiting an auxiliary B1 map to compute the actual FA used in the model.<br> <br> <strong>Methods</strong>: The technique was validated in a phantom and in vivo with simultaneous bilateral knee imaging. <br> T2 measurements of femoral cartilage (FC) of both knees of six healthy participants were repeated longitudinally to investigate the association between T2 variation and B1.</p> <p><strong>Results</strong>: The results showed that applying the B1 correction mitigated T2 variations that were driven by B1 inhomogeneities. <br> Specifically, T2 left-right symmetry increased following the B1 correction (rc = 0.74 > rc = 0.69). Without the B1 correction, T2 values showed a linear dependence with B1. The linear coefficient decreased using the B1 correction (from 24.3 <span class="math-tex">\(\pm\)</span> 1.6 ms to 4.1 <span class="math-tex">\(\pm\)</span> 1.8) and the correlation was not statistically significant after the application of the Bonferroni correction (p-value > 0.01).<br> <br> <strong>Conclusion</strong>: the study showed that B1 correction could mitigate variations driven by the sensitivity of the qDESS T2 mapping method to B1, therefore increasing the sensitivity to detect real biological changes. The proposed method may improve the robustness of bilateral qDESS T2 mapping, allowing for an accurate and more efficient evaluation of OA pathways and pathophysiology through longitudinal and cross-sectional studies.</p> <p><strong>This repository contains the raw data for reproducing the results reported in the paper. The data are provided in NIFTI format. The repository also contains the MALTAB scripts used to compute B<sub>1</sub> maps from the NIFTI data.</strong></p>
Data From: B1 Field inhomogeneity correction for qDESS T2 mapping: application to rapid bilateral knee imaging
<p>T2 mapping is a powerful tool for studying osteoarthritis (OA) changes and bilateral imaging may be useful in investigating the role of between-knee asymmetry in OA onset and progression. The quantitative double-echo in steady-state (qDESS) can provide fast simultaneous bilateral knee T2 and high-resolution morphometry for cartilage and meniscus. The qDESS uses an analytical signal model to compute T2 relaxometry maps, which require knowledge of the flip angle (FA). In the presence of B1 inhomogeneities, inconsistencies between the nominal and actual FA can affect the accuracy of T2 measurements.</p> <p>We propose a pixel-wise B1 correction method for qDESS 2 mapping exploiting an auxiliary B1 map to compute the actual FA used in the model. The technique was validated in a phantom and in vivo with simultaneous bilateral knee imaging. T2 measurements of femoral cartilage (FC) of both knees of a healthy participant were repeated longitudinally to investigate the association between T2 variation and B1. The results showed that applying the B1 correction could mitigate T2 variations that were driven by B1 inhomogeneities. Specifically, T2 left-right symmetry increased following the B1 correction. Without the B1 correction, T2 values showed a significant (p<0.05) moderate Pearson’s correlation with B1 across time points (0.68 <r<0.70 and 0.74<r<0.79, for the left and right knee, respectively). The correlations and slopes decreased using the B1 correction (0.01<r<0.02 and 0.48<r<0.55, for left and right knee, respectively) and were not statistically significant (p > 0.05). In conclusion, the study showed that B1 correction could mitigate variations driven by the sensitivity of the qDESS T2 mapping method to B1, therefore increasing the sensitivity to detect real biological changes.</p> <p>The proposed method may improve the robustness of bilateral qDESS T2 mapping, allowing for an accurate and more efficient evaluation of OA pathways and pathophysiology through longitudinal and cross-sectional studies.</p> <p><strong>This repository contains the raw data for reproducing the results reported in the paper. The data are provided in NIFTI format.</strong></p> <p> </p>
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