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20 results for “spindle cell”
spindle cell variant diffuse large B-cell lymphoma (NGS annotation file; high confidence calls) hematolrep-2136295
<p>Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response.</p> <p>Carreras J, Kikuti YY, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Ito A, Nagase S, Miura H, Roncador G, Colomo L, Hamoudi R, Campo E, Nakamura N. Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma. <em>Hematology Reports</em>. 2023; 15(1):188-200. https://doi.org/10.3390/hematolrep15010020</p>
spindle cell variant diffuse large B-cell lymphoma (hematolrep-2136295)
<p>Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response.</p> <p>Carreras J, Kikuti YY, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Ito A, Nagase S, Miura H, Roncador G, Colomo L, Hamoudi R, Campo E, Nakamura N. Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma. <em>Hematology Reports</em>. 2023; 15(1):188-200. https://doi.org/10.3390/hematolrep15010020</p>
Data from: Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint
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E-cadherin in developing murine T cells controls spindle alignment and progression through β-selection
<p>Timelapse images of DN3a cells from E-cadherin<sup>flox/flox </sup>mice transfected with GFP (E-cad<sup>+</sup>) or GFP-cre (E-cad<sup>-</sup>) and cherry-ap2a2</p> <p> </p> <p>Extracted time points from additional movies which included dividing DN3a cells and analysed for asymmetric distribution of cherry-ap2a2 (alpha-adaptin) </p>
E-cadherin in developing murine T cells controls spindle alignment and progression through β-selection
<p>Confocal images of fixed DN3a cells </p> <p>Timelapse images of DN3a cells from E-cadherin<sup>flox/flox </sup>mice transfected with GFP (E-cad<sup>+</sup>) or GFP-cre (E-cad<sup>-</sup>) and cherry-tubulin</p>
Menin Associates with the Mitotic Spindle and is Important for Cell Division
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Detect genomic aberrations between PB1 and its counterpart, spindle-chromosome complex in human MII oocyte, PB2 and female pronucleus in human zygote at a single-cell level.
GEO Series GSE56676. Homo sapiens. 4 samples. Type: Genome variation profiling by genome tiling array.
A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells.
GEO Series GSE262149. Homo sapiens. 6 samples. Type: Other.
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
GEO Series GSE85969. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
GEO Series GSE22520. Mus musculus. 60 samples. Type: Expression profiling by array.
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell haemangioma in Ollier disease and Maffucci syndrome
GEO Series GSE30844. Homo sapiens. 55 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
Characterization of Rare Spindle and Root Cell Transcriptional Profiles in the Stria Vascularis of the Adult Mouse Cochlea
GEO Series GSE152551. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Heterogeneity of Progression in MYOD1-mutant spindle cell rhabdomyosarcoma
GEO Series GSE288065. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
single cell RNA-seq from bipolar spindle neuron (ENCSR225BBK)
GEO Series GSE78347. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
RAB11A and RAB11B redundantly regulate mitotic spindle function in dividing tissue progenitor cells
GEO Series GSE232493. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Spindle cell lesions with oncogenic EGFR kinase domain aberrations: expanding the spectrum of protein kinase-related mesenchymal tumors
GEO Series GSE261945. Homo sapiens. 14 samples. Type: Methylation profiling by array.
ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation
GEO Series GSE303898. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo
GEO Series GSE115204. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Knockout of Staufen1 impairs the localization of specific subsets of mRNAs on the mitotic spindle of colorectal cancer cells
GEO Series GSE138441. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Mouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
A series of conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma were generated and validated for relavence to corresponding human cancers.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.