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120 results for “signal attenuation”
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis "
<table> <tbody> <tr> <td> <p>Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix (ECM) deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive ECM production in IPF. Here we report that fibrotic AT2 cells regulate production and crosslinking of ECM via the co-transcriptional activator YAP. YAP leads to increase expression of Lysyloxidase (LOX) and subsequent LOX mediated crosslinking by fibrotic AT2 cells. Pharmacological YAP inhibition reverses fibrotic AT2 cell reprogramming and LOX expression in experimental lung fibrosis <span>in vivo</span><span> and in human fibrotic </span><span>tissue ex vivo</span><span>. We thus identify YAP-TEAD/LOX inhibition in AT2 cells as a promising potential new therapy for IPF patients.<span> </span></span></p> <p><span><span>In</span></span></p> </td> </tr> </tbody> </table>
Dataset of the analysis described in the article: EM signal penetration in a planetary soil simulant: Estimated attenuation rates using GPR and TDR in volcanic deposits on Mount Etna
<p>GPR and TDR Data collected at two sites on Mount Etna.</p> <p>See for more details the article</p>
Intrinsic TGF-b Signaling Attenuates Proximal Tubule Mitochondrial Injury and Inflammation in Chronic Kidney Disease
<p>Bulk RNA sequencing processed count files for the article titled "Intrinsic TGF-b Signaling Attenuates Proximal Tubule Mitochondrial Injury and Inflammation in Chronic Kidney Disease", by Nlandu Khodo et al., in review. </p> <p>Corresponding GEO submission can be found here: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225545 </p>
Seismic attenuation extraction from traffic signals recorded by a single seismic station (2/3)
<p>This repository contains the raw field data and corresponding codes for the West Coast Highway site in the manuscript entitled "Seismic attenuation extraction from traffic signals recorded by a single seismic station " by Yumin Zhao, Enhedelihai Nilot, Bei Li, Yunyue Elita Li, and Gang Fang. </p>
Seismic attenuation extraction from traffic signals recorded by a single seismic station (1/3)
<p>This repository contains the raw field data and corresponding codes for the NUS exit site in the manuscript entitled "Seismic attenuation extraction from traffic signals recorded by a single seismic station " by Yumin Zhao, Enhedelihai Nilot, Bei Li, Yunyue Elita Li, and Gang Fang. </p>
Fig. 7 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 7. Experimental validation of the representative signaling pathways in vitro. Compound 19 inhibited the NF-kB (A) and JAK2/STAT3 (B) signaling pathways in RAW 264.7 cells induced by LPS. #p <0.05 compared with control group. *p <0.05, **p <0.01 compared with model group.
Fig. 6 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 6. (A) The gene ontology (GO) enrichment analysis for potential targets. (B) The KEGG pathway enrichment analysis of potential targets. (C) The drugcompound-target-pathway (D-C-T-P) network established by Cytoscape V 3.6.0. The red node represents K. coccinea, the yellow represents active compounds, the blue nodes represent targets, and the green nodes represent the pathways. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 5. The networks of sesquiterpenoid compounds of K. coccinea in treating rheumatoid arthritis. (A) The drug-compound-target (D-C-T) network of K. coccinea. The red node represents K. coccinea, the yellow represents active compounds, and the blue nodes represent targets. (B) The protein-protein interaction (PPI) network of protein targets obtained from the STRING database and visualized by Cytoscape V 3.6.0. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway
ClinicalTrials.gov study NCT00755729. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fig. 3 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 3. Key ROESY correlations of compounds 1and 2.
Fig. 1 in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 1. Structures of compounds 1–20 from K. coccinea.
Fig. 2. Key 1H–1H in Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways
Fig. 2. Key 1H–1H COSY and HMBC correlations of compounds 1and 2.
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling
GEO Series GSE261919. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models
GEO Series GSE180085. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inhibition of histone acetyltransferase attenuates 3D chromatin-mediated insulin signaling in pancreatic cancer (Hi-C dataset)
GEO Series GSE197293. Homo sapiens. 8 samples. Type: Other.
Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment
GEO Series GSE104507. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of endothelial Notch signaling attenuates inflammation [ChIP-Seq]
GEO Series GSE87552. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-sequencing reveals signaling pathways associated with tumor invasion and epithelial–mesenchymal transition in HIPK2-attenuated cells
GEO Series GSE158262. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Hydrogen gas therapy attenuate inflammatory pathway signaling in septic mice
GEO Series GSE152527. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
BTLA and PD-1 signals attenuate TCR-mediated gene expression
GEO Series GSE239586. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.