Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
34
datasets available to search
ShareScore release 0.7.1
Dataset results
34 results for “relaxed selection”
An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection: Dataset
<p>Supplementary files (data and analysis) for "An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection"</p> <p>Supplementary File 1: C3H_pheno_fix_Jun7_2023_nolowmut.csv</p> <p>Data for all mice in MA experiment including: mouse ID, sire, dam, generation, mating ID, sex, weight at 3 weeks, weight at 6 weeks, tail length, litter size, litter ID, line ID</p> <p> </p> <p>Supplementary File 2: C3H_pheno_Kontrol_June2023.csv</p> <p>Data for all control mice including: mouse ID, sire, dam, generation, mating ID, sex, weight at 3 weeks, weight at 6 weeks, tail length, litter size, litter ID, line ID</p> <p> </p> <p>Supplementary File 3: C3H_birthdates.csv</p> <p>Data for all C3H mice including: mouse ID, birthdate</p> <p> </p> <p>Supplementary File 4: MA_pheno.R</p> <p>R code for visualising trait data, running linear regressions, and comparing control and MA experiment data</p> <p> </p> <p>Supplementary File 5: C3H_pheno_burnin20_Jun7_2023_nolowmut.csv</p> <p>Data for all mice in MA experiment including a 20 generation burn-in to simulate mutation-drift balance for Animal model analyses: mouse ID, sire, dam, generation, mating ID, sex, weight at 3 weeks, weight at 6 weeks, tail length, litter size, litter ID, line ID</p> <p> </p> <p>Supplementary File 6: asreml_C3H_ALL.R</p> <p>R code for estimating mutational heritabilities using mixed model analysis</p> <p> </p> <p>Supplementary File 7: C3H_ped_rekey_Jun2023.csv</p> <p>Pedigree data for all mice in MA experiment</p> <p> </p> <p>Supplementary File 8: C3H_ped_rekey_KEY.csv</p> <p>Key for pedigree data file</p> <p> </p> <p>Supplementary File 9: plot_pedigree_tree_MS_final.R</p> <p>R code for visualising pedigree of mice in MA experiment</p>
Relaxation of purifying selection suggests low effective population size in eusocial Hymenoptera and solitary pollinating bees
<p>Data and results of the paper "Relaxation of purifying selection suggests low effective population size in eusocial Hymenoptera and solitary pollinating bees".</p> <p>- data_table_species.csv: contains life-history and geographical range descriptors, terminal branch length and genomic estimated values for each substitution category, for each species in the dataset. Contains results obtained with both the complete data set and the subsampled dataset with 88 species.</p> <p>- data_table_genes.csv: contains values of substitution count that are sums of the values obtained for every species in the alignment. Also contains the results of HyPhy RELAX analyses for each alignment.</p> <p>- data_table_genes_species.csv: contains estimated values for each substitution category for each species in each alignment. Contains results obtained with both the complete data set and the subsampled dataset with 88 species.</p> <p> </p>
Data from: Interplay of trophic relaxation and directional selection shapes eco-evolutionary responses to selective harvest in predator-prey systems
Open the record for dataset details and reuse information.
Mimicry in motion and morphology: do information limitation, trade-offs or compensation relax selection for mimetic accuracy?
<p>Many animals mimic dangerous or undesirable prey as a defence from predators. We would expect predators to reliably and exclusively avoid animals that closely resemble dangerous prey, yet imperfect mimics are common. There have been many hypotheses suggested to explain imperfect mimicry, but comparative tests across multiple mimicry systems are needed to determine which are applicable, and which—if any—represent general principles of imperfect mimicry. We tested four hypotheses on Australian ant mimics and found support for only one of them: the information limitation hypothesis. A predator with incomplete information will be unable to discriminate some poor mimics from their models. We also show that since predators must make decisions while they are learning, they are likely to never sample broadly enough to gain and utilise the full information needed to discriminate poor mimics from their models. We found no evidence that one accurate mimetic trait can compensate for another, or that rapid movement reduces selection pressure for good mimicry. Based on our results, we argue that information limitation is likely to be a general principle behind imperfect mimicry of any complex traits, while interactions between components of mimicry may apply to some mimicry systems but not others.</p>
Pervasive relaxed selection on spermatogenesis genes in gorillas coincident with the evolution of polygyny
<p>Gorillas have a polygynous social system in which the highest-ranking male has almost exclusive access to females and sires most of the offspring in the troop. Such behavior results in a dramatic reduction of sperm competition, which is ultimately associated with numerous traits leading to a low efficacy of gorilla spermatogenesis. However, the molecular basis behind the remarkable erosion of the gorilla male reproductive system remains unknown. Here, we explored the genetic consequences of the polygynous social system in gorillas by testing for altered selection intensity across 13,310 orthologous protein-coding genes from 261 Eutherian mammals. We identified 578 genes with relaxed purifying selection in the gorilla lineage, compared with only 96 that were positively selected. Genes under relaxed purifying selection in gorillas have accumulated numerous deleterious amino acid substitutions; their expression is biased towards male germ cells, and are enriched in functions related to meiosis and sperm biology. We tested the function of gorilla relaxed genes previously not implicated in sperm biology using the Drosophila model system and identified 41 novel spermatogenesis genes required for normal fertility. Furthermore, by exploring exome/genome sequencing data of infertile men with severe spermatogenic impairment, we found that the human orthologs of the gorilla relaxed genes are enriched for loss-of-function variants in infertile men. These data provide compelling evidence that reduced sperm competition in gorillas is associated with relaxed purifying selection on genes related to male reproductive function. The accumulation of deleterious mutations in these genes likely provides the mechanistic basis behind the low efficacy of gorilla spermatogenesis and uncovers new candidate genes for human male infertility.</p>
Experimental evolution of Dictyostelium discoideum cheating under relaxed selection
<p>Many microbes interact with one another, but the difficulty of directly observing these interactions in nature makes interpreting their adaptive value complicated. The social amoeba <em>Dictyostelium discoideum </em>forms aggregates<em> </em>wherein some cells are sacrificed for the benefit of others. Within chimeric aggregates containing multiple unrelated lineages, cheaters can gain an advantage by undercontributing, but the extent to which wild <em>D. discoideum </em>has adapted to cheat is not fully clear. In this study, we experimentally evolved <em>D. discoideum </em>in an environment where there were no selective pressures to cheat or resist cheating in chimeras. <em>D. discoideum </em>lines grown in this environment evolved reduced competitiveness within chimeric aggregates and reduced ability to migrate during the slug stage. By contrast, we did not observe a reduction in cell number, a trait for which selection was not relaxed. The observed loss of traits that our laboratory conditions had made irrelevant suggests that these traits were adaptations driven and maintained by selective pressures <em>D. discoideum </em>faces in its natural environment. Our results suggest that <em>D. discoideum</em> faces social conflict in nature, and illustrate a general approach that could be applied to searching for social or non-social adaptations in other microbes.</p>
Relaxed selection and the evolution of Chasmogamous flower of Impatiens capensis
<p><span><span><span><span><span><span><span><span><span><span><span>We exploited ecotypic variation in <i>Impatiens capensis</i> to test the hypothesis that mutation accumulation accompanying relaxed selection on the chasmogamous (CH) flower leads to more variable flower shapes and smaller flowers. Sun ecotype populations of this species occur along sunny riverbanks and marshes and produce both CH and cleistogamous (CL) flowers, while shade ecotype populations occur in shady forest floors and produce only CL flowers. In the shade ecotype, it is assumed that selection on the CH flower has been relaxed. Seedlings from population samples of the two ecotypes exhibited different first internode growth responses to low ratio of red:far-red light characteristic of ecotypic differentiation to either sunny or shady conditions, helping to verify historical illumination conditions in the populations. We examined the CH floral mutation accumulation hypothesis by comparing the shape and size of the modified CH flower sepal under greenhouse conditions that triggered CH flowering in plants of both ecotypes. Contrary to our predictions, geometric morphometric analysis of sepal shape variation levels indicated little difference between the shade and sun ecotypes. We suggest that mutations that influence CH flower shape may have pleiotropic effects on structures or processes that remain under selection even when the CH flowers are not produced. On the other hand, sepal size was significantly smaller in the shade ecotype populations. In the case of CH sepal size, the mutational effects appear to be directional, towards the production of smaller sepals, and likely would be deleterious if shade ecotype plants encountered sunnier conditions where CH flowers could be produced. </span></span></span></span></span></span></span></span></span></span></span></p>
Illuminating the mystery of thylacine extinction: A role for relaxed selection and gene loss
Open the record for dataset details and reuse information.
Mimicry in motion and morphology: do information limitation, trade-offs or compensation relax selection for mimetic accuracy?
Open the record for dataset details and reuse information.
Data from: Ancient climate changes and relaxed selection shape cave colonization in North American cavefishes
Open the record for dataset details and reuse information.
Pervasive relaxed selection on spermatogenesis genes in gorillas coincident with the evolution of polygyny
Open the record for dataset details and reuse information.
Male and female adult zebra finch (Taeniopygia guttata) gonad RNAseq associated with: Relaxed purifying selection maintains a sex-linked supergene polymorphism in zebra finches
Open the record for dataset details and reuse information.
Data from: Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection
Open the record for dataset details and reuse information.
Caecilians maintain a functional long-wavelength-sensitive cone opsin gene despite signatures of relaxed selection and more than 200 million years of fossoriality
Open the record for dataset details and reuse information.
Data from: Enhanced seed defenses potentially relax selection by seed predators against serotiny in lodgepole pine
Open the record for dataset details and reuse information.
Experimental evolution of Dictyostelium discoideum cheating under relaxed selection
Open the record for dataset details and reuse information.
Data from: Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals
Open the record for dataset details and reuse information.
Feather evolution following flight loss in crown group birds: relaxed selection and developmental constraints
Open the record for dataset details and reuse information.
Relaxed selection and the evolution of Chasmogamous flower of Impatiens capensis
Open the record for dataset details and reuse information.
Habitat deterioration relaxes resource competition and sexual selection in the threespine stickleback
The operation of sexual selection depends on ecological conditions. Thus, changes in environmental conditions because of human activities can alter the strength and direction of sexual selection, with implications for evolutionary trajectories and the viability of populations. We show that aquatic algal blooms can relax the operation of sexual selection by influencing which males are available to attract females. This is by influencing the ability of males to maintain a resource needed in mate attraction. When we exposed two competing threespine stickleback males (Gasterosteus aculeatus), whose attractiveness to females was known, to either clear or algal-turbid water, nest abandonment was more common in clear water, and it was usually the unattractive male that abandoned his nest. In turbid water, on the other hand, nest abandonments were less common and when they occurred, the probability increased that the attractive male abandoned his nest, and that the unattractive male subsequently occupied it. This change in the composition of nesting males increased the mating success of unattractive males. Thus, our results reveal a new mechanism through which habitat deterioration can influence sexual selection, by altering success in the competition for a resource critical in mate attraction, a territory with a nest in this case. This could be a common mechanism, considering the prevalence of resource competition in mate choice systems. On a broader level, our results emphasise the importance of considering the impact of environmental changes on the outcome of resource competition when investigating the influence that environmental disturbances have on the operation of sexual selection and thereby on evolutionary processes and population dynamics.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.