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Dataset results
11 results for “seminal extracellular vesicles”
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
<p>Seminal extracellular vesicles (EVs) contain different subgroups that have diverse effects on sperm function. However, the effect of seminal EVs—especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H), medium density EV (EV-M), and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In EV-H-treated endometrial cells, we identified 1274 differentially expressed genes (DEGs). DEGs were enriched in cell adhesion and AKT, STAT3 pathways. Therefore, we illustrated that EV-H enhanced the adhesion of human choriocarcinoma JAr cell spheroids to endometrial cells through the LIF-STAT3 pathway. Collectively, our findings indicated that seminal EV-H could regulate endometrial receptivity through the LIF pathway, which would provide novel insights into male fertility.</p>
Reassessment of the proteomic composition and function of extracellular vesicles in the seminal plasma
<p>Seminal plasma contains a high concentration of extracellular vesicles (EVs). The heterogeneity of small EVs or the presence of non-vesicular extracellular matter(NV) pose major obstacles in understanding the composition and function of seminal EVs. In this study, we employed high-resolution density gradient fractionation to accurately characterize the composition and function of seminal EVs and NV. We found that the seminal EVs could be divided into three different subtypes, namely high-density EV (EV-H), medium-density EV (EV-M), and low-density EV (EV-L) after purification using iodixanol,while NV was successfully isolated. EVs and NV display different features in size, shape and expression of some classic exosome markers. Both EV-H and NV could markedly promote sperm motility and capacitation compared with EV-M and EV-L, whereas only the NV fraction induced sperm acrosome reaction. Proteomic analysis results showed that EV-H, EV-M, EV-L, and NV had different protein components and were involved in different physiological functions. Further study showed that EV-M might reduce the production of sperm intrinsic reactive oxygen species (ROS) through Glutathione S-transferase Mu 2 (GSTM2).This study provides novel insights into important aspects of seminal EVs constituents and sounder footing to explore their functional properties in male fertility.</p>
Reassessment of the proteomic composition and function of extracellular vesicles in the seminal plasma
Open the record for dataset details and reuse information.
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Open the record for dataset details and reuse information.
Altered non-coding RNA profiles of seminal plasma extracellular vesicles of men with poor semen quality undergoing In Vitro fertilization treatment
GEO Series GSE203494. Homo sapiens. 96 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The whole transcriptome analysis for seminal plasma extracellular vesicles (SPEVs) of Yorkshire boars
GEO Series GSE216966. Sus scrofa. 48 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Lipidomic profile of two differently-sized subsets of porcine seminal extracellular vesicles
<p>Raw data (.CDF) from the lipidomic analysis of two differently-sized subsets (small and large) of seminal extracellular vesicles (sEVs) isolated from porcine seminal plasma. The procedure used for sEV isolation combined serial centrifugations, ultrafiltration and size-exclusion chromatography. High performance liquid chromatography-high resolution mass spectrometry was used for lipidomic analysis.</p>
Seminal Plasma and Extracellular Vesicles of Aged Male Mouse affects Early embryo Implantation via immunomodulation
GEO Series GSE180444. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Seminal extracellular vesicle sncRNA profiles reveal miRNAs/isomiRs as predictive biomarkers of testicular sperm retrieval outcome in azoospermic patients
GEO Series GSE217716. Homo sapiens. 17 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tra
GEO Series GSE152714. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Identification of specific miRNAs in the seminal plasma extracellular vesicles from fertile and subfertile rabbit bucks
GEO Series GSE209607. Oryctolagus cuniculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.