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115 results for “sertoli cell”
Case report: Large-cell calcifying Sertoli cell tumor
<p><strong>Case history</strong></p> <p>21-year-old male with a painless mass in the right testicle and a prior history of cutaneous lesions.</p> <p> </p> <p><strong>Histologic findings</strong></p> <p>Figures show a proliferation composed of large, polygonal cells with ample, eosinophilic cytoplasm, round nuclei, evident nucleoli, with a trabecular, cord-like pattern of growth, associated with foci of dystrophic calcification and psammomatous bodies, within a myxoid loose stroma.</p> <p> </p> <p><strong>Discussion</strong></p> <p>Large-cell calcifying Sertoli cell tumor is an unusual morphological variant of Sertoli cell tumors composed of large polygonal Sertoli cells associated with calcification. Around one third of all cases appear in patients with the Carney or, less frequently, with the Peutz-Jeghers syndrome.</p> <p>Clinically, it presents as a small (<2 cm), painless testicular mass, which can be bilateral and multifocal in about 40% of the cases, especially in syndromic settings. In non-sporadic cases extratesticular manifestations are related to the associated syndrome, such as myxomas of the skin, soft-tissue, and heart and myxoid lesions of the breast, facial lentigines, cutaneous blue nevi, secondary Cushing syndrome due to pigmented adrenocortical nodular hyperplasia, pituitary somatotroph adenomas, and psammomatous melanotic schwannomas.</p> <p>Microscopically, solid, tubular, and cord-like growth patterns can be observed. Tumor cells are large polygonal with abundant eosinophilic, finely granular cytoplasm, vesicular nuclei with prominent nucleoli, within a myxohyaline stroma. Distinct calcifications characterized by large, laminated calcified nodule, psammoma bodies and focal ossification, and neutrophilic infiltration, can be also found.</p> <p>The presence of large tumor size (>4 cm), overt nuclear atypias, increased mitotic activity (>3 mitosis/10 HPF), necrosis, extratesticular extension, and vascular invasion are associated with clinical aggressive behavior. Malignant tumors appear in patients older than 25 years old and are usually not associated with syndromes.</p> <p>Tumor cells are positive for vimentin, S-100, EMA, melan-A, desmin, and inhibin, and focally positive for cytokeratins. The main differential diagnoses of large-cell calcifying Sertoli cell tumor include Sertoli cell and Leydig cell tumors.</p> <p>Most of the cases behave indolently, and surgical excision is the treatment of choice.</p>
Effects of titanium dioxide nanoparticles on porcine pre-pubertal sertoli cells
<p>This dataset contains data from an <em>in vitro</em> experiment described in the paper: "Mancuso F, Arato I, Di Michele A, Antognelli C, Angelini L, Bellucci C, Lilli C, Boncompagni S, Fusella A, Bartolini D, Russo C, Moretti M, Nocchetti M, Gambelunghe A, Muzi G, Baroni T, Giovagnoli S, Luca G. Effects of Titanium Dioxide Nanoparticles on Porcine Prepubertal Sertoli Cells: An "In Vitro" Study. Front Endocrinol (Lausanne). 2022 Jan 3;12:751915. doi: 10.3389/fendo.2021.751915. PMID: 35046890; PMCID: PMC87623342".</p> <p>The data describes the X-ray diffraction (XRD), scanning electron microscopy (SEM) analysis to confirm the correct synthesis of titanium dioxide<sub> </sub>nanoparticles (TiO<sub>2</sub> NPs), and the transmission electron microscopy (TEM) analysis to investigate the morphological/ultrastructural effects on porcine pre-pubertal Sertoli cells (SCs), after an acute (24 hours) and chronic (from 1 up to 3 weeks) exposure, at both sub-toxic (5 µg/ml) and toxic (100 µg/ml) doses of TiO<sub>2</sub> NPs.</p> <p>The diffractogram confirmed the correct synthesis of TiO2 NPs in accordance with the International Centre for Diffraction Data Sample (JCPDS 00-001-0562) and the asterisk (*) represents the peaks of TiO<sub> </sub>NPs in anatase form; SEM analysis showed that the mean size distribution of TiO<sub>2</sub> NPs in dry form was 20 ± 5 nm and confirmed that TiO<sub>2</sub> NPs tend to form aggregates of submicrometric dimensions;</p> <p>Representative TEM images of unexposed SCs showed elongated oval or spindle-shaped SCs containing quite large nuclei (N) and abundant mitochondria. SCs did not show substantial and/or severe ultrastructural alterations in SCs treated with 5 µg/ml TiO2 NPs for 1 and 2 weeks, in all the other exposure conditions (5 µg/ml for 3 weeks and 100 µg/ml for 1, 2, and 3 weeks), SCs showed several ultrastructural changes with a high percentage of severely damaged SCs, presenting different features of cell stress such as deeply invaginated and shrunk nuclei, disorder/ marginalization of chromatin components, swollen very fragmented, or almost completely missing endoplasmic reticulum membranes. In addition, mitochondrial morphology was severely affected and mitochondria number dramatically decreased with the presence of several large vacuoles, probably as a result of apoptotic mitochondria and/or enlarged endoplasmic reticulum and/or increased frequency of lipid droplets.</p> <p>The main results of the experiments are that long time constant exposure of SCs at both TiO<sub>2</sub> NPs concentrations inevitably led to an altered ultrastructure.</p>
Effects of titanium dioxide nanoparticles on porcine pre-pubertal sertoli cells
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Data for: Mouse sperm DNA-methylation changes induced by age and mechanistic target of rapamycin (mTOR) manipulation in Sertoli cells
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miR-1285-3p targets TPI1 to regulate the glycolysis metabolism signaling pathway of Tibetan sheep Sertoli cells
<p><span>Glycolysis in sertoli cells (SCs) can provide energy substrates for the development of spermatogenic cells. Triose phosphate isomerase 1 (TPI1) is one of the key catalytic enzymes involved in glycolysis. However, the biological function of TPI1 in SCs and its role in glycolytic metabolic pathways are poorly understood. On the basis of previous research, we isolated primary SCs from Tibetan sheep and overexpressed <em>TPI1</em> gene to determine its effect on the proliferation, glycolysis, and apoptosis of SCs. Secondly, we investigated the relationship between <em>TPI1</em> and miR-1285-3p, and whether miR-1285-3p regulates the proliferation and apoptosis of SCs, and participates in glycolysis by targeting <em>TPI1</em>. Results showed that overexpression of <em>TPI1</em> increased the proliferation rate and decreased apoptosis of SCs. In addition, overexpression of <em>TPI1</em> altered glycolysis and metabolism signaling pathways and significantly increased the amount of the final product lactic acid. Further analysis showed that miR-1285-3p inhibited <em>TPI1</em> by directly targeting its 3'untranslated region. Overexpression of miR-1285-3p suppressed the proliferation of SCs, and this effect was partially reversed by restoration of <em>TPI1</em> expression. In summary, this study shows that the miR-1285-3p/TPI1 axis regulates glycolysis in SCs. These findings add to our understanding of the regulation of spermatogenesis in sheep and other mammals.</span></p>
miR-1285-3p targets TPI1 to regulate the glycolysis metabolism signaling pathway of Tibetan sheep Sertoli cells
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The tumor suppressor PTEN regulates negatively Sertoli cell proliferation, testis size and sperm production in vivo
GEO Series GSE123119. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Ptbp1 facilitates cytoskeletal organization through the mTOR-PKCα pathway in Sertoli cells thereby supporting spermatogenesis
GEO Series GSE295053. Mus musculus. 12 samples. Type: Other; Expression profiling by high throughput sequencing.
RNA-Seq of UXT KO in Primary Sertoli cells
GEO Series GSE155412. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Role of retinoblastoma protein (Rb) in mouse Sertoli cells function
GEO Series GSE22234. Mus musculus. 12 samples. Type: Expression profiling by array.
P6 Mouse Sertoli Cell Small RNA seq
GEO Series GSE40692. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Dataset of differentially expressed genes in mouse P12 testes in response to the loss of ATRX in Sertoli cells
GEO Series GSE195572. Mus musculus. 6 samples. Type: Expression profiling by array.
Genome-wide expression microarray analysis of romidpesin treated GCC cell lines, fibroblasts and Sertoli cells.
GEO Series GSE71239. Homo sapiens. 28 samples. Type: Expression profiling by array.
Stage-dependent gene expression change in Sertoli cells regulated by retinoic acid signaling
GEO Series GSE34758. Mus musculus. 34 samples. Type: Expression profiling by array.
Investigation of the Regulatory Mechanism of Dhx37 in Sertoli Cells Using snRNA-seq
GEO Series GSE309389. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of ovarian Sertoli-Leydig cell tumors
GEO Series GSE71160. Homo sapiens. 8 samples. Type: Expression profiling by array.
Comparison of gene expression between MEFs and induced embryonic Sertoli-like cells
GEO Series GSE39650. Mus musculus. 10 samples. Type: Expression profiling by array.
Comparison of gene expression between MEFs, MEFs (NWD), immature Sertoli cells and mature Sertoli cells
GEO Series GSE39649. Mus musculus. 8 samples. Type: Expression profiling by array.
Effects of xenogeneic complement 90-minute exposure on neonatal porcine Sertoli cells (NPSC).
GEO Series GSE221711. Sus scrofa. 6 samples. Type: Expression profiling by high throughput sequencing.
PTBP1 mediates Sertoli cell actin cytoskeleton organization through regulating alternative splicing of actin regulators
GEO Series GSE267924. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.