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30 results for “social defeat”
Transcriptome data of social defeat stress of various durations
<p>Data of meta-analysis of transcriptomic changes in the PFC after SDS of various durations. This analysis enabled us to identify clusters of the most reproducible changes in gene expression after 10 and 30 days of SDS and to determine which genes are associated with susceptibility and resistance to SDS after 10 days. Furthermore, we compared such changes in mice after SDS of various durations with data from a meta-analysis of postmortem transcriptomes of the dorsolateral PFC from depressed patients and data of the transcriptomic study on the PFC from patients with PTSD.</p>
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling: single cell RNA sequencing data
<p>Meningeal single cell RNA sequencing data</p> <p>Meningeal samples were collected from both dorsal and ventral skull, avoiding inclusion of choroid plexus. Samples were digested in 2.5 mg/mL Collagenase D (Cat. #11088858001; Roche) and 12.5 μL of 0.5 mg/mL DNAseI (Cat. #L5002139; Worthington), put on a shaker at 370C for 30 m, diluted with cold HBSS + 0.1% BSA, and mashed through a 70 μm cell strainer prior to sorting.</p> <p>Data represent live, nucleated, singlet cells (DAPI-DRAQ5+) sorted on a BD FACS Aria Fusion into HBSS + 10% FBS prior to droplet encapsulation using 10x Genomics’ Drop-seq platform (Chromium v2).</p> <p>10X chip lane is indicate by 'group' column</p> <p>Group 1 = 4 pooled homecage control (unstressed) mice</p> <p>Group 2 = 4 pooled homecage control (unstressed) mice</p> <p>Group 3 = 4 pooled mice exposed to chronic social defeat for 14 days; tissue was collected 2 hours following final defeat</p> <p>See the following repositories for data processing:</p> <p><a href="https://github.com/maryellenlynall/2019_bcell_stress/blob/master/bcellstress20.Rmd">https://github.com/maryellenlynall/2019_bcell_stress/</a> (processing from raw files starts at bcellstress020.Rmd)</p> <p><a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a></p> <p>We also provide a processed dataset (processed.RData) with assays 'counts' and 'logcounts' which is the processed single cell object saved at line "# Save object for upload to Zenodo" in script <a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a>neutrophilstress01.Rmd </p> <p>Cluster annotations are in sce$Annotation</p> <p>Neutrophil subcluster annotations are in sce$Subcluster</p> <p>Sample condition is in sce$cond, where "HC" indicates homecage control and "SD" indicates chronic social defeat</p> <p>10X chip lane is in sce$group</p>
Gene expression analysis of mouse brain regions after chronic social defeat stress (CSDS)
GEO Series GSE109315. Mus musculus. 88 samples. Type: Expression profiling by high throughput sequencing.
Sequencing to determine the effect of neuronal IL-1b receptor knockout on the stress effect of paired fighting social defeat in mice
GEO Series GSE149195. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Global Patterns of Gene Expression Associated with Vulnerability and Resilience to Social Defeat
GEO Series GSE8870. Mus musculus. 18 samples. Type: Expression profiling by array.
Effect of propranolol on differential gene expression in peripheral blood monocytes from mice subject to repeated social defeat
GEO Series GSE47153. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression analysis of mouse BNST and blood cells after chronic social defeat stress (CSDS)
GEO Series GSE122840. Mus musculus. 77 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
GEO Series GSE210577. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Expression data from mouse meninges - home cage (HC) and chronic social defeat (SD) stress mice
GEO Series GSE275966. Mus musculus. 14 samples. Type: Expression profiling by array.
Differential gene expression in peripheral blood leukocytes from mice subject to repeated social defeat
GEO Series GSE47154. Mus musculus. 12 samples. Type: Expression profiling by array.
Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in microglia or whole medial prefrontal cortex
GEO Series GSE115996. Mus musculus. 40 samples. Type: Expression profiling by array.
Effect of chronic social defeat stress (CSDS) on gene expression in wild-type mice and in Neurensin-2 knockout mice.
GEO Series GSE274515. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
The Effect of Adolescent Environmental Enrichment and Social Defeat on the Nucleus Accumbens and Hippocampus in a Selectively Bred Model with Anxious Phenotype (bLR Rats): RNAseq data
GEO Series GSE237890. Rattus norvegicus. 80 samples. Type: Expression profiling by high throughput sequencing.
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in males
GEO Series GSE301684. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Gender specific transcription regulation in the prefrontal cortex following social defeat stress
GEO Series GSE146845. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation profiling of germ cells from mice exposed to chronic social defeat stress
GEO Series GSE288729. Mus musculus. 6 samples. Type: Methylation profiling by high throughput sequencing.
Microglial RNA-sequencing after stress-sensitization by repeated social defeat
GEO Series GSE124169. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
NG2 glia-derived GABA release tunes inhibitory synapses and contributes to anxiety-like behavior in chronic social defeat stress
GEO Series GSE162049. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of microglia isolated from the mPFC or NAc without or with repeated social defeat stress (R-SDS)
GEO Series GSE115995. Mus musculus. 26 samples. Type: Expression profiling by array.
Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in the medial prefrontal cortex (mPFC)
GEO Series GSE115994. Mus musculus. 14 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.