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278 results for “sarcoidosis”
Data to "Cardiopulmonary exercise testing complements both spirometry and nuclear imaging for assessing sarcoidosis disease stage and for monitoring disease activity"
<p>This record contains analysis scripts (written in Matlab) as well as raw and processed data to reproduce the results shown in:</p> <p>Torregiani, C., Reale, M., Confalonieri, M., Dore, F., Crisafulli, C., Baratella, E., ... & Maiello, G. (2024). Cardiopulmonary exercise testing complements both spirometry and nuclear imaging for assessing sarcoidosis stage and for monitoring disease activity. <em>Sarcoidosis, Vasculitis, and Diffuse Lung Diseases</em>, 41(1), e2024017-e2024017. https://doi.org/10.36141/svdld.v41i1.15125</p>
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis
<p><span><strong>Rationale</strong>: </span><span>The role of the pulmonary microbiome in sarcoidosis is unknown.</span><br><br><span><strong>Objectives</strong>: </span><span>The objectives of the current study was to: 1) </span><span>Examine whether the pulmonary fungal and bacterial microbiota differed in patients with sarcoidosis compared with controls. 2) Examine whether there was an association between the microbiota and levels of the antimicrobial peptides (AMPs) in protected bronchoalveolar lavage (PBAL), indicating an interaction with the innate immune response.</span><br><br><span><strong>Methods</strong>: </span><span>35 sarcoidosis patients and 35 healthy controls underwent bronchoscopy and were sampled with oral wash (OW), protected BAL (PBAL) and left protected sterile brushes (LPSB). The fungal ITS1 region and the V3V4 region of the bacterial 16SrDNA gene were sequenced. Bioinformatic analyses were performed with QIIME 2. The AMPs secretory leucocyte protease inhibitor (SLPI) and human beta defensins 1 and 2 (hBD-1 & hBD-2), were measured in PBAL by enzyme linked immunosorbent assay (ELISA).</span><br><br><span><strong>Measurements and Main Results</strong>: </span><em><span>Aspergillus</span></em><span> dominated the PBAL samples in sarcoidosis. Differences in bacterial taxonomy were minor. There was no significant difference in fungal alpha diversity between sarcoidosis and controls, but the bacterial alpha diversity in sarcoidosis was significantly lower in OW (p=0.047) and PBAL (p=0.03) compared with controls. The beta diversity for sarcoidosis compared with controls differed for both fungi and bacteria. AMP levels were significantly lower in sarcoidosis compared to controls (SLPI & hBD-1: p<0.01). No significant correlations were found between </span><span>a</span><span>-diversity and AMPs.</span><br><br><span><strong>Conclusions</strong>: </span><span>The pulmonary fungal and bacterial microbiota in sarcoidosis differed from controls, with lower antimicrobial peptides levels in sarcoidosis.</span></p>
Trial of Antimycobacterial Therapy in Sarcoidosis
ClinicalTrials.gov study NCT01074554. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
ClinicalTrials.gov study NCT02265874. IPD Sharing: NO. Countries: 1. Publications: 2.
Acthar Gel in Participants With Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT03320070. IPD Sharing: NO. Countries: 1. Publications: 1.
Tadalafil for Sarcoidosis Associated Pulmonary Hypertension
ClinicalTrials.gov study NCT01324999. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis
ClinicalTrials.gov study NCT04017936. IPD Sharing: NO. Countries: 1. Publications: 2.
Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis
ClinicalTrials.gov study NCT04008069. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Atorvastatin to Treat Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT00279708. IPD Sharing: NO. Countries: 1. Publications: 3.
Tofacitinib Hypothesis-generating, Pilot Study for Corticosteroid-Dependent Sarcoidosis
ClinicalTrials.gov study NCT03793439. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis
ClinicalTrials.gov study NCT00955279. IPD Sharing: Not stated. Countries: 9. Publications: 3.
A Study to Assess the Efficacy and Safety of Namilumab in Participants With Chronic Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT05314517. IPD Sharing: NO. Countries: 7. Publications: 0.
Trial of Adalimumab in Progressive Sarcoidosis
ClinicalTrials.gov study NCT00311246. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CNS Sarcoidosis and Acthar Gel
ClinicalTrials.gov study NCT02298491. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT01169038. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT03824392. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis
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Sarcoidosis Microbiome Post-Processed Sequence Data
<p>16S, ITS, virome and shotgun sequencing data after demultiplexing, quality control, OTU formation (if relevant) and taxonomic assignment for the sarcoidosis microbiome project.</p> <p>This is intended to be used in conjunction with the code at https://github.com/eclarke/sarcoid-microbiome-paper to reproduce the analysis performed for the associated paper (citation pending acceptance/publication).</p> <p> </p> <p> </p>
An RCT of NBI vs. White Light Guided Endobronchial Biopsy in Suspected Sarcoidosis
ClinicalTrials.gov study NCT05311150. IPD Sharing: NO. Countries: 1. Publications: 1.
Risk Indicators of Sarcoidosis Evolution-Unified Protocol
ClinicalTrials.gov study NCT05567133. IPD Sharing: NO. Countries: 1. Publications: 1.
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