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ShareScore release 0.9.0
Dataset results
16 results for “regulation and transmission”
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
<p><span>The perforant path provides the primary cortical excitatory input to the hippocampus. Due to its important role in information processing and coding, entorhinal projections to the dentate gyrus have been studied in considerable detail. Nevertheless, synaptic transmission between individual connected pairs of entorhinal </span><span>stellate cells and dentate granule cells</span><span> remains to be characterized. Here, we have used mouse organotypic entorhino-hippocampal tissue cultures of either sex, in which the entorhino-dentate (EC-GC) projection is present and EC-GC pairs can be studied using whole-cell patch clamp recordings. By using cultures of wildtype mice, the properties of EC-GC synapses formed by afferents from the lateral and medial entorhinal cortex were compared and differences in short-term plasticity were identified. Since the perforant path is severely affected in Alzheimer´s disease, we used tissue cultures of amyloid-precursor protein (APP)-deficient mice to examine the role of APP at this synapse. APP deficiency altered excitatory neurotransmission at medial perforant path synapses, which was accompanied by transcriptomic and ultrastructural changes. Moreover, presynaptic but not postsynaptic APP deletion through the local injection of Cre-expressing adeno-associated viruses in conditional APP<sup>flox/flox</sup> tissue cultures increased the neurotransmission efficacy at perforant path synapses. In summary, these data suggest a physiological role for presynaptic APP at medial perforant path synapses that may be adversely affected under altered APP processing conditions.</span></p>
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
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Datasets for "GABAergic miR-34a regulates Dorsal Raphè inhibitory transmission in response to aversive, but not rewarding, stimuli"
<p>Datasets for "GABAergic miR-34a regulates Dorsal Raphè inhibitory transmission in response to aversive, but not rewarding, stimuli"</p>
A scaffold attachment factor PHM-2 regulates synaptic transmission through SLO-2 potassium channel in C. elegans
GEO Series GSE315272. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility
GEO Series GSE151742. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing; Other.
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance [RNA-seq]
GEO Series GSE294801. Mycobacterium tuberculosis. 535 samples. Type: Expression profiling by high throughput sequencing.
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
GEO Series GSE304457. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum
GEO Series GSE99223. Plasmodium falciparum. 12 samples. Type: Expression profiling by array.
Regulation of Puf2 Expression is Critical for Plasmodium Sporozoite Development and Maintenance of Sporozoite Transmissibility
GEO Series GSE41873. Plasmodium yoelii yoelii 17XNL. 2 samples. Type: Expression profiling by high throughput sequencing.
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance [IDAP-seq]
GEO Series GSE294802. Mycobacterium tuberculosis. 4 samples. Type: Other.
Data from: Social structure contains epidemics and regulates individual roles in disease transmission in a group-living mammal
Population structure is critical to infectious disease transmission. As a result, theoretical and empirical contact networks models of infectious disease spread are increasingly providing valuable insights into wildlife epidemiology. Analysing an exceptionally detailed data set on contact structure within a high-density population of European badgers Meles meles, we show that a modular contact network produced by spatially structured stable social groups, lead to smaller epidemics, particularly for infections with intermediate transmissibility. The key advance is that we identify considerable variation among individuals in their role in disease spread, with these new insights made possible by the detail in the badger data set. Furthermore, the important impacts on epidemiology are found even though the modularity of the badger network is much lower than the threshold that previous work suggested was necessary. These findings reveal the importance of stable social group structure for disease dynamics with important management implications for socially-structured populations.
Data from: Social structure contains epidemics and regulates individual roles in disease transmission in a group-living mammal
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Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei
GEO Series GSE81765. Trypanosoma brucei. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
GEO Series GSE213284. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
A seven-helix protein acts as a key regulator of translation during human-to-mosquito transmission of Plasmodium falciparum
GEO Series GSE103012. Plasmodium falciparum. 2 samples. Type: Expression profiling by array.
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
GEO Series GSE131428. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.