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5 results for “selective autophagy receptors”
Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage
<p>The dataset contains all the original raw files for the following study:</p> <p><strong>Metabolic enzymes moonlight as selective autophagy receptors </strong><strong>to protect plants against viral-induced cellular damage</strong></p> <p>Marion Clavel<sup>1,2,*</sup>, Anita Bianchi<sup>1</sup>, Roksolana Kobylinska<sup>1</sup>, Roan Groh<sup>1,3</sup>, Juncai Ma<sup>4</sup>, Ranjith K. Papareddy<sup>1</sup>, Nenad Grujic<sup>1</sup>, Lorenzo Picchianti<sup>1,3</sup>, Ethan Stewart<sup>5</sup>, Michael Schutzbier<sup>1</sup>, Karel Stejskal<sup>1</sup>, Juan Carlos de la Concepcion<sup>1</sup>, Victor Sanchez de Medina Hernandez<sup>1,3</sup>, Yoav Voichek<sup>1</sup>, Pieter Clauw<sup>1</sup><strong>, </strong>Joanna Gunis<sup>1</sup>, Gerhard Durnberger<sup>1</sup>, Jens Christian Muelders<sup>2</sup>, Annett Grimm<sup>2</sup>, Arthur Sedivy<sup>5</sup>, Mathieu Erhardt<sup>6</sup>, Victoria Vyboishchikov<sup>1</sup>, Peng Gao<sup>1</sup>, Esther Lechner<sup>6</sup>, Emilie Vantard<sup>6</sup>, Jakub Jez<sup>5</sup>, Elisabeth Roitinger<sup>1</sup>, Pascal Genschik<sup>6</sup>, Byung-Ho Kang<sup>4</sup>, Yasin Dagdas<sup>1,*</sup></p> <p><strong> </strong></p> <p><strong>Affiliations</strong></p> <p><sup>1</sup>Gregor Mendel Institute, Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.</p> <p><sup>2</sup>Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany</p> <p><sup>3</sup>Vienna BioCenter PhD Program, Doctoral School of the University at Vienna and Medical University of Vienna, Vienna, Austria</p> <p><sup>4</sup>School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China</p> <p><sup>5</sup>Vienna Biocenter Core Facilities (VBCF), Vienna, Austria</p> <p><sup>6</sup>Institut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, 12, rue du Général Zimmer, 67084 Strasbourg, France</p> <p> </p> <p>*Correspondence: Marion Clavel (marion.clavel@mpimp-golm.mpg.de),</p> <p> Yasin Dagdas (yasin.dagdas@gmi.oeaw.ac.at)</p> <p><strong> </strong></p> <p><strong>Abstract</strong></p> <p>RNA viruses co-opt the host endomembrane system and organelles to build replication complexes for infection. How the host responds to these membrane perturbations is poorly understood. Here, we explore the autophagic response of <em>Arabidopsis thaliana</em> to three viruses that hijack different cellular compartments. Autophagy is significantly induced within systemically infected tissues, its disruption rendering plants highly sensitive to infection. Contrary to being an antiviral defense mechanism as previously suggested, quantitative analyses of the viral loads established autophagy as a tolerance pathway. Further analysis of one of these viruses, the Turnip Crinkle Virus (TCV) that hijack mitochondria, showed that despite perturbing mitochondrial integrity, TCV does not trigger a typical mitophagy response. Instead, TCV and Turnip yellow mosaic virus (TYMV) infection activates a distinct selective autophagy mechanism, where oligomeric metabolic enzymes moonlight as selective autophagy receptors and degrade key executors of defense and cell death such as EDS1. Altogether, our study reveals an autophagy-regulated metabolic rheostat that gauges cellular integrity during viral infection and degrades cell death executors to avoid catastrophic amplification of immune signaling.</p> <p> </p> <p>One archive corresponds to one main or supplemental figure.</p>
Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral induced cellular damage
GEO Series GSE264734. Arabidopsis thaliana. 16 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of the selective autophagy receptor AtNBR1
GEO Series GSE122705. Arabidopsis thaliana. 24 samples. Type: Expression profiling by array.
Arabidopsis thaliana KO1 and KO3 deletion lines of the selective autophagy receptor AtNBR1
GEO Series GSE147124. Arabidopsis thaliana. 17 samples. Type: Expression profiling by array.
Arabidopsis thaliana KO1 and KO3 deletion lines of the selective autophagy receptor AtNBR1 - roots and shoots
GEO Series GSE169472. Arabidopsis thaliana. 35 samples. Type: Expression profiling by array.
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