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124 results for “radioactivity”
Bedrock radioactivity influences the rate and spectrum of mutation - Orthologous genes
<p>Alignments of the 2490 orthologous genes used in the article "Natural Bedrock radioactivity influences the rate and spectrum of mutation" to estimate the mutational spectrum and synonymous substitution rate.</p> <p>To compute accurate synonymous substitution rate, we removed genes with short sequences (<half of the alignment) and genes strongly supporting another phylogeny using ProfileNJ <a href="https://paperpile.com/c/Klqlpb/W5sS">(Noutahi et al. 2016)</a> with a bootstrap threshold of 90%, resulting in a subset of 769 genes listed in the file "List_769_1-to-1_orthologs_EvolutionRate.txt".</p> <p>Transcriptome paired-end reads used to define these orthologous genes have been deposited to the European Nucleotide Archive and are available under the study ID PRJEB14193.</p> <p>Sequences were aligned with Prank<a href="https://paperpile.com/c/Klqlpb/pilh"> (Löytynoja & Goldman 2008)</a> using a codon model and sites ambiguously aligned were removed with Gblocks <a href="https://paperpile.com/c/Klqlpb/c5kb">(Castresana 2000)</a>.</p>
Dataset of a multiphase flow and reactive transport benchmark for radioactive waste disposal
<p>The files include the full dataset (tables and figures) of the comparion the results of a multiphase flow and reactive transport<br>benchmark for radioactive waste disposal. The codes INVERSE-FADES-CORE V2, DuMuX , TOUGHREACT and<br>iCP were benchmarked with 6 test cases of increasing complexity, starting with conservative tracer transport under variably<br>unsaturated conditions and ending with water flow, gas diffusion, minerals and cation exchange.</p>
Molecular sidebands for radioactive ion beam extraction
<p>Summary of potential radioactive molecular ion beams seen and predicted from ISOL targets and ion sources including data compiled from [1] and [2]. Some of the molecules (e.g. the transition metal carbonyl or oxide compounds or COTe) are conceptual and would require ion source developments. The actinides other than U are predicted to form compounds with a variety of valence states and require beam developments. Plasma or electron bombardment ion sources may cause molecular fragmentation and change availability of molecular sidebands.</p> <p>[1] U. Köster et al., <em>NIMB </em><strong>266</strong>, 10.1016/J.NIMB.2008.05.152 (2008)</p> <p>[2] J. Ballof, <em>Radioactive Molecular Beams at CERN-ISOLDE,</em> PhD thesis, JGU Mainz (2021)</p>
Genomic insights into the Archaea inhabiting an Australian radioactive legacy site
<p><strong>Abstract</strong></p> <p>During the 1960s, small quantities of radioactive materials were co-disposed with chemical waste at the Little Forest Legacy Site (LFLS, Sydney, Australia). The microbial function and population dynamics during a rainfall event using shotgun metagenomics has been previously investigated. This revealed a broad abundance of candidate and potentially undescribed taxa in this iron-rich, radionuclide-contaminated environment.</p> <p>Here, applying genome-based metagenomic methods, we recovered 37 refined archaeal bins (≥50% completeness, ≤10% redundancy) from 10 different major lineages. They were mostly included in 4 proposed lineages within the DPANN supergroup (LFWA-I to IV) and <em>Methanoperedenaceae</em>.</p> <p>The new <em>Methanoperedens</em> spp. bins, together with previously published data, suggests a potentially widespread ability to use nitrate (or nitrite) and metal ions as electron acceptors during the anaerobic oxidation of methane by <em>Methanoperedens</em> spp.</p> <p>While most of the new DPANN lineages show reduced genomes with limited central metabolism typical of other DPANN, the candidate species from the proposed LFWA-III lineage show some unusual features not often present in DPANN genomes, i.e. a more comprehensive central metabolism and anabolic capabilities.While there is still some uncertainty about the capabilities of LFW-121_3 and closely related archaea for the biosynthesis of nucleotides <em>de novo</em>, and amino acids, it is to date the most promising candidate to be the first <em>bona fide</em> free-living DPANN archaeon.</p> <p><strong>Repository Contents</strong></p> <p><em>genomes.tar:</em> includes each of the reference and novel assembled MAG/bins used for analysis in the main manuscript as .tar.gz compressed folders. Each genome folder contains the output from:</p> <ul> <li>Anvi'o,</li> <li>EggNOG analysis with arNOG library,</li> <li>InterProScan analysis,</li> <li>rRNA search with Barrnap,</li> <li>output from searching high heme cytochromes (≥10 heme binding sites in a single protein),</li> <li>CAZy search output,</li> <li>MEROPS output (BLASTp),</li> <li>PSORTb, and</li> <li>TCDB.</li> </ul> <p>In the case of the new MAGs (i.e. LFW_Bin_00*, referred in the paper as LFW-*), some additional contents are included:</p> <ul> <li>tRNAs from tRNAscan-SE, and</li> <li>Prokka annotation files.</li> </ul> <p><em>pangenomics.tar</em>: includes the Anvi'o files for the pangenomic analysis of:</p> <ul> <li><em>anme-2d.tar.gz</em>: pangenome of <em>Methanoperedens</em> spp. based on 4 reference and 6 novel MAGs clustered with an MCL inflation value of 6.0. It also includes the output of ANI analysis (via pyANI) and AAI (via CompareM).</li> <li><em>LFWA-III.tar.gz</em>: pangenome analysis of the LFWA-III lineage ('Gugararchaeaceae) based on 2 reference and 8 novel MAGs clustered at inflation values of 1.0, 1.5 and 2.0. It also includes the output of ANI analysis (via pyANI) and AAI (via CompareM).</li> </ul> <p><em>phylogeny.tar</em>: includes the files required for the phylogenomic/phylogenetic analyses shown in the paper and the Supplementary Information:</p> <ul> <li><em>rp44.tar.gz</em>: phylogenomic analysis based on 44 universal and archaeal-specific ribosomal proteins (Figure 1 in paper). It also includes annotation files for iTOL.</li> <li><em>NarG.tar.gz</em>: phylogeny of NarG and relate molybdopterin oxidoreductase proteins (Figure 5 in paper).</li> <li><em>LysJ-ArgD.tar.gz</em>: phylogeny of LysJ/ArgD proteins and their orthologous (Figure S3 in paper).</li> </ul>
Mapping of solar panels and Fukushima Daiichi Nuclear Power Plant Accident-associated radioactive waste storage in 2022 and 2023, Fukushima, Japan
<p>The policy of reconstruction after the Fukushima Daiichi Nuclear Plant accident has led to a radical transformation of the landscapes of Fukushima Prefecture especially in two aspects (Asanuma-Brice et al., 2023). The first is related to an extensive decontamination policy which resulted in the removal of more than 13 million m<sup>3</sup> of contaminated soil (MOEJ, 2021). The second is the widespread installation of solar panels, which demonstrate the transition decided by the Prefecture and the inhabitants in terms of energy policy.</p> <p>A systematic mapping of these features was carried out from the satellite imagery of Google Map (2023) within the boundaries of Fukushima Prefecture. The objective was to highlight the evolution of specific land use features that are captured imprecisely by automatic detection mapping. We focused on the main visible change in the landscape in terms of land use since Fukushima Daiichi nuclear accident: contaminated waste disposal areas and solar panel fields. These zones were delineated allowing a calculation of the corresponding surface areas (m<sup>2</sup>).<strong> The dataset is composed of 4 shapefile layers: contaminated waste deposits in 2022 and 2023, solar panels in 2022 and 2023. For the year 2022 the last update was conducted in July 2022 and for the year 2023 the last update took place in March 2023.</strong></p> <p>As the land use is in constant and rapid transition (Asanuma-Brice, 2021), we considered as contaminated waste deposits, the permanent storage centers as well as the sites where there are still bags of contaminated waste in varying numbers, knowing that they will be removed and stored on other dedicated sites (Evrard et al., 2019). This choice was made to potentially identify, when the map was updated, the future uses of the land where this waste was stored temporarily.</p> <p>This dataset is part of a larger project that aims to provide the community with an interactive tool (https://mitatelab.cnrs.fr/mitate-labs-map-of-solar-panel-and-contaminated-wasted-land/) that makes available various types of information essential to the analysis of the reconstruction, such as: the delineation of the evacuated zone (which evolved throughout time), the delineation of the municipality boundaries affected by the reconstruction policy, the main services found in these localities, the location of the memorials of the disaster in the zone, as well as the geo-localization of the soil/sediment samples collected by other Mitate lab researchers in order to investigate the redistribution of radionuclides in the environment (Evrard et al., 2021).</p>
Determination of Natural Radioactivity Levels and Associated Radiation Hazard Indices of Wheat Flour Samples From Selected Ethiopian Markets.
<p>Wheat flour is a nutrient-dense food that is commonly consumed by various age groups in Ethiopia. In this study, natural radioactivity levels of <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K, as well as the related dangerous radiological characteristics, were successfully measured on 10 different brands of wheat flour samples using high-purity germanium (HPGe) gamma-ray spectrometry. Average activity concentrations of <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K in wheat flour are found to be 0.26<strong> ±</strong>0.07 Bq.kg<sup>-1</sup>, 1.54<strong> ± </strong>0.43 Bq.kg<sup>-1</sup>, and 59.79<strong>±</strong>3.65 Bq.kg<sup>-1</sup>, respectively. Moreover, the average values of the corresponding radiological parameters, Ra<sub>eq</sub>, H<sub>int</sub>, and annual effective dose (E<sub>ave</sub>) (sum), were also found to be 7.07±0.96 Bq.kg<sup>-1</sup>, 0.019±0.003, and 0.109±0.019 mSvy<sup>-1</sup>, respectively. When the obtained results for all of the samples were compared to the internationally accepted norms, they were found to be below the permissible world average values. Furthermore, the lifetime cancer risk was discovered to be substantially below the permissible limit. According to the study, the risk of absorbing natural radionuclides from wheat flour consumption is negligible. The findings can be used to develop radiation protection rules and regulations for the use of wheat flour in food production and processing.</p>
Radioactivity York Lab
<p>Lab data for PHYS 3320 <br> The respective file names are horizontal and vertical are based on the position of GM counter <br> The integer files represent a vertical placed GM counter with varying distances in cm from the radioactive source i.e O0.5 = 0.5 cm above the radioactive source. </p> <p> </p>
Raw Data for the article: A Radioactive-Free Method for the Thorough Analysis of the Kinetics of Cell Cytotoxicity
<p>The cytotoxic activity of T cells and Natural Killer cells is usually measured with the chromium release assay (CRA), which involves the use of 51Chromium (<sup>51</sup>Cr), a radioactive substance dangerous to the operator and expensive to handle and dismiss. The accuracy of the measurements depends on how well the target cells incorporate <sup>51</sup>Cr during labelling which, in turn, depends on cellular division. Due to bystander metabolism, the target cells spontaneously release <sup>51</sup>Cr, producing a high background noise. Alternative radioactive-free methods have been developed. Here, we compare a bioluminescence (BLI)-based and a carboxyfluorescein succinimidyl ester (CFSE)-based cytotoxicity assay to the standard radioactive CRA. In the first assay, the target cells stably express the enzyme luciferase, and vitality is measured by photon emission upon the addition of the substrate d-luciferin. In the second one, the target cells are labelled with CFSE, and the signal is detected by Flow Cytometry. We used these two protocols to measure cytotoxicity induced by treatment with NK cells. The cytotoxicity of NK cells was determined by adding increasing doses of human NK cells. The results obtained with the BLI method were consistent with those obtained with the CRA- or CFSE-based assays 4 hours after adding the NK cells. Most importantly, with the BLI assay, the kinetic of NK cells' killing was thoroughly traced with multiple time point measurements, in contrast with the single time point measurement the other two methods allow, which unveiled additional information on NK cell killing pathways.</p>
Assessment of Natural Radioactivity Levels and Estimation of Radiological Hazards in Building Materials Commonly Used in Ethiopian Constructions.
<p>Natural radionuclide activity concentrations were measured in ceramic, gypsum, and brick samples from manufacturers, dealers, and construction sites in and around Addis Ababa, Ethiopia, using an HPGe detector. The study's main objectives were to assess the building material activity and health impacts. Average activity concentrations (Bq.kg<sup>-1</sup>) for <sup>226</sup>Ra in ceramic, gypsum, and brick samples were obtained as 81.19 ± 1.88, 1.34 ± 0.17, and 39.83 ± 1.21, respectively. Respective values of <sup>232</sup>Th were obtained as 166.12 ± 4.20, 0.68 ± 0.18, and 103.71 ± 3.29 and concentrations of <sup>40</sup>K were found to be 755.06 ± 16.10,15.42 ± 1.97, and 921.22 ± 24.90, respectively. Some of the materials that were tested, especially the ceramic sample, had slightly higher concentrations of radionuclides. In all samples except ceramic, Ra<sub>eq </sub>was < 370 Bq.kg<sup>-1</sup>, which is the recommended limiting dose for bulk medium. Furthermore, the corresponding radiological parameters, absorbed dose, annual effective dose equivalent, excess lifetime cancer risk (ELCR), internal (H<sub>in</sub>) and external (H<sub>ex</sub>) hazard indexes, gamma index (Iγ), and alpha index (Iα) were determined. The ELCR average values in this study are slightly higher than the global average, and the indoor and outdoor absorbed dose rates are greater than the limiting criteria of 84 and 59 nGyh<sup>-1</sup>. Therefore, especially for ceramic samples, it is important to assess their radiation potential and should be utilized in a controlled manner to decrease gamma exposure to inhabitants. Finally, the computed data could be used as a baseline to look at any radiological contamination caused by construction materials in the future.</p>
Measurements of natural radioactivity levels and associated radiation hazard indices in Moringa plant leaf samples from selected areas in southern Ethiopia.
<p>Moringa stenopetala (MS) is a multipurpose tree whose leaf is consumed by people of all ages in southern Ethiopia. In this study, natural radioactivity levels of <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K, as well as the related dangerous radiological characteristics, were measured on different sites of moringa samples using high-purity germanium (HPGe) gamma-ray spectrometry. Average activity concentrations of <sup>226</sup>Ra, <sup>232</sup>Th, and <sup>40</sup>K in moringa leaves are found to be 0.49 ± 0.12, 3.84 ± 1.12, and 573.29 ± 26.79 Bq.kg<sup>-1</sup>, respectively. Moreover, the average values of the corresponding radiological parameters, Ra<sub>eq</sub>, H<sub>int</sub>, and annual effective dose (E<sub>ave</sub>) (sum), were also found to be 50.13 ± 3.79 Bq.kg<sup>-1</sup>, 0.136 ± 0.010, and 0.238 ± 0.089 mSvy<sup>-1</sup>, respectively. When the obtained results for all of the samples were compared to globally accepted criteria, they were discovered to be lower than the allowable world average levels. Furthermore, the lifetime cancer risk was revealed to be far lower than the allowable limit. According to the study, the risk of absorbing natural radionuclides from moringa leaf ingestion is insignificant. The findings can be utilized to create radiation safety norms and regulations for the use of moringa leaves as food and medication.</p>
Measurements of Natural Radioactivity and Radiological Hazards Assessment in Some Commercial Ceramic Tiles used in Ethiopia.
<p>Ceramic tile is a widely used decorative building material. The natural radionuclideconcentration ( 226 Ra, 232 Th, and 40 K) of ceramic wall and floor tiles typically used in Ethiopia was determined using an HPG detector. The study&#39;s goals are to determine the activity concentration of ceramic tiles as well as evaluate their health-related effects. The average activity concentrations of 226 Ra, 232 Th, and 40 K were 68.06 ± 2.07 Bq kg -1 , 131.19 ± 3.82 Bq kg -1 , and 802.04 ± 23.41 Bq kg -1 , respectively, which was found to be greater than the global mean. The calculated average value of Raeq was &lt; 370 Bq kg -1 , which is the limiting dose recommended for bulk medium. In addition, the related radiological hazard metrics, such as absorbed dose, annual effective dose equivalent, excess lifetime cancer risk (ELCR), internal (H in ) and external (H ex ) hazard indexes, gamma index (I γ ), and alpha index (I α ), were determined. The findings were contrasted with regional, global,and national legal frameworks as well as other similar studies&#39; findings. According to the results, using the examined ceramic tiles in buildings does not significantly increase radiation exposure.</p>
Open Dataset for publication: Half-life determination of 215At and 221Ra with high-purity radioactive ion beams - IS637
<p>This material is provided as a supplementary open data for the publication in preparation "Half-life determination of <sup>215</sup>At and <sup>221</sup>Ra with high-purity radioactive ion beams" and contains all the source files regarding this publication and determination of <sup>215</sup>At half-life. The data were collected in July and November 2018 during IS637 experiment at ISOLDE, CERN.</p>
Open Dataset for publication: Half-life determination of 215At and 221Ra with high-purity radioactive ion beams - IS665
<p>The dataset for publication in preparation:</p> <p>Half-life determination of <sup>215</sup>At and <sup>221</sup>Ra with high-purity radioactive ion beams</p> <p> </p> <p>Includes the data analysed for results given in the publication from the IS665 experimental campaign at ISOLDE (CERN).</p>
Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244
ClinicalTrials.gov study NCT00970359. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intrapatient Comparison of Urinary Radioactivity Following Piflufolastat (18F) and Flotufolastat (18F) PET in Men With Low PSA Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy
ClinicalTrials.gov study NCT06604442. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of PET Scans With the Radioactive Tracer 18F-BMS-986229 in Patients With Esophageal, Stomach, or Gastroesophageal Junction Cancer
ClinicalTrials.gov study NCT04161781. IPD Sharing: YES. Countries: 1. Publications: 1.
Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer
ClinicalTrials.gov study NCT02143726. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine
ClinicalTrials.gov study NCT00559949. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Radioactive Holmium Microspheres for the Treatment of Liver Metastases
ClinicalTrials.gov study NCT01031784. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Trial to Learn How a New Liquid Form of BAY1817080 is Tolerated and Taken up by the Body of Healthy Male Participants (Part A). By Labeling BAY1817080 With a Radioactive Substance (Carbon 14) Resear
ClinicalTrials.gov study NCT04487431. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.