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36 results for “sarcomere”
Automated sarcomere detection Matlab tool
<p>The Matlab code presented was developed by Dr. Ian Estabrook in 2019-2023 to automatically detect sarcomeres in multi-channel z-stack images of developing myofibrils, as used in the preprint: "A tension-driven sarcomere division mechanism facilitates muscle growth" by Clement Rodier, Ian Estabrook, Vincent Loreau, Dirk Görlich, Benjamin M. Friedrich, Frank Schnorrer. We thank Yasmin Magdy Emadeldin Mohamed Abdelghaffar for help with preparing this repository and the documentation of the code. An example data set with corresponding sarcomere tracking is included.</p>
Sarcomere organization
<p>Dataset of sarcomere organization, including filament directionality, network density, sarcomere length and z-Disc thickness</p>
Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation
<p>The force-length relation is one of the most defining features of the sliding filament theory of muscle contraction, and yet a topic of debate in the literature. The force-length relation predicts that the force produced by muscle fibers is directly proportional to the degree of overlap between myosin and actin filaments, but several studies have shown forces that are larger than predicted, especially at long sarcomere lengths. The reason for such discrepancies may be due to technical difficulties – studies have been conducted with muscle fibers, a preparation containing thousands of sarcomeres that makes accurate length measurements challanging. The aim of this study was to directly evaluate force production and sarcomere dynamics in isolated myofibrils and single sarcomeres to enhance our understanding about mechanisms governing deviations from the theoretically predicted force-length relation. Contractions at varying sarcomere lengths (SLs) along the plateau (SL=2.25m-2.39m) and the descending limb (SL>2.39m) of the force-length relation were induced by solution switching, and different modes of force measurements were used. Our results show that single sarcomeres and extrapolated forces resemble the theoretical force-length relation closely, while myofibrils with sarcomere length dispersions show an extension of the plateau region and forces elevated above predicted levels. We also found an increase in sarcomere length non-uniformity and slowed rate of force production at long lengths in myofibrils with sarcomeres in series but not in single sarcomere preparations. We conclude that the deviation of the descending limb of the force-length relation obtained from plateau forces is correlated with the degree of sarcomere length non-uniformity and slowed force development.</p>
Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM
ClinicalTrials.gov study NCT01912534. IPD Sharing: Not stated. Countries: 2. Publications: 7.
Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation
Open the record for dataset details and reuse information.
Striated myocyte structural integrity: automated analysis of sarcomeric z-discs
Open the record for dataset details and reuse information.
COMSOL models of fluid flow in the sarcomere
Open the record for dataset details and reuse information.
The Skeletal Muscle Molecular Clock Regulates Sarcomere Length Through Titin Splicing [2]
GEO Series GSE189863. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Sorafenib induces cardiotoxicity through RBM20 mediated alternative splicing of sarcomeric and mitochondrial genes
GEO Series GSE222642. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
H3K27me3 deposition over sarcomeric and cytoskeletal promoters is required for cardiomyocyte cytokinesis and wound invasion during zebrafish heart regeneration [ChIP-seq]
GEO Series GSE96928. Danio rerio. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
GEO Series GSE215304. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer [RNA-seq]
GEO Series GSE282670. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
The Skeletal Muscle Molecular Clock Regulates Sarcomere Length Through Titin Splicing [1]
GEO Series GSE172067. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Functional TDP-43 amyloids bind sarcomeric mRNA to direct skeletal muscle formation
GEO Series GSE104796. Mus musculus. 8 samples. Type: Other.
Contribution of hypoxia-inducible 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
GEO Series GSE266649. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer [scRNA-Seq]
GEO Series GSE282693. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
GEO Series GSE283867. Homo sapiens; Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis
GEO Series GSE296707. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
H3K27me3 deposition over sarcomeric and cytoskeletal promoters is required for cardiomyocyte cytokinesis and wound invasion during zebrafish heart regeneration [RNA-seq]
GEO Series GSE96929. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy due to sarcomere disruption and protein aggregate formation
GEO Series GSE166862. Mus musculus. 234 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.