Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
27
datasets available to search
ShareScore release 0.9.0
Dataset results
27 results for “resistance durability”
Resistive switching memories with enhanced durability enabled by mixed-dimensional perfluoroarene perovskite heterostructures
<p><span>Characterisation dataset for “</span><span>Resistive switching memories with enhanced durability enabled by mixed-dimensional perfluoroarene perovskite heterostructures”</span><span>, DOI:</span><span>10.1039/d4nh00104d</span><span>. Data for main and supporting figures provided as *.xlsx and *.txt files.</span></p> <p> </p> <p> </p> <p> </p>
I alternate therefore I generalize: how the intrinsic resistance risk of fungicides counterbalances their durability
<p>The evolution of resistance to pesticides is a major burden in agriculture. Resistance management involves maximizing selection pressure heterogeneity, particularly by combining active ingredients with different modes of action. We tested the hypothesis that alternation may delay the build-up of resistance not only by spreading selection pressure over longer periods, but also by decreasing the rate of evolution of resistance to alternated fungicides, by applying an experimental evolution approach to the economically important crop pathogen <i>Zymoseptoria tritici. </i>Our results show that alternation is either neutral or slows the evolution of resistance, relative to continuous fungicide use, but results in higher levels of generalism in evolved lines. We demonstrate that the relative risk of resistance intrinsic to fungicide alternation probably underlies a trade-off between the number of fungicides and the frequency of alternation. This trade-off is also dynamic over the course of resistance evolution. These findings open up new possibilities for tailoring resistance management effectively while optimizing interplay between alternation components.</p>
I alternate therefore I generalize: how the intrinsic resistance risk of fungicides counterbalances their durability
Open the record for dataset details and reuse information.
A roadmap to durable BCTV resistance using long-read genome assembly of genetic stock KDH13
<p>PacBio Sequence data associated with genetic stock KDH13.Datasets include genome resources and annotated files associated with the manuscript "Long-read genome assembly of Double Haploid Sugar Beet KDH13 provides roadmap for durable genetic resistance to Beet Curly Top Virus". This includes genome assembly, ordered genome assembly, protein predictions, variant call format files for an F1 hybrid (KDH13xKDH19-17).</p>
Durable resistance or efficient disease control? Adult Plant Resistance (APR) at the heart of the dilemma [Dataset]
<p>Dataset of simulation results used in this study (https://doi.org/10.24072/pcjournal.271):</p> <p><strong>Durable resistance or efficient disease control? Adult Plant Resistance (APR) at the heart of the dilemma.</strong></p> <p>published in Peer Community Journal.</p> <p> </p> <p>All simulations are computed using the R package landsepi<br> Package webpage: https://csiro-inra.pages.biosp.inrae.fr/landsepi/<br> To download the package: https://cran.r-project.org/web/packages/landsepi/index.html</p> <p>Raw data used for this study are stored in three folders corresponding to<br> the three numerical experiments (APR_1, APR_2 and APR_3, respectively).</p> <p>Every folder includes:<br> - an R script for the generation of a simulation plan<br> - 10 folders containing simulation results for 10 stochastic replicates<br> - an R script for the analysis of the results and generation of graphics</p> <p>Every folder containing the simulation results includes:<br> - a text file "myDesign.txt" containing the simulation plan and outputs (1 line per simulation)<br> - a text file "parameters.txt" containing a summary of all parameter values<br> - a text file "param_disp_patho.txt" containing the dispersal matrix of the pathogen<br> - a text file "param_landscape.txt" containing the landscape structure<br> (i.e. for every polygon [lines] and every year [columns] the index of the cultivated host)</p>
A Study to Assess Resistance and Durability of Response to ABT-493 and/or ABT-530
ClinicalTrials.gov study NCT02441283. IPD Sharing: YES. Countries: 8. Publications: 1.
A roadmap to durable BCTV resistance using long-read genome assembly of genetic stock KDH13
Open the record for dataset details and reuse information.
Advances in grape and pathogen genomics toward durable grapevine disease resistance
<p>Repository for supplementary Tables to the Expert Views paper: Advances in grape and pathogen genomics toward durable grapevine disease resistance.</p> <p>Table S1. Disease resistance loci identified in grapes.<br>Table S2. Grape pathogen genome assemblies.</p> <p>Funding: <br>This work was funded by the US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Award #2022-51181-38240 and partially supported by the Ray Rossi Endowment in Viticulture and Enology and the E.J. Gallo Winery.</p>
Durability of Virologic Response and/or Viral Resistance Patterns in Participants With Chronic Hepatitis C Who Have Been Previously Treated With Grazoprevir (MK-5172) (MK-5172-017)
ClinicalTrials.gov study NCT01667081. IPD Sharing: YES. Countries: 0. Publications: 1.
Data from:Insight into the durability of plant resistance to aphids from a demo-genetic study of Aphis gossypii in melon crops
Open the record for dataset details and reuse information.
Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational basis for sustainable resistance breeding in plants
The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve the durability of resistant cultivar, as recently observed in different pathosystems. Using the pepper (Capsicum annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we aimed at identifying plant genetic factors directly affecting the frequency of virus adaptation to the major resistance gene pvr23 and at comparing them with genetic factors affecting quantitative resistance. The resistance breakdown frequency was a highly heritable trait (h²=0.87). Four loci including additive quantitative trait loci (QTLs) and epistatic interactions explained together 70% of the variance of pvr23 breakdown frequency. Three of the four QTLs controlling pvr23 breakdown frequency were also involved in quantitative resistance, strongly suggesting that QTLs controlling quantitative resistance have a pleiotropic effect on the durability of the major resistance gene. With the first mapping of QTLs directly affecting resistance durability, this study provides a rationale for sustainable resistance breeding. Surprisingly, a genetic trade-off was observed between the durability of PVY resistance controlled by pvr23 and the spectrum of the resistance against different potyviruses. This trade-off seemed to have been resolved by the combination of minor-effect durability QTLs under long term farmer selection.
An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)-
ClinicalTrials.gov study NCT01168856. IPD Sharing: Not stated. Countries: 15. Publications: 0.
Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational basis for sustainable resistance breeding in plants
Open the record for dataset details and reuse information.
Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response [Tru-seq]
GEO Series GSE255847. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
GEO Series GSE245517. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity [TCR-seq]
GEO Series GSE158608. Mus musculus. 23 samples. Type: Other.
Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response (Quant-Seq).
GEO Series GSE225059. Homo sapiens. 97 samples. Type: Expression profiling by high throughput sequencing.
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity [RNA-seq]
GEO Series GSE158607. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response (RNA-Seq).
GEO Series GSE225060. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Combination of a SOS1-KRAS interaction inhibitor with a KRASG12C inhibitor combination can address intrinsic and acquired resistance leading to stronger and more durable response
GEO Series GSE225061. Homo sapiens. 217 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.