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ShareScore release 0.9.0
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9 results for “serial passage”
Data from: Phenotypic shift in Wolbachia virulence towards its native host across serial horizontal passages
Vertical transmission mode is predicted to decrease the virulence of symbionts. However, Wolbachia, a widespread vertically transmitted endosymbiont, exhibits both negative and beneficial effects on arthropod fitness. This 'Jekyll and Hyde' behaviour, as well as its ability to live transiently outside host cells and to establish new infections via horizontal transmission, may reflect the capacity of Wolbachia to exhibit various phenotypes depending on the prevailing environmental constraints. To study the ability of Wolbachia to readily cope with new constraints, we forced this endosymbiont to spread only via horizontal transmission. To achieve this, we performed serial horizontal transfers of haemolymph from Wolbachia-infected to naive individuals of the isopod Armadillidium vulgare. Across passages, we observed phenotypic changes in the symbiotic relationship: (i) The Wolbachia titre increased in both haemolymph and nerve cord but remained stable in ovaries; (ii) Wolbachia infection was benign at the beginning of the experiment, but highly virulent, killing most hosts after only a few passages. Such a phenotypic shift after recurrent horizontal passages demonstrates that Wolbachia can rapidly change its virulence when facing new environmental constraints. We thoroughly discuss the potential mechanism(s) underlying this phenotypic change, which are likely to be crucial for the ongoing radiation of Wolbachia in arthropods.
Data from: Phenotypic shift in Wolbachia virulence towards its native host across serial horizontal passages
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Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors.
GEO Series GSE61228. Homo sapiens. 8 samples. Type: Expression profiling by array.
Longitudinal DNA methylation in serially passaged primary and modified human astrocytes
GEO Series GSE226079. Homo sapiens. 70 samples. Type: Methylation profiling by genome tiling array.
A small molecule modulator of prion protein enhances proliferation and engraftment of mesenchymal stem cells and extends their lifespan upon serial passage in culture
GEO Series GSE31205. Homo sapiens. 12 samples. Type: Expression profiling by array.
Generation and Characterization of Lung Cancer PDX Models from Human Specimens Across Serial Passages
GEO Series GSE295073. Mus musculus; Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Global Transcription Profiling and Virulence Potential of Streptococcus pneumoniae after Serial Passage
GEO Series GSE12607. Streptococcus pneumoniae TIGR4; Streptococcus pneumoniae G54; Streptococcus pneumoniae; Streptococcus pneumoniae R6. 4 samples. Type: Expression profiling by array.
Longitudinal DNA methylation in serially passaged BJ Fibroblasts to investigate the latent aging of cells
GEO Series GSE268145. Homo sapiens. 66 samples. Type: Methylation profiling by genome tiling array.
A gene-expression oligo microarray for two serial passages of Ichthyophthirius multifiliis
GEO Series GSE22466. Ichthyophthirius multifiliis. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.