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256 results for “sporadic”
Data from: Sporadic genetic connectivity among small insular populations of the rare geoendemic plant Caulanthus amplexicaulis var. barbarae (Santa Barbara Jewelflower)
Globally, a small number of plants have adapted to terrestrial outcroppings of serpentine geology, which are characterized by soils with low levels of essential mineral nutrients (N, P, K, Ca, Mo) and toxic levels of heavy metals (Ni, Cr, Co). Paradoxically, many of these plants are restricted to this harsh environment. Caulanthus ampexlicaulis var. barbarae (Brassicaceae) is a rare annual plant that is strictly endemic to a small set of isolated serpentine outcrops in the coastal mountains of central California. The goals of the work presented here were to 1) determine the patterns of genetic connectivity among all known populations of Caulanthus ampexlicaulis var. barbarae, and 2) estimate contemporary effective population sizes (Ne), in order to inform ongoing genomic analyses of the evolutionary history of this taxon, and to provide a foundation upon which to model its future evolutionary potential and long-term viability in a changing environment. Eleven populations of this taxon were sampled, and population-genetic parameters were estimated using 11 nuclear microsatellite markers. Contemporary effective population sizes were estimated using multiple methods and found to be strikingly small (typically Ne < 10). Further, our data showed that a substantial component of genetic connectivity of this taxon is not at equilibrium, and instead showed sporadic gene flow. Several lines of evidence indicate that gene flow between isolated populations is maintained through long-distance seed dispersal (e.g. > 1 km), possibly via zoochory.
Short tandem repeat expansions in LRP12 are absent in familial and sporadic amyotrophic lateral sclerosis patients of European ancestry
<p>In patients of Asian ancestry, a heterozygous CGG repeat expansion of >100 units in <i>LRP12</i> is the cause of oculopharyngodistal myopathy type 1 (OPDM1), and has been associated with amyotrophic lateral sclerosis (ALS) when repeat lengths are between 61-100 units, although with unusually long disease duration and without significant upper motor neuron involvement. This study investigated if <i>LRP12</i> CGG tandem repeats were expanded in ALS patients of European ancestry. We screened whole-genome sequencing data from 608 sporadic ALS patients, 35 familial ALS probands, and 4,703 neurologically normal controls for the <i>LRP12</i> CGG expansion using ExpansionHunter v4. All individuals had <i>LRP12 </i>CGG repeat lengths between 3-25 units. Our results suggest that <i>LRP12 </i>CGG repeat expansions may only be present in ALS patients of Asian ancestry with atypical clinical presentations.</p>
Text-fig. 3. Cave deposits exposed in Section No. 2 and recorded paleomagnetic polarities. 1 – reworked deposits; 2 – clayey silt, light brown with abundant black dots, structureless; 3 – clayey silt to silty clay, brown, chaotically deposited; 4 – clayey silt, light brown, structureless; 5 – clayey silt, light brown, laminated; 6 – clayey silt to silty clay, brown, structureless; 7 – clayey silt to silty clay, light brown, structureless; 8 – clayey silt, brown with abundant white carbonate clasts; 9 – clayey sandy silt, brown with abundant lighter clayey fragments; 10 – clayey sandy silt, brown with sporadic lighter clayey fragments. Geomagnetic polarity scale: black (N) – normal polarities, white (R) – reversed polarities, grey – intermediate or uninterpretable polarities. For more details see text. in New Updated Results Of Paleomagnetic Dating Of Cave Deposits Exposed In Za Hájovnou Cave, Javoříčko Karst
Text-fig. 3. Cave deposits exposed in Section No. 2 and recorded paleomagnetic polarities. 1 – reworked deposits; 2 – clayey silt, light brown with abundant black dots, structureless; 3 – clayey silt to silty clay, brown, chaotically deposited; 4 – clayey silt, light brown, structureless; 5 – clayey silt, light brown, laminated; 6 – clayey silt to silty clay, brown, structureless; 7 – clayey silt to silty clay, light brown, structureless; 8 – clayey silt, brown with abundant white carbonate clasts; 9 – clayey sandy silt, brown with abundant lighter clayey fragments; 10 – clayey sandy silt, brown with sporadic lighter clayey fragments. Geomagnetic polarity scale: black (N) – normal polarities, white (R) – reversed polarities, grey – intermediate or uninterpretable polarities. For more details see text.
NCSRD-DS-5GDDoS: 5G Radio and Core metrics containing sporadic DDoS attacks
<p><strong>NCSRD-DS-5GDDos v3.0 Dataset</strong><br>===<br>NCSRD-DS-5GDDos is a comprehensive dataset recorded in a real-world 5G testbed that aligns with the 3GPP specifications. The dataset captures Distributed Denial of Service (DDoS) attacks initiated by malicious connected users (UEs). </p> <p>The setup comprises of 3 cells with a total of 9 UEs connected to the same core network. The 5G network is implemented by the Amarisoft Callbox Mini solution (cell 2), and we further employ a second cell using the Amarisoft Classic (cell 1 & 3), that also hosts the 5G core.</p> <p>The setup utilizes a broad set of UE devices comprising a set of smart phones (Huawei P40), microcomputers (Raspberry Pi 4 - Waveshare 5G Hat M2), industrial 5G routers (Industrial Waveshare 5G Router), a WiFi-6 mobile hotspot (DWR-2101 5G Wi-Fi 6 Mobile Hotspot) and a CPE box (Waveshare 5G CPE Box). All UEs are being operated by subsidiary hosts which are responsible for the traffic generation, occurring from scheduled communications times.</p> <p>All identifiers are artificially generated and do not represent or based on personal data. We identify each UE through its ‘imeisv’ ID, that corresponds to the device in use, due to vendor implementation, that uses the same IMSI for all UEs.</p> <p>This dataset captures attack data from a total of 5 malicious User Equipment (UE) devices that initiated various flooding attacks on a 5G network. Each record includes key identifiers such as the IMEISV (International Mobile Equipment Identity Software Version number) and IP address of the attacking UE, along with the device type. The file "summary_report.csv" summarizes this information. The traffic types used in the attacks include syn flooding, UDP flooding, ICMP flooding, DNS flooding, and GTP-U flooding. The benign users stream YouTube and Skype traffic.</p> <p>The dataset is recorded through the use of a data collector that interfaces with the 5G network and gathers data regarding UEs, gNBs and the Core Network. The data are recorded in an InfluxdB and pre-processed into three separate tabular .csv files for more efficient processing: “amari_ue_data.csv”, “enb_counters.csv” and “mme_counters.csv”. In this version, we use an Amarisoft Classic (cells 1 & 3, Core Network) and an Amarisoft Mini (cell 2) (more information on the products can be found in https://www.amarisoft.com/).</p> <p>The ”amari_ue_data.csv” provides information on the UEs regarding identification (“imeisv”, “5g_tmsi”, “rnti”), IP addressing, bearer information, cell information (“tac”, “ran_plmn”), and cell information (“ul_bitrate”, “dl_bitrate”, “cell_id”, retransmissions per user per cell “ul_retx” as well as aggregated bit rates for each cell).</p> <p>The ”enb_counters.csv” focuses on cell-level information, providing downlink and uplink bitrates, usage ratio per user, cpu load of the gNB.</p> <p>We provide separate files of ”amari_ue_data.csv” and ”enb_counters.csv” generated from each gNB (Amarisoft Classic and Mini).</p> <p>The “mme_counters.csv” provides information on the Non-Access Stratum (NAS) of the 5G Network and focuses on session status reports (e.g., number of PDU session establishments, paging, context setup. This part gives an overview of the connection management throughout the recording session, and provides information on features suggested by 3GPP for abnormal user behavior.</p> <p>We also provide a separate pre-processed dataset, that merges the two "amari_ue_data_*.csv" file, including labeling of the malicious/benign samples, and may be more flexible for interested data scientists.</p> <p>Please refer to README.txt for the features included in each file.</p> <p>If you use this dataset, please also cite the following papers:</p> <p>M. Christopoulou, A. Garos, A. Vekraki, D. Santorinaios, I. Koufos, S. Karamitsiani, G. Xilouris, M.-A. Kourtis, G. Gardikis, and P. Trakadas, “User Terminals as Attackers: An Open Dataset Analysis of DDoS Attacks in 5G Networks,” in Proc. 2024 IEEE Conf. Standards Commun. Netw. (CSCN), 2024, pp. 301–307, doi: 10.1109/CSCN63874.2024.10849694.</p> <p>G. Xylouris, A. Vekraki, M. Christopoulou, M. A. Kourtis, E. K. Markakis and P. Trakadas, "Advancing Predictive Security for Consumer Applications in Beyond 5G/6G Networks With Annotated Datasets," in IEEE Transactions on Consumer Electronics, doi: 10.1109/TCE.2025.3567151.</p>
dataset related to article: "PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease"
<ol> <li>ESTIMATING PRION CONCENTRATION IN THE OM OF SCJD MM1, MV2 AND VV2 PATIENTS BY MEANS OF QUANTITATIVE PMCA (QPMCA)</li> <li>EVALUATION OF THE BIOCHEMICAL PROPERTIES OF PMCA GENERATED PRODUCTS</li> <li>PMCA ANALYSIS OF SCJD BRAIN HOMOGENATES</li> <li>PMCA ANALYSIS OF SCJD OLFACTORY MUCOSA</li> <li>RT-QuIC ANALYSIS OF OM AND BH OF SCJD PATIENTS AND CONTROLS</li> <li>WESTERN BLOT ANALYSIS OF BRAIN HOMOGENATES</li> <li>STATISTICAL ANALYSIS</li> </ol>
Geospatial Analysis of Road Conditions and Hazardous Factors in Communities on Continuous vs. Sporadic Permafrost in Greenland
<p>Road conditions and hazardous factors were surveyed in two permafrost-affected communities of West Greenland, Ilulissat (underlain by continuous ice-rich permafrost) and Sisimiut (underlain by sporadic permafrost). Pavement damages, repairs, embankment structural elements, artificial drainage systems, water accumulations and preferential snow ploughing deposits were notably mapped and georeferenced in a geographic information system to form high-resolution spatial databases. In total, respectively 66 and 76 \% of the paved road networks of Ilulissat and Sisimiut were surveyed. Manual in-situ mapping took place in September 2020 and September 2021 in Ilulissat, while Global Navigation Satellite System (GNSS) equipment was used to map road conditions in Sisimiut in September 2020. The severity of the pavement damages was assessed according to the ASTM D 6433–07, Standard Practice for Roads and Parking Lots Pavement Condition Index Surveys, by ASTM International (2008). The drainage conditions were characterized following the recommendations in Cold Regions Pavement Engineering, by Doré, G. and Zubeck, H. K. (2009).</p> <p>This dataset comprises the geospatial layers of the road damage and hazard inventories created for the settlements of Ilulissat and Sisimiut. Each settlement’s inventory is provided in a ZIP-folder, containing the geospatial layers as geopackages and sorted following a thematic structure. Further information about each layer and its attributes can be found in the metadata PDF document.</p>
Data from: Sporadic genetic connectivity among small insular populations of the rare geoendemic plant Caulanthus amplexicaulis var. barbarae (Santa Barbara Jewelflower)
Open the record for dataset details and reuse information.
Dataset Case-control study: Risk factors for sporadic non-pregnancy related listeriosis in Germany, 2012-2013
<p>The dataset contains data of a nationwide age-frequency matched case-control study in Germany, 2012-2013, which was performed to identify underlying conditions and foods asscociated with sporadic listeriosis. It covers anonymous sociodemografic information, information on underlying conditions, and >60 food items. Data for control subjects were obtained from a population-based random telephone sample, which was generated according to the method by Gabler and Häder and considered telephone numbers not registered in telephone books.</p>
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
<p>Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells, and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N>170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a 9-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.</p>
Digisonde Data files used for JGR-Space Physics paper "A simplified method of true height analysis to estimate the real height of sporadic E layers"
<p>paper submitted for publication in JGR-Space Physics.</p> <p>Digisonde Data files used for analysis</p> <p> </p> <p>A simplified method of true height analysis to estimate the real height of sporadic E layers</p> <p> </p> <p>Christos Haldoupis</p> <p>Department of Physics, University of Crete, Heraklion, Greece</p> <p>Haris Haralambous</p> <p>Frederick University and Frederick Research Center, Nicosia, Cyprus</p> <p>Chris Meek</p> <p>Institute of Space and Atmospheric Studies, University of Saskatchewan, Saskatoon, SK, Canada</p>
GNSS and Digisonde sporadic-E maps produced by Air Force Institute of Technology
<p>Spatial maps of sporadic-E are produced by combining COSMIC-2 RO data with Digisonde measurements, using the <em>S<sub>4</sub></em>-based approach described by Carmona et al. (2022). Images from the TEC-based approach used in other studies are also included for reference. </p> <p> </p> <p>Carmona, R. A., Nava, O. A., Dao, E. V., & Emmons, D. J. (2022). A Comparison of Sporadic-E Occurrence Rates Using GPS Radio Occultation and Ionosonde Measurements. <em>Remote Sensing</em>, <em>14</em>(3), 581.</p> <p> </p>
The c-Abl inhibitor IkT-148009 therapeutically suppresses neurodegeneration in models of heritable and sporadic Parkinson's Disease
<p>Parkinson's Disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded a-synuclein, which is thought to play a critical role in the etiopathogenesis of the disease. Animal models of PD suggest that activation of the Abelson Tyrosine Kinase, or c-Abl, plays an essential role in the initiation and progression of a-synuclein pathology and initiates processes leading to the degeneration of dopaminergic and non-dopaminergic neurons. Given the essential role of c-Abl in the disease, a proprietary c-Abl inhibitor library was developed to identify potent, orally bioavailable c-Abl inhibitors capable of crossing the blood-brain barrier based on pre-defined characteristics, leading to the discovery of IkT-148009. IkT-148009 is a selective, potent, brain-penetrant c-Abl inhibitor with a favorable toxicology profile that was analyzed for therapeutic potential in animal models of slowly progressive, a-synuclein-dependent disease. In models of both inherited and sporadic Parkinson's disease in the mouse, IkT-148009 suppressed c-Abl activation to baseline and substantially protected neurons from degeneration when administered therapeutically by once daily oral gavage beginning four weeks after disease initiation. Recovery of normal behavioral function in diseased mice occurred within 8 weeks of initiating treatment and occurred concomitantly with a substantial reduction of a-synuclein pathology in the brain. These disease-modifying outcomes in mice suggest IkT-148009 has the potential to be a disease-modifying therapy in human disease.</p>
Data from: Sporadic sampling not climatic forcing drives observed early hominin diversity
The role of climate change in the origin and diversification of early hominins is hotly debated. Most accounts of early hominin evolution link observed fluctuations in species diversity to directional shifts in climate or periods of intense climatic instability. None of these hypotheses, however, have tested whether observed diversity patterns are distorted by variation in the quality of the hominin fossil record. Here, we present a detailed examination of early hominin diversity dynamics, including both taxic and phylogenetically corrected diversity estimates. Unlike past studies, we compare these estimates to sampling metrics for rock availability (hominin-, primate-, and mammal-bearing formations) and collection effort, in order to assess the geological and anthropogenic controls on the sampling of the early hominin fossil record. Taxic diversity, primate-bearing formations, and collection effort show strong positive correlations, demonstrating that observed patterns of early hominin taxic diversity can be explained by temporal heterogeneity in fossil sampling rather than genuine evolutionary processes. Peak taxic diversity at 1.9 million years ago (Ma) is a sampling artefact, reflecting merely maximal rock availability and collection effort. In contrast, phylogenetic diversity estimates imply peak diversity at 2.4 Ma and show little relation to sampling metrics. We find that apparent relationships between early hominin diversity and indicators of climatic instability are, in fact, driven largely by variation in suitable rock exposure and collection effort. Our results suggest that significant improvements in the quality of the fossil record are required before the role of climate in hominin evolution can be reliably determined.
Data for research titled by "Numerical investigation on the height and intensity variations of sporadic E layers at mid-latitude"
<p>These data from the GAIA model and Es layer model, including the horizontal neutral winds, electric fields, and simulated Fe<sup>+</sup> density. </p>
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer
ClinicalTrials.gov study NCT01130519. IPD Sharing: YES. Countries: 1. Publications: 4.
Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)
ClinicalTrials.gov study NCT00790400. IPD Sharing: Not stated. Countries: 11. Publications: 5.
Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus
ClinicalTrials.gov study NCT02539459. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome Inhibitor, Bortezomib (Velcade ), in Adults With Solid Tumors With a Focus on Hereditary or Sporadic, Locally Advanced o
ClinicalTrials.gov study NCT00923247. IPD Sharing: NO. Countries: 1. Publications: 4.
Everolimus Therapy in People With Birt-Hogg-Dube Syndrome (BHD)-Associated Kidney Cancer or Sporadic Chromophobe Renal Cancer
ClinicalTrials.gov study NCT02504892. IPD Sharing: Not stated. Countries: 1. Publications: 3.
An Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203
ClinicalTrials.gov study NCT02573467. IPD Sharing: Not stated. Countries: 10. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.