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Dataset results
16 results for “recombination suppression”
Widespread recombination suppression facilitates plant sex chromosome evolution
<p>Classical models suggest that recombination rates on sex chromosomes evolve in a stepwise manner to localize sexually antagonistic variants in the sex in which they are beneficial, thereby lowering rates of recombination between X and Y chromosomes. However, it is also possible that sex chromosome formation occurs in regions with pre-existing recombination suppression. To evaluate these possibilities, we constructed linkage maps and a chromosome-scale genome assembly for the dioecious plant <i>Rumex hastatulus</i>. This species has a polymorphic karyotype with a young neo-sex chromosome, resulting from a Robertsonian fusion between the X chromosome and an autosome, in part of its geographical range. We identified the shared and neo-sex chromosome using comparative genetic maps of the two cytotypes. We found that sex-linked regions of both the ancestral and the neo-sex chromosome are embedded in large regions of low recombination. Furthermore, our comparison of the recombination landscape of the neo-sex chromosome to its autosomal homologue indicates that low recombination rates preceded sex linkage. These patterns are not unique to the sex chromosomes; all chromosomes were characterized by massive regions of suppressed recombination spanning most of each chromosome. This represents an extreme case of the periphery-biased recombination seen in other systems with large chromosomes. Across all chromosomes, gene and repetitive sequence density correlated with recombination rate, with patterns of variation differing between repetitive element type. Our findings suggest that ancestrally low rates of recombination may facilitate the formation and subsequent evolution of heteromorphic sex chromosomes.</p>
Heterogeneous histories of recombination suppression on stickleback sex chromosomes
<p>How consistent are the evolutionary trajectories of sex chromosomes shortly after they form? Insights into the evolution of recombination, differentiation, and degeneration can be provided by comparing closely related species with homologous sex chromosomes. The sex chromosomes of the threespine stickleback (<em>Gasterosteus aculeatus</em>) and its sister species, the Japan Sea stickleback (<em>G. nipponicus)</em>, have been well characterized. Little is known, however, about the sex chromosomes of their congener, the blackspotted stickleback (<em>G. wheatlandi</em>). We used pedigrees to obtain experimentally phased whole genome sequences from blackspotted stickleback X and Y chromosomes. Using multispecies gene trees and analysis of shared duplications, we demonstrate that Chromosome 19 is the ancestral sex chromosome and that its oldest stratum evolved in the common ancestor of the genus. After the blackspotted lineage diverged, its sex chromosomes experienced independent and more extensive recombination suppression, greater X-Y differentiation, and a much higher rate of Y degeneration than the other two species. These patterns may result from a smaller effective population size in the blackspotted stickleback. A recent fusion between the ancestral blackspotted stickleback Y chromosome and Chromosome 12, which produced a neo-X and neo-Y, may have been favored by the very small size of the recombining region on the ancestral sex chromosome. We identify six strata on the ancestral and neo-sex chromosomes where recombination between the X and Y ceased at different times. These results confirm that sex chromosomes can evolve large differences within and between species over short evolutionary timescales.</p>
Data from: Repeated loss of function at HD mating-type genes and of recombination suppression without mating-type locus linkage in anther-smut fungi
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Heterogeneous histories of recombination suppression on stickleback sex chromosomes
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Widespread recombination suppression facilitates plant sex chromosome evolution
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Data from: Evidence of the accumulation of allele-specific non-synonymous substitutions in the young region of recombination suppression within the mating-type chromosomes of Neurospora tetrasperma
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DNA cytosine methylation suppresses meiotic recombination at the sex-determining region (RNA-Seq)
GEO Series GSE245612. Chlamydomonas reinhardtii. 8 samples. Type: Expression profiling by high throughput sequencing.
mTOR inhibitors suppress homologous recombination repair and synergize with PARP inhibitors via regulating SUV39H1 in BRCA-proficient triple-negative breast cancer
GEO Series GSE73923. Homo sapiens. 12 samples. Type: Expression profiling by array.
Data from: Impact of deleterious mutations, sexually antagonistic selection and mode of recombination suppression on transitions between male and female heterogamety.
Deleterious mutations accumulating on non-recombining Y chromosomes can drive XY to XY turnovers, as they allow to replace the old mutation-loaded Y by a new mutation-free one. The same process is thought to prevent XY to ZW turnovers, because the latter requires fixation of the ancestral Y, assuming dominance of the emergent feminizing mutation. Using individual-based simulations, we explored whether and how an epistatically dominant W allele can spread in a young XY system that gradually accumulates deleterious mutations. We also investigated how sexually antagonistic (SA) polymorphism on the ancestral sex chromosomes and the mechanism controlling X-Y recombination suppression affect these transitions. In contrast with XY to XY turnovers, XY to ZW turnovers cannot be favored by Y chromosome mutation load. If the arrest of X-Y recombination depends on genotypic sex, transitions are strongly hindered by deleterious mutations, and totally suppressed by very small SA cost, because deleterious mutations and female-detrimental SA alleles would have to fix with the Y. If, however, the arrest of X-Y recombination depends on phenotypic sex, X and Y recombine in XY ZW females, allowing for the purge of Y-linked deleterious mutations and loss of the SA polymorphism, causing XY to ZW turnovers to occur at the same rate as in the absence of deleterious and sex-antagonistic mutations. We generalize our results to other types of turnovers (e.g., triggered by non-dominant sex-determining mutations) and discuss their empirical relevance.
Data from: Impact of deleterious mutations, sexually antagonistic selection and mode of recombination suppression on transitions between male and female heterogamety.
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Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination
GEO Series GSE201210. Mus musculus. 24 samples. Type: Other.
DNA cytosine methylation suppresses meiotic recombination at the sex-determining region (Bisulfite-Seq)
GEO Series GSE245613. Chlamydomonas reinhardtii. 6 samples. Type: Methylation profiling by high throughput sequencing.
DNA cytosine methylation suppresses meiotic recombination at the sex-determining region (ChiP-Seq)
GEO Series GSE245611. Chlamydomonas reinhardtii. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DNA cytosine methylation suppresses meiotic recombination at the sex-determining region
GEO Series GSE245614. Chlamydomonas reinhardtii. 42 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Recombination suppression on fungal mating-type chromosomes without mating-type loci linkage and with loss of function of HD mating-type genes
GEO Series GSE233508. Microbotryum violaceum. 21 samples. Type: Expression profiling by high throughput sequencing.
DNA cytosine methylation suppresses meiotic recombination at the sex-determining region (H3K27ac ChIP-seq)
GEO Series GSE267292. Chlamydomonas reinhardtii. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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