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ShareScore release 0.9.0
Dataset results
26 results for “reversible plasticity”
Data from: Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate
<p>Mechanical properties such as substrate stiffness are a ubiquitous feature of a cell's environment. Many types of animal cells exhibit canonical phenotypic plasticity when grown on substrates of differing stiffness, in vitro and in vivo. Whether such plasticity is a multivariate optimum due to hundreds of millions of years of animal evolution, or instead is a compromise between conflicting selective demands, is unknown. We addressed these questions by means of experimental evolution of populations of mouse fibroblasts propagated for approximately 90 cell generations on soft or stiff substrates. The ancestral cells grow twice as fast on stiff substrate as on soft substrate and exhibit the canonical phenotypic plasticity. Soft-selected lines derived from a genetically diverse ancestral population increased growth rate on soft substrate to the ancestral level on stiff substrate and evolved the same multivariate phenotype. The pattern of plasticity in the soft-selected lines was opposite of the ancestral pattern, suggesting that reverse plasticity underlies the observed rapid evolution. Conversely, growth rate and phenotypes did not change in selected lines derived from clonal cells. Overall, our results suggest that the changes were the result of genetic evolution and not phenotypic plasticity per se. Whole-transcriptome analysis revealed consistent differentiation between ancestral and soft-selected populations, and that both emergent phenotypes and gene expression tended to revert in the soft-selected lines. However, the selected populations appear to have achieved the same phenotypic outcome by means of at least two distinct transcriptional architectures related to mechanotransduction and proliferation.</p>
Data from: Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate
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Dataset from Maith, O., Baladron, J., Einhäuser, W., & Hamker, F. H. (2023). Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model. Submitted to iScience.
<p>This dataset contains all analyzed data from the study "Maith, O., Baladron, J., Einhäuser, W., & Hamker, F. H. (2023). Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model. Submitted to iScience.". It includes the behavioral data of 20 human participants (folder "psychExp") and of simulations of a neuro-computational basal ganglia model (folder "simulations") of the study.</p> <p>To replicate the results of the study, the dataset can be analyzed using the code provided separately under the following identifier: https://doi.org/10.5281/zenodo.6555886. The dataset is organized in the directory structure required for this purpose.</p> <p>For the human participants, only preprocessed eye-tracking and general behavioral data (.mat files) and the final analyzed behavioral data (output files) generated with the script "get_vps_outputs.m" (folder psychExp/..../3_srcAna/) are available. For more information about preprocessing steps as well as raw data of the eye-tracking experiment, please contact us by email (click <a href="https://www.tu-chemnitz.de/urz/mail/adrx.html?1-d29sZmdhbmcuZWluaGFldXNlci10cmV5ZXJAcGh5c2lrLg==">here</a>).</p>
Data from: Reversible plasticity in the communication system of the cricket <em>Gryllus rubens</em>
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Phenotypic plasticity can reverse the relative extent of intra and interspecific variability across a thermal gradient
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Reversible plasticity in brain size, behavior, and physiology characterizes caste 2 transitions in a socially flexible ant (Harpegnathos saltator)
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NSD2 targeting reverses plasticity and drug resistance in prostate cancer
GEO Series GSE237197. Mus musculus. 91 samples. Type: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas [CUT&Tag]
GEO Series GSE250484. Mus musculus. 44 samples. Type: Other.
NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [multiome snRNA-seq]
GEO Series GSE237195. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas [scRNA-seq]
GEO Series GSE250486. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic reversal of lineage plasticity enhances responsiveness to anti-GD2 therapy in neuroblastoma
GEO Series GSE180516. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas [scATAC-seq]
GEO Series GSE250485. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [scRNA-seq]
GEO Series GSE237191. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [snATAC-seq and multiome snATAC-seq]
GEO Series GSE237196. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: The coevolution of lifespan and reversible plasticity
Reversible phenotypic plasticity, the ability to change one's phenotype repeatedly throughout life, can be selected for in environments that do not stay constant throughout an individual's lifetime. It might also mitigate senescence, as the mismatch between the varying environment and a non-plastic individual's traits is likely to increase as time passes. To understand why reversible plasticity may covary with lifespan, studies tend to assume unidirectional causality: plasticity evolves under suitable rates of environmental variation with respect to life history. Here we show that if lifespan also evolves in response to plasticity, then long life is not merely a context that sets the stage for lifelong plasticity. Instead, the causality is bidirectional because plasticity itself can select for longevity. Highly autocorrelated environmental fluctuations predict low investment in reversible plasticity and a phenotype that is poorly matched to the environment at older ages. Such environments select for high reproductive effort and short lifespans.
Functional plasticity and reversible growth behavior of patients’ acute myeloid leukemia stem cells growing in mice
GEO Series GSE141627. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Data from: The coevolution of lifespan and reversible plasticity
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NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [bulk RNA-seq]
GEO Series GSE308993. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [Cut&Tag]
GEO Series GSE308575. Mus musculus. 58 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic reversal of lineage plasticity enhances responsiveness to anti-GD2 therapy in neuroblastoma [RNA-seq SK-N-AS]
GEO Series GSE180512. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.