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381 results for “relational model”
Data from systematic audit for paper: Insights into the quantification and reporting of model-related uncertainty across different disciplines
<p>This upload contains 7 data files (each contains cleaned and compiled data for a given scientific field) and 2 R scripts. These files support the paper: Insights into the quantification and reporting of model-related uncertainty across different disciplines.</p> <p> </p> <p><strong>Description of the data</strong></p> <p>Compiled data files for each field contain all reviewers audit answers for eligible papers. All papers that met exclusion criteria have been removed.</p> <p>Data checks have been performed and formatting errors corrected either in R or manually, following steps detailed in the STAR methods.</p> <p>Column names and description:</p> <ul> <li>Number: number of question from 1 to 9</li> <li>Questions: question text – question to be answered by the reviewer</li> <li>QuestionCode: shortened code for each question</li> <li>Paper: paper code - first author surname/initial and surname and year</li> <li>Initials: initials of reviewer</li> <li>Answer: answer to the question</li> <li>Details: extra details to support the answer</li> <li>Location: where in the text the uncertainty was presented</li> <li>Presentation: how the uncertainty was presented</li> <li>ModelType: type of model (focal model)</li> <li>Comments: any other comments from the reviewer</li> <li>Checks: checks of whether NA or no have been included in correct places e.g. if answers to questions 1:4 are no then question 9 is NA, if question 7 is no then 8 is NA</li> <li>Check 1 = when Answer = No, Location is NA</li> <li>Check 2 = when Answer to Number 1-4, 6 or 8-9 is Yes that Details are not NA</li> <li>Check 3 = when Answer = No, Presentation = NA</li> <li>Check 4 = when Location is not NA, presentation is not NA</li> <li>Check 5 = if the Answer to 5 or 7 is "No" then Answer to 6 and 8 = "NA"</li> <li>Check 6 = if Answer for 1-4 is "No", then Answer for 9 = "NA"</li> </ul> <p><strong>Code description</strong></p> <p>Two scripts are included, the first is theme_script.R, this includes code to set up a ggplot theme for the figures. The second is Figure_code.R, this script contains all code to plot and save the three figures from the paper.</p>
Research data related to switchable contact model (SCM) development
<p>Research data of the linked journal article, is composed of input and output files of the LIGGGHTS simulations (Project folders) and an Excel data sheet (Results_Excel) which includes calculated data.</p> <p>The contents are the simulation data and results of cake formation in centrifugal filtration using conventional (mesh) method and novel Switchable contact model (SCM, primitive) method. (For more information see the linked article and the source code of SCM: <a href="https://github.com/DamlaSerper/SCM">https://github.com/DamlaSerper/SCM</a>)</p>
Modelled relative abundance of bird species in Britain and Ireland 2007-2011
<p>This data package describes the modelled relative (not absolute) abundance of Carrion Crow (<em>Corvus corone</em>), Magpie (<em>Pica pica</em>), Buzzard (<em>Buteo buteo</em>), Kestrel (<em>Falco tinnunculus</em>) and Red Kite (<em>Milvus milvus</em>) in Britain and Ireland.</p> <p>This was used to produce Bird Atlas 2007-2011 <a href="https://app.bto.org/mapstore/StoreServlet" target="_blank" rel="noopener">maps</a> of relative abundance at a tetrad (2x2km) resolution. </p> <p>Acknowledgement: These data originate from the Bird Atlas 2007–11 project which was run by the BTO in partnership with BirdWatch Ireland and the Scottish Ornithologists’ Club. We are grateful to the thousands of volunteers who undertook and organised the fieldwork for the atlas.</p> <p>Please refer to the metadata for a more detailed description, and for information on dataset usage.</p> <p>v1.3 update: added Red Kite (<em>Milvus milvus</em>) and put the species lookup back in.</p> <p><em>If you would like access to this data for another species, please get in touch with BTO via email: datarequests@bto.org</em></p> <p>........................................................................................</p> <p>BTO would also greatly appreciate if you could fill out <a href="https://forms.gle/DCc58VXpdmqnTmTk8" target="_blank" rel="noopener">this very short form</a> to tell us how you intend to use these data. Thanks in advance!</p>
Data related to Süsser et al. (2021) QTDIAN modelling toolbox
<p>QTDIAN - Quantification of Technological DIffusion and sociAl constraiNts - is a toolbox of qualitative and quantitative descriptions of socio-technical and political aspects of the energy transition that influence the overall potential, the rate of energy-related technology and service diffusion and the design of the future energy system. The output of QTIDIAN is empirically founded datasets of social and political drivers and barriers of the transition, both in the form of raw data describing past and current developments and manipulated to constitute consistent quantifications of the storylines. Here you can download the data for six QTDIAN themes:</p> <ul> <li>Socially feasible scaling of energy technologies</li> <li>Policy preferences & dynamics</li> <li>Barriers to infrastructural development (wind energy, grid development)</li> <li>Citizen energy</li> <li>Private energy demand</li> </ul> <p>Further information on the QTDIAN modelling toolbox and the data can be found in the SENTINEL Deliverable 2.3 and Deliverable 2.4:</p> <p><a href="https://www.iass-potsdam.de/de/ergebnisse/publikationen/2021/qtdian-modelling-toolbox-quantification-social-drivers-and">Süsser, D., al Rakouki, H., & Lilliestam, J.(2021). The QTDIAN modelling toolbox–Quantification of social drivers and constraints of the diffusion of energy technologies. Deliverable 2.3. Sustainable Energy Transitions Laboratory (SENTINEL) project. Potsdam: Institute for Advanced Sustainability Studies (IASS).</a></p> <p><a href="https://www.iass-potsdam.de/de/ergebnisse/publikationen/2021/integration-socio-technological-transition-constraints-energy-demand">Süsser, D., Pickering, B., Chatterjee, S., Oreggioni, G., Stavrakas, V., & Lilliestam, J.(2021). Integration of socio-technological transition constraints into energy demand and systems models. Deliverable 2.5. Sustainable Energy Transitions Laboratory (SENTINEL) project. Potsdam: Institute for Advanced Sustainability Studies (IASS).</a></p>
dataset related to article "Seizure activity and brain damage in a model of focal non-convulsive status epilepticus"
<p>Excell files with the values used on the construction of the graphical illustrations for the publication</p>
A multiple model high-resolution head-related impulse response database for aided and unaided ears (HDF5 format)
<p>The Multiple-Model High Resolution HRTF database is a collection of HRTFs measured using four different Head-and-Torso Simulators at high spatial resolution (2 degree azimuth and elevation). The data here is stored in HDF5 files, the SOFA files are published in a separate dataset <a href="https://zenodo.org/record/2582553">doi:10.5281/zenodo.2582553</a>.</p>
Dataset related to article "New in silico models to predict in vitro micronucleus induction as marker of genotoxicity"
<p>The .txt file contains the dataset of the in silico model for genotoxicity as induction of micronuclei.</p> <p>The .doc file contains the descriptors of the models and the structural alerts.</p>
InSAR interferences and slip model related to the 2021 Maduo earthquake in Qinghai province, China
<p>The dataset includes the SAR unwrapped interferograms, and the slip model related to the 2021 Maduo earthquake on western Maduo County, Qinghai Province of China.</p> <p>SAR images:</p> <p>Sensor: Sentinel-1 A/B ascending and descending tracks interferograms, including the T099A, T026A, T172A, T106D, T004D and T033D.</p> <p>Time: 2021.05.13 - 2019.05.27, 6 radar phases images and 2 range offset images.</p> <p>Processing software: GAMMA</p> <p>Topographic data from the Shuttle Radar Topography Mission (SRTM) with a resolution of 1 arcsec were used to align the images and remove the topographic phase.</p> <p>First‐order tropospheric delays were mitigated by using the Generic Atmospheric Correction Online Service (GACOS)</p> <p>Silp Models:</p> <p>The model is generated through triangular dislocation inversion.</p> <p>The slip models is composed of two files:</p> <p> Main rupture: Slip_Maduo_Main.gmt</p> <p> Tip rupture: Slip_Maduo_Tip.gmt</p> <p>Format: GMT</p>
Glycosylated models for: The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2
<p>Glycosylated models (as PDB files) of the sarbecovirus spike proteins used in the study: The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2.</p>
Bern3D model output related to: Hysteresis of the Earth system under positive and negative CO2 emissions
<p>The data below is output from the Bern3D intermediate complexity model and idealized CO2 increase-decrease simulations used in Jeltsch-Thömmes et al., Environ. Res. Lett. 15 (2020) 124026, https://doi.org/10.1088/1748-9326/abc4af</p> <p><br> The data are provided as .csv and .nc files<br> There are different types of data</p> <p><br> 1) TIMESERIES DATA (Fig. 1 and 2)<br> =================================<br> The name of the files indicates the variable:<br> co2_ts.csv change in atm. co2 [ppm]<br> cumulativeEmissions_ts.csv cumulative emissions [GtC]<br> cumulativeAOflux_ts.csv cumulative atm-ocean C flux [GtC]<br> cumulativeABflux_ts.csv cumulative atm-land C flux [GtC]<br> sat_ts.csv change in surface air temperature [degC]<br> ohc_ts.csv change in ocean heat content [10^24 J]<br> amoc_ts.csv change in Atlantic meridional overturning circulation strength [Sv]<br> seaice_ts.csv fraction of pre-industrial sea-ice area remaining [fraction of PI]<br> <br> The first row in the .csv files contains the header, which indicates the experiment. The naming convention is as follows:<br> c4k#_###</p> <p>c4 indicates the maximum co2 as times pre-industrial (4 times)<br> k# indicates the equilibrium climate sensitivity of the respective simulation in degrees C (k2 to k5)<br> ### indicates the rate of CDR:<br> 010: 0.1% yr^-1<br> 010: 0.3% yr^-1<br> 010: 0.5% yr^-1<br> 010: 0.7% yr^-1<br> 100: 1% yr^-1<br> 200: 2% yr^-1<br> 400: 4% yr^-1<br> 600: 6% yr^-1</p> <p><br> 2) HYSTERESIS DATA (Fig. 3)<br> ===========================<br> The name of the files indicates the variables:<br> cumulativeEmissions_sat.csv cumulative emissions and change in surface air temperature [degC]<br> cumulativeEmissions_OHCsurf.csv cumulative emissions and change in upper ocean heat content (0-700 m) [10^24 J]<br> cumulativeEmissions_o2thermo.csv cumulative emissions and change in thermocline (200-600 m) o2 [mmol m^-3]<br> cumulativeEmissions_OM_arag.csv cumulative emissions and fraction of water in the uppermost 175 m with omegar_aragonite saturation state >3 [fraction]</p> <p>each file contains the time (simulation year) as well as cumulative emissions (cumuEmis) and the respective variable (same naming as in filename) for all the experiments (see timeseries data for naming convention)</p> <p><br> 3) SPATIAL DATA (Fig. 4 and 5)<br> ==============================<br> All data for Fig. 4 and 5 are contained in one single .nc file (fig4_5_data.nc) with a varibale for each map shown in Fig. 4 and 5:<br> c4k2_100_sat hysteresis (down-path minus up-path) in surface air temperature at cumulative emissions of 1000 GtC, ECS=2 degC, in [degC]<br> c4k3_100_sat hysteresis (down-path minus up-path) in surface air temperature at cumulative emissions of 1000 GtC, ECS=3 degC, in [degC]<br> c4k5_100_sat hysteresis (down-path minus up-path) in surface air temperature at cumulative emissions of 1000 GtC, ECS=5 degC, in [degC]<br> <br> c4k2_100_o2thermo hysteresis (down-path minus up-path) in thermocline (200-600 m) o2 at cumulative emissions of 1000 GtC, ECS=2 degC, in [mmol m^-3]<br> c4k3_100_o2thermo hysteresis (down-path minus up-path) in thermocline (200-600 m) o2 at cumulative emissions of 1000 GtC, ECS=3 degC, in [mmol m^-3]<br> c4k5_100_o2thermo hysteresis (down-path minus up-path) in thermocline (200-600 m) o2 at cumulative emissions of 1000 GtC, ECS=5 degC, in [mmol m^-3]<br> <br> c4k3_100_Om_arag_up mean aragonite saturation state of the uppermost 175 m at cumulative emissions of 1000 GtC on the up-path, ECS=3 degC, [unitless]<br> c4k3_100_Om_arag_do mean aragonite saturation state of the uppermost 175 m at cumulative emissions of 1000 GtC on the down-path, ECS=3 degC, [unitless]</p> <p> </p> <p> </p> <p><br> The files can be readily importet in python, for example, by:<br> import pandas as pd<br> import xarray as xr<br> <br> # for the .csv files<br> df = pd.read_csv('path+filename', sep=',', header=0, index_col=None)<br> <br> # for the .nc files<br> ds = xr.open_dataset('path+filename')</p> <p><br> For additional information or in case of questions please contact:<br> Aurich Jeltsch-Thömmes<br> aurich.jeltsch-thoemmes@unibe.ch</p>
Data related to the manuscript "Bayesian Calibration and Validation of a Large-scale and Time-demanding Sediment Transport Model"
<p>1) Riverbed_Elevation_Measurements.txt<br> Description: Measured riverbed geometry of available years<br> Columns: Node ID, Easting [m], Northig [m], Elevation 2002 [m asl], Elevation 2005 [m asl], Elevation 2010 [m asl], Elevation <br> 2013 [m asl]<br> ----------------------------------------------------------------------------------------------------------------------------<br> 2) Hydro_FT_2D_manual.txt<br> Description: Simulation results of the manually calibrated full model<br> Columns: Node ID, Easting [m], Northig [m], Elevation 2005 [m asl], Elevation 2010 [m asl], Elevation 2013 [m asl]</p> <p>3.1) Hydro_FT_2D_CollocationPointBase.txt<br> Description: Parameter combinations of the collocation point base for each of the 20 simulations conducted with the full model to <br> construct the surrogate<br> Rows: Critical Shields parameter, Grain Roughness, Grain Size distribution</p> <p>3.2) Hydro_FT_2D_CollocationResults.txt<br> Description: Simulation results of the 20 simulations conducted with the full model at the collocation points<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2005 [m asl] of simulation 1 through 20, Node ID, Easting [m asl], Northig<br> [m asl], Elevations 2010 [m asl] of simulation 1 through 20, Node ID, Easting [m asl], Northig [m asl], Elevations 2013 [m asl] of<br> simulation 1 through 20<br> ----------------------------------------------------------------------------------------------------------------------------<br> 4.1) aPC_MC_N_Combinations_Weights_prior.txt<br> Description: ID of prior MC runs with tested parameter combinations and corresponding importance weights<br> Rows: ID of MC runs, Critical Shields parameter, Grain Roughness, Grain Size distribution, importance weights<br> 4.2) aPC_MC_2005_prior.txt<br> Description: aPC surrogate results of prior MC runs for 2005<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2005 [m asl] of MC run 1 through 100,000<br> 4.3) aPC_MC_2010_prior.txt<br> Description: aPC surrogate results of prior MC runs for 2010<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2010 [m asl] of MC run 1 through 100,000<br> 4.4) aPC_MC_2013_prior.txt<br> Description: aPC surrogate results of prior MC runs for 2013<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2013 [m asl] of MC run 1 through 100,000<br> <br> 4.5) aPC_MC_N_Combinations_Weights_posterior.txt<br> Description: ID of accepted (posterior) MC runs with tested parameter combinations and corresponding importance weights<br> Rows: ID of accepted MC runs, Critical Shields parameter, Grain Roughness, Grain Size distribution, importance weights<br> 4.6) aPC_MC_2005_posterior.txt<br> Description: aPC surrogate results of posterior MC runs for 2005<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2005 [m asl] of accepted MC run 1 through 857<br> 4.7) aPC_MC_2010_posterior.txt<br> Description: aPC surrogate results of posterior MC runs for 2010<br> Columns: Node ID, Easting [m], Northig [m], Elevations 2010 [m asl] of accepted MC run 1 through 857<br> 4.8) aPC_MC_2013_posterior.txt<br> Description: aPC surrogate results of posterior MC runs for 2013<br> Columns: Node ID, Easting [m], Northig [m], Elevation 2013 [m asl] of accepted MC run 1 through 857<br> ----------------------------------------------------------------------------------------------------------------------------<br> 5) aPC_MAP.txt<br> Description: Simulation results conducted with the stochastically calibrated aPC surrogate model using the MAP parameter <br> combination<br> Columns: Node ID, Easting [m], Northig [m], Elevation 2005 [m asl], Elevation 2010 [m asl], Elevation 2013 [m asl]</p> <p>6) Hydro_FT_2D_MAP.txt<br> Description: Simulation results conducted with the stochastically calibrated full model using the MAP parameter combination<br> Columns: Node ID, Easting [m], Northig [m], Elevation 2005 [m asl], Elevation 2010 [m asl], Elevation 2013 [m asl]<br> ----------------------------------------------------------------------------------------------------------------------------<br> 7) dz.txt<br> Description: Riverbed Evolution for all nodes in the section of interest (n=1138) obtained with differently calibrated models for all <br> considered time periods<br> Columns: Node ID, Easting [m asl], Northig [m asl], aPC_prior 2005 [m], aPC_posterior 2005 [m], aPC_MAP 2005 [m], <br> Hydro_FT-2D_MAP 2005 [m], Hydro_FT-2D_manual 2005 [m], aPC_prior 2010 [m], aPC_posterior 2010 [m], aPC_MAP 2010 [m],<br> Hydro_FT-2D_MAP 2010 [m], Hydro_FT-2D_manual 2010 [m], aPC_prior 2013 [m], aPC_posterior 2013 [m], aPC_MAP 2013 [m],<br> Hydro_FT-2D_MAP 2013 [m], Hydro_FT-2D_manual 2013 [m]</p> <p>8) dz_CalibrationNodes.txt<br> Description: Riverbed Evolution for calibration nodes (n=204) obtained with differently calibrated models for all considered time<br> periods<br> Columns: Node ID, Easting [m asl], Northig [m asl], aPC_prior 2005 [m], aPC_posterior 2005 [m], aPC_MAP 2005 [m], <br> Hydro_FT-2D_MAP 2005 [m], Hydro_FT-2D_manual 2005 [m], aPC_prior 2010 [m], aPC_posterior 2010 [m], aPC_MAP 2010 [m],<br> Hydro_FT-2D_MAP 2010 [m], Hydro_FT-2D_manual 2010 [m], aPC_prior 2013 [m], aPC_posterior 2013 [m], aPC_MAP 2013 [m],<br> Hydro_FT-2D_MAP 2013 [m], Hydro_FT-2D_manual 2013 [m]</p> <p> </p>
Data and code related to the article "Characterization of the Log-normal Model for Received Signal Strength Measurements in Real Wireless Sensor Networks"
<p>This upload contains the data and code related to the article "Characterization of the Log-normal Model for Received Signal Strength Measurements in Real Wireless Sensor Networks", (D.O.I: <a href="https://doi.org/10.3390/jsan9010012">10.3390/jsan9010012</a>) published in the the special issue on "Localization in Wireless Sensor Networks" of the <a href="https://www.mdpi.com/journal/jsan"><em>Journal of Sensor and Actuator Networks</em></a> (ISSN 2224-2708).</p> <p>The data and code included allows to replicate the results of the article.</p>
A multiple model high-resolution head-related impulse response database for aided and unaided ears (SOFA format)
<p>The Multiple-Model High Resolution HRTF database is a collection of HRTFs measured using four different Head-and-Torso Simulators at high spatial resolution (2 degree azimuth and elevation). The data here is stored in SOFA format, with the data identical to the HDF5 files in <a href="https://zenodo.org/record/1226873">doi:10.5281/zenodo.1226873</a>.</p>
Improving distribution models of sparsely-documented disease vectors by incorporating information on related species via joint modeling
<p>A necessary component of understanding vector-borne disease risk is the accurate characterization of the distributions of their vectors. Species distribution models have been successfully applied to data-rich species but may produce inaccurate results for sparsely-documented vectors. In light of global change, vectors that are currently not well-documented could become increasingly important, requiring tools to predict their distributions. One way to achieve this could be to leverage data on related species to inform the distribution of a<strong> </strong>sparsely-documented vector based on the assumption that the environmental niches of related species are not independent. Relatedly, there is a natural dependence of the spatial distribution of a disease on the spatial dependence of its vector. Here, we propose to exploit these correlations by fitting a hierarchical model jointly to data on multiple vector species and their associated human diseases to improve distribution models of sparsely-documented species. To demonstrate this approach, we evaluated the ability of twelve models—which differed in their pooling of data from multiple vector species and inclusion of disease data—to improve distribution estimates of sparsely-documented vectors. We assessed our models on two simulated data sets, which allowed us to generalize our results and examine their mechanisms. We found that when the focal species is sparsely documented, incorporating data on related vector species reduces uncertainty and improves accuracy by reducing overfitting. When data on vector species are already incorporated, disease data only marginally improve model performance. However, when data on other vectors are not available, disease data can improve model accuracy and reduce overfitting and uncertainty. We then assessed the approach on empirical data on ticks and tick-borne diseases in Florida and found that incorporating data on other vector species improved model performance. This study illustrates the value of exploiting correlated data via joint modeling to improve distribution models of data-limited species.</p>
Datasets related to the study "Spatial variability and future evolution of surface solar radiation over Northern France and Benelux: a regional climate model approach"
<p>This dataset contains the data of the manuscript "Spatial variability and future evolution of surface solar radiation over Northern France and Benelux: a regional climate model approach" under publication in Atmospheric Chemistry and Physics. <br>It includes CNRM-ALADIN64 simulations of surface solar radiation, cloud fraction, aerosol optical depth and water vapor content. <br>A directory is dedicated to HINDCAST simulations. It includes all datasets involved in the evaluation of CNRM-ALADIN64 simulations, as well as all datasets used for the analysis of the spatial variability of surface solar irradiance over the recent past. <br>Another directory is dedicated to future climate simulations. In this case, several sub directories can be found, representing either the simulations over the historical period (2005-2014, i.e. HIST directory), or simulations at mid (2045-2054, "mid" suffix) and long term (2091-2100, "end" suffix) horizons for SSP1-1.9 and SSP3-7.0. Each set of climate simulations is composed of three members (r1f, r2f, r3f), which were used collectively to increase the statistical significance of our analysis. </p>
Data and codes related to the article: Renard et al. A Hidden Climate Indices Modeling Framework for Multi-Variable Space-Time Data. Water Resources Research.
<p>This package contains data and codes related to the article:</p> <p>B. Renard, M. Thyer, D. McInerney, D. Kavetski, M. Leonard and S. Westra. A Hidden Climate Indices Modeling Framework for Multi-Variable Space-Time Data. <em>Water Resources Research</em>.</p> <p><strong>R scripts</strong></p> <p>The main computations of the paper have been performed using a computing code named <a href="https://github.com/STooDs-tools">STooDs</a>, which is called using the bash script launchpad.sh.</p> <p>The R scripts in this package only perform pre-processing (create configuration files) and post-processing (analyze results) steps.</p> <ul> <li>Funk.R: a set of functions called by other scripts.</li> <li>1_defineModel.R: define the model to be inferred and create STooDs configuration files in <em>dataset_XXX/runs.</em></li> <li>2_analyzeResults.R: analyze the outputs of STooDs runs.</li> <li>3_crossValidation.R: analyze the outputs of cross-validation experiments in <em>dataset_XV</em> and <em>dataset_XV_1971-1990</em>.</li> </ul> <p><strong>Data</strong></p> <p>Data for the 3 cases (full dataset and 2 cross-validation experiments) are located in folders <em>dataset_XXX/data</em>.</p> <ul> <li>dat.txt: raw dataset in text format.</li> <li>dataset.RData: dataset in RData format.</li> <li>DMI.txt, NINO.txt, SAM.txt: 3 standard climate indices.</li> <li>spaceP.txt, spaceQ.txt, spaceT.txt: properties of Precipitation (P), Streamflow (Q) and Temperature (T) stations.</li> <li>[only for cross-validation experiments] validation.RData: left-out data used for validation.</li> </ul> <p> </p> <p> </p>
Dataset related to article "Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma"
<p>This record contains data related to article "Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma".</p> <p>Myxoid liposarcoma (MLPS) is a rare soft-tissue sarcoma characterised by the expression of FUS-DDIT3 chimera. Trabectedin has shown significant clinical anti-tumour activity against MLPS. To characterise the molecular mechanism of trabectedin sensitivity and of resistance against it, we integrated genomic and transcriptomic data from treated mice bearing ML017 or ML017/ET, two patient-derived MLPS xenograft models, sensitive to and resistant against trabectedin, respectively. Longitudinal RNA-Seq analysis of ML017 showed that trabectedin acts mainly as a transcriptional regulator: 15 days after the third dose trabectedin modulates the transcription of 4883 genes involved in processes that sustain adipocyte differentiation. No such differences were observed in ML017/ET. Genomic analysis showed that prolonged treatment causes losses in 4p15.2, 4p16.3 and 17q21.3 cytobands leading to acquired-resistance against the drug. The results dissect the complex mechanism of action of trabectedin and provide the basis for novel combinatorial approaches for the treatment of MLPS that could overcome drug-resistance.</p>
Dataset related to aticle "Additive Fabrication of a Vascular 3D Phantom for Stereotactic Radiosurgery of Arteriovenous Malformations"The database contains 3D models in STL file format of a patient-specific brain arteriovenous malformation phantom reconstructed from computed tomography scans.
<p><em>The database contains 3D models in STL file format of a patient-specific brain arteriovenous malformation phantom reconstructed from computed tomography scans.</em></p>
Labeled data and models for COVID-19 vaccine related tweets with stance, location, and topics
<p>The dataset contains Tweet IDs along with the location and tweet timestamp. The tweets are labeled based on motivating/demotivating status, stance towards the COVID-19 vaccine, and topic in the tweet text. To comply with Twitter guidelines, we removed the tweet texts and author information. You can use Hydrator API to hydrate the tweets.</p> <p>The repository also contains the machine-learning models for topic modeling, de/motivation classifier, and stance detection from the tweets.</p>
Data and code related to publication "Migration pulsedness alters patterns of allele fixation and local adaptation in a mainland-island model" - Aubree et al. 2021
<p>Those data sets and codes are related to the manuscript "Migration pulsedness alters patterns of allele fixation and local adaptation in a mainland-island model" available on BioRXiv.</p> <p>All the information that are necessary to use those data sets and codes are contained in the file "readme.txt".</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.