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103 results for “randomised clinical trial”
HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho
<p>These are pseudo-anonymised data from the HOSENG randomized trial: " HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho". The data dictionary explains the data available in the dataset. Between July 2018 and December 2018, 10516 eligible individuals from 106 consenting villages were enrolled from two districts of Lesotho, and followed up for a maximum of 120 days. Main manuscript reference, DOI: <a href="https://doi.org/10.1016/s2352-3018(20)30233-2">10.1016/S2352-3018(20)30233-2. </a>The protocol was published, DOI:10.1186/s13063-019-3469-2.</p>
Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial
<p>These are pseudo-anonymised data from the VIBRA randomized trial: "Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomised clinical trial". The data dictionary explains the data available in the dataset. Between August 2018 and May 2019, 257 eligible individuals from 117 consenting villages were enrolled from two districts of Lesotho, and followed up for a maximum of 15 months. The protocol was published, doi: 10.1186/s13063-019-3510-5</p>
Dataset Treatment of early childhood caries with three different topical fluoride treatments: a randomised clinical trial
<p>These files contain the data and the research script about the effectiveness of the 38% silver diamine fluoride (SDF, SDI Riva Star) and Tiefenfluorid (TF, Humanchemie GmbH), using two different application protocols in children ≤71 months of age with early childhood caries, with a focus on patient-centred outcomes including major complications (pain, abscess, extraction) and minor complications (lesion progression).</p> <p>This work was funded by European Regional Development Fund Postdoc Latvia 1.1.1.2/VIAA/3/19/543, Contract No 9.-14.5/27. Uribe was supported by European Union’s Horizon 2020 grant agreement 857287 for the Baltic Biomaterials Centre of Excellence.</p>
Raw data related to: Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
<p><strong>Abstract</strong></p> <p>Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the e ective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
The effects of primary or secondary prevention with vitamin A supplementation on clinically important outcomes. A systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
<p>Meta data for the review entitled "The effects of primary or secondary prevention with vitamin A supplementation on clinically important outcomes. A systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis<strong>"</strong></p>
Training, executive, attention and motor skills (TEAMS) training versus standard treatment for preschool children with attention deficit hyperactivity disorder: a randomised clinical trial
<p>This is the dataset used in the trial entitled Training, executive, attention and motor skills (TEAMS) training versus standard treatment for preschool children with attention deficit hyperactivity disorder, published in BMC Research Notes.</p>
Comparative Study of Intravenous Esmolol & Magnesium Sulphate in Attenuating Hemodynamic Response during Laryngoscopy & Endotracheal Intubation in Patients Undergoing Valvular Heart Surgery: a Randomised Clinical Trial
<p>The present study aimed to compare the effectiveness of esmolol & magnesium sulphate in attenuating the hemodynamic response<br> to endotracheal intubation and to note any signifi cant side effects caused by these drugs.<br> Background: Induction with endotracheal intubation in patients undergoing valvular heart replacement pose lot of hemodynamic<br> variations. Obtunding hemodynamic response which can be deleterious in such patients pose a challenge to the cardiac anaesthetist. We<br> hypothesized that using esmolol as compared to magnesium sulphate will attenuate the hemodynamic response during laryngoscopy &<br> endotracheal intubation in patients undergoing valvular heart replacement.<br> Methods: This was a double blind, randomised, single centre, interventional, prospective study. In this study 96 patients were divided<br> into two groups with 48 patients each (n = 48) by sealed enveloped method of randomisation. Group E received esmolol 1.5 mg/ kg i.v<br> and Group M received magnesium sulphate 50 mg/ kg i.v each diluted in normal saline to make up a volume of 50 ml & given via infusion<br> slowly over 5 minutes by a burette set. Hemodynamic parameters like Heart Rate (HR), Mean Arterial Pressure (MAP), Systolic Blood<br> Pressure (SBP), Diastolic Blood Pressure (DBP) at baseline, 5 minutes after premedication, just before intubation 3, 5, 10 & 15 minutes<br> post intubation were recorded. The last observation at the end of 15 minutes post intubation was considered as the end of study.<br> Results: All the enrolled patients were analyzed. The esmolol group showed a decrease in the H.R from baseline (86.13 ± 15.87)<br> as compared to magnesium sulphate (98.51 ± 16.81 with a 95% CI, 4.62-4.69, p value < 0.001) 5 minute after premedication. There was<br> statistically signifi cant difference in H.R between both groups 5 minutes after drug administration.<br> Conclusion: Administration of esmolol before intubation in valvular heart patients undergoing valve replacement surgery controls the<br> hemodynamic response much better as compared to magnesium sulphate.</p>
Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial
<p>Datasets and analysis from A multi-centre, randomized controlled trial, on pediatric Atopic Dermatitis, conducted at Red Cross and Walter Sisulu Hospitals. The study is entitled Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial.</p>
A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide
ClinicalTrials.gov study NCT00696657. IPD Sharing: Not stated. Countries: 14. Publications: 1.
Hypnotherapy for Prevention of Relapse in Ulcerative Colitis: a Randomised, Single-blind, Controlled Clinical Trial
ClinicalTrials.gov study NCT00553163. IPD Sharing: NO. Countries: 1. Publications: 38.
Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicenter, assessor-blinded, cluster-randomised clinical trial
Open the record for dataset details and reuse information.
Direct pulp capping versus pulpotomy with MTA for carious primary molars: a 3-year randomised clinical trial
<p>Dataset for the analyses of the trial.</p>
Radix Sophorae flavescentis for chronic hepatitis B - Characteristics of potential randomised clinical trials
<p>This table listed the references considered to be potential randomised clinical trials on Radix Sophorae flavescentis for chronic hepatitis B, as we could not attain any response from the authors about their randomisation method. We also listed the results of contacting authors. </p> <p> </p>
A Comparison of Kneipp Hydrotherapy With Conventional Physiotherapy in the Treatment of Osteoarthritis of the Hip or Knee: Protocol of a Prospective Randomised Controlled Clinical Trial
ClinicalTrials.gov study NCT00950326. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial
ClinicalTrials.gov study NCT06121934. IPD Sharing: YES. Countries: 1. Publications: 4.
Efficacy of Combination of Hdroxyurea and Thalidomide Over Either Hydroxyurea or Thalidomide Alone in the Treatment of Transfusion Dependent Thalassemia in Children: A Quasi-Randomised Clinical Trial
ClinicalTrials.gov study NCT06299670. IPD Sharing: NO. Countries: 1. Publications: 22.
CHALLENGE. A Randomised Clinical Trial Examining Virtual Reality Therapy
ClinicalTrials.gov study NCT04661163. IPD Sharing: NO. Countries: 1. Publications: 1.
Manual Therapy of Spine With Postural Correction Exercise Compared With Conventional Therapy in Patients With Adhesive Capsulitis - A Randomised Clinical Trial
ClinicalTrials.gov study NCT06449261. IPD Sharing: NO. Countries: 1. Publications: 0.
Selective Axillary Lymph Node Dissection Vs Complete Axillary Dissection: A Randomised Clinical Trial to Assess the Prevention of Lymphedema in Breast Cancer Treatment
ClinicalTrials.gov study NCT03083314. IPD Sharing: NO. Countries: 1. Publications: 7.
Tong-Luo-Qu-Tong Plaster for KOA: a Randomised, Double-blind, Parallel Positive Control, Multi-center Clinical Trial
ClinicalTrials.gov study NCT03309501. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.