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93 results for “soleus”
Four lipidomics datasets (mouse liver, mouse pancreatic islets, mouse soleus muscle and mouse visceral adipose tissue), generated for the publication Mehl et al., "A multiorgan map of metabolic, signalling, and inflammatory pathways that coordinately control fasting glycemia in mice"
<p>Mehl, Thorens et al present a multiomics study aimiing to<span> identify the pathways that are coordinately regulated in pancreatic </span><span>b</span><span>-cells, muscle, liver, and fat to control fasting glycemia we fed C57Bl/6, DBA/2 and Balb/c mice a regular chow or a high fat diet for 3, 10 and 30 days. We measured fasted glycemia, insulinemia and whole-body insulin resistance. Transcriptomic and lipidomic analysis were used in a data fusion approach to identify organ-specific pathways related to the glycemic levels across all conditions investigated. In pancreatic islets, constant insulinemia despite higher glycemic levels were associated with reduced expression of mRNAs encoding hormone and neurotransmitter receptors as well as OXPHOS, cadherins, integrins and gap junction proteins. Higher glycemia and whole-body insulin resistance were associated, in muscle, with reduced expression of mRNAs encoding insulin signaling proteins and enzymes of the glycolysis, Krebs’ cycle and OXPHOS pathways, as well as endocytosis and exocytosis proteins; in hepatocytes, with lower expression of mRNAs of the insulin signaling pathway, of branched chain amino acid catabolism and of OXPHOS; in adipose tissue, with increased expression of mRNAs of innate immunity and lipid catabolism. These data provide a map of the pathways that are coordinately recruited in the investigated tissues to control fasting glycemia and a resource for further studies of interorgan communication in glucose homeostasis. </span></p>
Data from: Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
The force produced by muscles varies with muscle length. Compared to isometric contractions at the same final length, force increases after lengthening, known as force enhancement, and decreases after shortening, known as force depression. The mechanisms of force enhancement remain unexplained by the sliding-filament and cross-bridge theories of muscle contraction. Although cross-bridge mechanisms have been proposed to account for force depression, so too have other mechanisms. In addition to cross bridges, titin has been suggested to contribute to both force enhancement and depression. Although titin is too compliant in passive muscles to contribute to active stiffness, recent evidence suggests that calcium activation increases titin stiffness. To test the hypothesis that titin plays a role in force enhancement and depression, we investigated muscle force in active and passive wild type and mdm soleus muscles after isovelocity stretching and shortening at three activation levels. Muscles from mdm mice (muscular dystrophy with myositis) have a predicted 83 amino acid deletion in the N2A region of titin and show no increase in stiffness when activated. We found that: 1) force enhancement and depression were reduced in mdm soleus compared to wild type muscles; 2) force enhancement increased with the amplitude of stretch across all activation levels in wild type and mdm muscles, while force depression increased with amplitude in wild type but not in mdm muscles; and 3) maximal shortening velocity of wild type and mdm muscles was similar, although active stress was reduced in mdm compared to wild type muscles. The results of this study suggest a role for titin in force enhancement and depression, which contribute importantly to regulation of muscle force during natural movements.
Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after three-day dry immersion
<p>Supplemental Tables for a study <strong>Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after three-day dry immersion</strong></p>
Data from: Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
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Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice
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SBF-SEM Dataset of Guinea Pig Adult Soleus
<p>Multiple SBF-SEM datasets from 3 Duncan hartley guinea pig adult soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness. </p>
SBF-SEM Dataset of Guinea Pig Fetal Day 55-59 Soleus Muscle
<p>Multiple SBF-SEM datasets of Duncan Hartley guinea pigs at fetal day 55-59 from soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness. </p>
SBF-SEM Dataset of Guinea Pig Fetal Day 60-64 Soleus Muscle
<p>Multiple SBF-SEM datasets from 3 Duncan hartley guinea pig fetal day 60-64 soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness. </p>
SBF-SEM Dataset of Guinea Pig Fetal Day 50-54 Soleus Muscle
<p>Multiple SBF-SEM datasets of Duncan Hartley guinea pigs at fetal day 50-54 from soleus muscle. Parameters for each of the datasets are attached as a spreadsheet, including nm resolution, image size, number of sections and section thickness. </p>
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
ClinicalTrials.gov study NCT05571033. IPD Sharing: YES. Countries: 1. Publications: 2.
Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis
ClinicalTrials.gov study NCT03119948. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Percutaneous Needle Electrolysis (PNE) in Soleus Injury
ClinicalTrials.gov study NCT04042012. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Moderate Intensity Soleus Push-ups vs Sustained Soleus Push-ups on Lipid Profile Among Young Population
ClinicalTrials.gov study NCT06326788. IPD Sharing: NO. Countries: 1. Publications: 5.
Supplementary information: Motor point stimulation activates fewer Ia-sensory nerves than peripheral nerve stimulation in human soleus muscle
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Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after three-day dry immersion
<p>Supplemental Figures for a study <strong>Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after three-day dry immersion</strong></p>
Unloading Induced Effects on Local Glucose Uptake Into m. Soleus
ClinicalTrials.gov study NCT02698878. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Soleus Loading Response During Walking
ClinicalTrials.gov study NCT05436366. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Whole Body Vibration Induced Muscle Activity and Effect of the Changes in Length of Soleus Muscle and Angle of Ankle
ClinicalTrials.gov study NCT02468011. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Global gene expression analysis highlights microgravity sensitive key genes in soleus and EDL of 30 days space flown mice
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological condition. The aim of this study was to investigate at both morphological and global gene expression level skeletal muscle adaptation to microgravity in mouse soleus and extensor digitorum longus (EDL). Adult male mice C57BL/N6 were flown aboard the BION-M1 biosatellite for 30 days on orbit (BF) or housed in a replicate flight habitat on Earth (BG) as reference flight control. In this study we investigated for the first time gene expression adaptation to 30 days of microgravity exposure in mouse soleus and EDL highlighting potential new targets for improvement of countermeasures able to ameliorate or even prevent microgravity-induced atrophy in future spaceflights. Overall Design: C57BL/N6 mice were randomly divided in 3 groups: Bion Flown (BF) mice flown aboard the Bion M1 biosatellite in microgravity environment for 30 days; Bion Ground (BG) mice housed in the same habitat of flown animals but exposed to earth gravity; and Flight Control (FC) mice housed in a standard animal facility.
Expression profiling of soleus muscle under the effect of simulated spaceflight
Spaceflight imposes the risk of skeletal muscle atrophy for astronauts. The understanding of muscle atrophy because of spaceflight is limited but continued efforts are essential for developing countermeasures of this effect. A distinct difference between spaceflight-induced muscle atrophy and other forms of atrophy is the additional effect of cosmic rays in outer space. To study spaceflight-induced muscle atrophy we performed two ground-based models of microgravity in a low dose radiation environment and studied transcriptional changes in rat soleus muscle using microarray technology.
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