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Dataset results
102 results for “schwannoma”
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
<p>Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells, and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N>170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a 9-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.</p>
Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma
<p>Recent<b> </b>discoveries of transmissible cancers in multiple bivalve species suggest that direct transmission of cancer cells within species may be more common than previously thought, particularly in aquatic environments. Fibropapillomatosis occurs with high prevalence in green sea turtles (Chelonia mydas) and the geographic range of disease has increased since fibropapillomatosis was first reported in this species. Widespread incidence of schwannomas, benign tumours of Schwann cell origin, reported in aquarium-bred goldfish (Carassius auratus), suggest an infectious aetiology. We investigated the hypothesis that cancers in these species arise by clonal transmission of cancer cells. Through analysis of polymorphic microsatellite alleles, we demonstrate concordance of host and tumour genotypes in diseased animals. These results imply that the tumours examined arose from independent oncogenic transformation of host tissue and were not clonally transmitted. Further, failure to experimentally transmit goldfish schwannoma via water exposure or inoculation suggest that this disease is unlikely to have an infectious aetiology.</p>
Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)
ClinicalTrials.gov study NCT01207687. IPD Sharing: NO. Countries: 1. Publications: 1.
Vestibular Rehabilitation Protocol in Unilateral Vestibular Schwannoma
ClinicalTrials.gov study NCT07364955. IPD Sharing: YES. Countries: 1. Publications: 4.
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
ClinicalTrials.gov study NCT02282917. IPD Sharing: NO. Countries: 1. Publications: 2.
Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560
ClinicalTrials.gov study NCT04351373. IPD Sharing: NO. Countries: 1. Publications: 1.
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
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Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma
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Data from: High-dimensional imaging of vestibular schwannoma reveals distinctive immunological networks across histomorphic niches in NF2-related schwannomatosis
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Seurat objects for "Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state" (https://doi.org/10.1038/s41467-023-42762-w)
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Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function
ClinicalTrials.gov study NCT02415257. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients with Vestibular Schwannomas
ClinicalTrials.gov study NCT05702749. IPD Sharing: NO. Countries: 1. Publications: 3.
Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
ClinicalTrials.gov study NCT01938677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Use of Virtual Reality in Rehabilitation in Patients After Vestibular Schwannoma Surgery.
ClinicalTrials.gov study NCT05578560. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vestibular Evaluation After Vestibular Schwannoma Treatment
ClinicalTrials.gov study NCT03670589. IPD Sharing: NO. Countries: 1. Publications: 4.
Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma
ClinicalTrials.gov study NCT07130851. IPD Sharing: YES. Countries: 1. Publications: 2.
Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma
ClinicalTrials.gov study NCT03958006. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Doxycycline in Cutaneous Schwannoma (NF2)
ClinicalTrials.gov study NCT05521048. IPD Sharing: Not stated. Countries: 1. Publications: 28.
Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma
ClinicalTrials.gov study NCT01199978. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RGD PET/MRI in Sporadic Vestibular Schwannoma
ClinicalTrials.gov study NCT03393689. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.