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147 results for “retinal ganglion cells”
Feedback from retinal ganglion cells to the inner retina
<p>This repository contains the data files and codes used in the following paper:</p> <p>Feedback from retinal ganglion cells to the inner retina<br> Anastasiia Vlasiuk, Hiroki Asari<br> PLOS One (accepted)</p> <p>The preprint is also available from bioRxiv 2020.08.30.274514.</p>
Data from: Zebrafish retinal ganglion cells asymmetrically encode spectral and temporal information across visual space
<p>In vertebrate vision, the tetrachromatic larval zebrafish permits non-invasive monitoring and manipulating of neural activity across the nervous system in vivo during ongoing behaviour. However, despite a perhaps unparalleled understanding of links between zebrafish brain circuits and visual behaviours, comparatively little is known about what their eyes send to the brain via retinal ganglion cells (RGCs). Major gaps in knowledge include any information on spectral coding, and information on potentially critical variations in RGC properties across the retinal surface corresponding with asymmetries in the statistics of natural visual space and behavioural demands. Here, we use in vivo two photon (2P) imaging during hyperspectral visual stimulation as well as photolabeling of RGCs to provide a functional and anatomical census of RGCs in larval zebrafish. We find that RGCs' functional and structural properties differ across the eye and include a notable population of UV-responsive On-sustained RGCs that are only found in the acute zone, likely to support visual prey capture of UV-bright zooplankton. Next, approximately half of RGCs display diverse forms of colour opponency including many that are driven by a pervasive and slow blue-Off system - far in excess of what would be required to satisfy traditional models of colour vision. In addition, most information on spectral contrast was intermixed with temporal information. Taken together, our results suggest that zebrafish RGCs send a diverse and highly regionalised time-colour code to the brain.</p>
Classification of pseudocalcium visual responses from mouse retinal ganglion cells
<p>The dataset includes spike data of 9 different recordings from mouse retina ganglion cells and the <em>Pseudocalcium </em>traces after convolving spikes with OGB kernel.</p>
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.
<p>This is the source file to be use for debugging problems on your own set-up. This files is a good example to both the repository provided for visual processing on the Kremow GitHub:</p> <p>https://github.com/KremkowLab/Axon-on-Neuropixels-in-Kilosort</p> <p>https://github.com/KremkowLab/tangential_recording</p>
Data from: Zebrafish retinal ganglion cells asymmetrically encode spectral and temporal information across visual space
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Optogenetic response of mouse and macaque retinal ganglion cells
<p>Data presented in "Towards optogenetic vision restoration with high resolution"<br> BioRxiv https://www.biorxiv.org/content/10.1101/470773v1, to appear in PLOS Computational Biology.<br> Please cite this paper if the data have been useful for you.</p> <p>Data contains multi-electrode array recordings of optogenetic response of retinal ganglion cells subject to checkerboard visual stimulation.<br> Mouse: blind rd1 mice (4-5 weeks old) with an AAV2 encoding ReaChR-mCitrine under a pan-neuronal hSyn promoter via intravitreal injections. <br> Macaque: retinal ganglion cells have been targeted with an AAV2 encoding a human codon optimized CatCh under a strong, RGC-specific promoter. Retinas were harvested three months after injection of the virus in the adult macaque retina.</p>
Axial currents recordings in mouse retinal ganglion cells
<p>Patch-clamp recordings in mouse retinal ganglion cells performed by Martijn Sierksma. It comprises axial currents recorded in voltage clamp, spontaneous activity and the response to current pulses. The cells were filled with biocytin and subsequently labelled for ankyrin G. The dataset comprises confocal images of the full neurons morphology and their axon initial segments performed by Sarah Goethals. </p> <p> </p>
Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses
<p>All data used in the study https://doi.org/10.1101/2023.01.12.523643 can be found here. </p>
Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues
ClinicalTrials.gov study NCT07074782. IPD Sharing: Not stated. Countries: 5. Publications: 30.
Efficacy of Nicotinamide on Retinal Ganglion Cell Functions in Glaucoma Patients
ClinicalTrials.gov study NCT06078605. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Morphometric analysis of retinal ganglionic cells (3D confocal images) analyzed using filament tracer from Imaris software
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Retinofugal projections from melanopsin-expressing retinal ganglion cells revealed by intraocular injections of Cre-dependent virus
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Type-specific dendritic integration in mouse retinal ganglion cells
<p>Dataset for <a href="https://www.biorxiv.org/content/10.1101/753335v1.abstract">Ran et al (2020)</a>. These data can be read by Python (>3.6) and Pandas (>1.0.0):</p> <pre><code class="language-python">import pickle data = pickle.load(open('./data_raw.pickle', 'rb')) </code></pre> <p>Or use our custom scripts. For more details, see <a href="https://github.com/berenslab/rgc_dendrites">https://github.com/berenslab/rgc_dendrites</a>. </p>
Data from: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are involved in circadian and other non-image forming visual responses. An open question is whether the activity of these neurons may also be under the regulation mediated by the neurohormone melatonin. In the present work, by double-staining immunohistochemical technique, we studied the expression of MT1 and MT2, two known subtypes of mammalian melatonin receptors, in rat ipRGCs. A single subset of retinal ganglion cells labeled by the specific antibody against melanopsin exhibited the morphology typical of M1-type ipRGCs. Immunoreactivity for both MT1 and MT2 receptors was clearly seen in the cytoplasm of all labeled ipRGCs, indicating that these two receptors were co-expressed in each of these neurons. Furthermore, labeling for both the receptors were found in neonatal M1 cells as early as the day of birth. It is therefore highly plausible that retinal melatonin may directly modulate the activity of ipRGCs, thus regulating non-image forming visual functions.
Data from: The functional diversity of retinal ganglion cells in the mouse
In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such 'output channels' exist and what each encodes are areas of intense debate. In the mouse, anatomical estimates range from 15 to 20 channels, and only a handful are functionally understood. By combining two-photon calcium imaging to obtain dense retinal recordings and unsupervised clustering of the resulting sample of more than 11,000 cells, here we show that the mouse retina harbours substantially more than 30 functional output channels. These include all known and several new ganglion cell types, as verified by genetic and anatomical criteria. Therefore, information channels from the mouse eye to the mouse brain are considerably more diverse than shown thus far by anatomical studies, suggesting an encoding strategy resembling that used in state-of-the-art artificial vision systems.
Stop Retinal Ganglion Cell Dysfunction Study
ClinicalTrials.gov study NCT02390284. IPD Sharing: NO. Countries: 1. Publications: 0.
The functional organization of excitation and inhibition in the dendritic arbors of retinal direction-selective ganglion cells
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Data from: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells
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Data from: The functional diversity of retinal ganglion cells in the mouse
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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.