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Dataset results
31 results for “smoothened”
Simulations for: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
<p><strong>Atomistic simulations of Smoothened:</strong></p> <p>Atomistic molecular dynamics simulations of glycosylated mouse Smoothened (mSMO) and human Smoothened (hSMO) in distinct liganded states:</p> <p>- mSMO in an apo state (mSMO_apo)</p> <p>- mSMO with TMD cholesterol bound (mSMO_chol_TMD)</p> <p>- mSMO with CRD cholesterol bound (mSMO_chol_CRD)</p> <p>- mSMO with cholesterol bound to the CRD and TMD (mSMO_2chol_TMD_CRD)</p> <p>- mSMO bound to CRD cholesterol and Smoothened agonist (SAG) (mSMO_chol_CRD_SAG)</p> <p>- mSMO bound to CRD and TMD cholesterols, SAG and an intracellular nanobody (mSMO_2chol_SAG_nanobody)</p> <p>- mSMO bound to CRD and TMD cholesterol and with an additional cholesterol bound at a proposed 'mid' position (mSMO_3chol)</p> <p>- hSMO bound to CRD cholesterol and SAG (hSMO_chol_CRD_SAG)</p> <p> </p> <p>All simulations were run for 5x 300 ns. The active mSMO conformation was obtained from the Protein Data Bank (PDB ID: 6O3C). The hSMO structure was determined using X-ray crystallography as outlined within this study. </p> <p><strong>File description for each system:</strong></p> <p>- md_fit_firstframe.pdb : Initial frame used for atomistic simulations (replicate 1, each replicate equilibrated independently). </p> <p>- md_fit_<em>X</em>.xtc : Gromacs trajectory file for each replicate (X=replicate number). </p>
Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors
ClinicalTrials.gov study NCT01529450. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Binding position dependent modulation of smoothened activity by Cyclopamine
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Multiple modes of cholesterol translocation in the human Smoothened receptor
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RNA-seq data for an embryonic chicken digit tissue time-series, treated in vivo with smoothened agonist to induce ectopic feathers
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Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)
ClinicalTrials.gov study NCT06357988. IPD Sharing: YES. Countries: 1. Publications: 0.
Phase 2 Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923)
ClinicalTrials.gov study NCT01357655. IPD Sharing: Not stated. Countries: 8. Publications: 0.
Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)
ClinicalTrials.gov study NCT01218477. IPD Sharing: Not stated. Countries: 7. Publications: 0.
An essential role for the Gai2 protein in Smoothened-stimulated mammary epithelial cell proliferation
GEO Series GSE70210. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease [RNA-Seq]
GEO Series GSE213621. Homo sapiens. 368 samples. Type: Expression profiling by high throughput sequencing.
Targeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
GEO Series GSE19657. Mus musculus. 27 samples. Type: Expression profiling by array; Genome variation profiling by genome tiling array.
Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies [RNA-seq]
GEO Series GSE266389. Homo sapiens; Mus musculus. 60 samples. Type: Expression profiling by high throughput sequencing.
Overlap in signaling between constitutively active forms of Smoothened and the α subunit of the heterotrimeric G protein G13
GEO Series GSE111669. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Hedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth
GEO Series GSE44581. Homo sapiens. 8 samples. Type: Expression profiling by array.
Overlap in Signaling through Smoothened and the Heterotrimeric G Protein G13
GEO Series GSE98841. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease
GEO Series GSE213623. Mus musculus; Homo sapiens. 372 samples. Type: Expression profiling by high throughput sequencing.
PTEN heterozygosity promotes tumorigenesis in a Smoothened active mouse model of medulloblastoma
GEO Series GSE19059. Mus musculus. 12 samples. Type: Expression profiling by array.
Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease [scRNA-Seq]
GEO Series GSE213183. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing of Smoothened Agonist (SAG)- versus solvent-treated (DMSO) TtT/GF cells
GEO Series GSE153550. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies
GEO Series GSE266391. Homo sapiens; Mus musculus. 74 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.