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65 results for “sporozoites”
Human single-cell TCR data from irradiated sporozoite trial
<p>This is the MiAIRR-compliant single-cell AIRR-seq data of the study "Clonal evolution and TCR specificity of the human<br> TFH cell response to Plasmodium falciparum CSP" by Wahl <em>et al.,</em> <em>Sci Immunol</em> 7:eabm9644 (2022). The study defines the clonal evolution and epitope specificity of the human cTFH cell response to Plasmodium falciparum CSP.</p>
Data files: Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures
<p>Scripts, preprocessed count matrices, single-cell data objects, and generated data (tables and .rds files) from the scRNA-seq analyses performed in <strong>“Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures".</strong></p> <p> </p>
Fig. 2 Infected R in Isolation of infectious Theileria parva sporozoites secreted by infected Rhipicephalus appendiculatus ticks into an in vitro tick feeding system
Fig. 2 Infected R. appendiculatus adult ticks feeding on a silicone membrane. a A representation of adult ticks attached to a silicone membrane. b Detection of tick salivary gland infected with T. parva via p104 PCR. Amplicons were visualized in 2% agarose gel
Fig. 5 in Isolation of infectious Theileria parva sporozoites secreted by infected Rhipicephalus appendiculatus ticks into an in vitro tick feeding system
Fig. 5 Determination of the minimum dose of T. parva sporozoites from the in vitro tick feeding system sufficient to infect bovine lymphocytes in vitro. Lymphocytes were probed with anti-PIM monoclonal antibody. a Unstimulated and ConA-stimulated negative controls. b Flow cytometric detection of infected lymphocytes exposed to tenfold serial dilutions of T. parva sporozoites isolated from the in vitro tick feeding system
Fig. 4 in Isolation of infectious Theileria parva sporozoites secreted by infected Rhipicephalus appendiculatus ticks into an in vitro tick feeding system
Fig. 4 Demonstration of infectivity of secreted T. parva sporozoites collected from the in vitro tick feeding system. a Flow cytometric detection of cultured T. parva-infected lymphocytes. b Immunocytochemistry demonstrating T. parva schizont formation in bovine lymphocytes. Lymphocytes were probed with monoclonal antibodies: left panel, isotype control; right panel, anti-PIM. Red indicates antibody-specific reactivity to T. parva within bovine lymphocytes. Scale bar: 20 µm
Fig. 3 in Isolation of infectious Theileria parva sporozoites secreted by infected Rhipicephalus appendiculatus ticks into an in vitro tick feeding system
Fig. 3 Immunohistochemical detection of T. parva salivary gland acinus colonization in adult ticks. Tick sections were probed with monoclonal antibodies: a anti-PIM; b anti-p67; c isotype control. Red indicates antibody-specific reactivity to T. parva colonies. Scale bar: 50 µm
Fig. 1 in Isolation of infectious Theileria parva sporozoites secreted by infected Rhipicephalus appendiculatus ticks into an in vitro tick feeding system
Fig. 1 Infection of R. appendiculatus via acquisition feeding on a T. parva-infected calf. a Calf was infected via subcutaneous inoculation with T. parva salivary gland stabilate. The calf developed severe fever beginning 10 days post-infection. Red arrow indicates nymphal tick application and green arrows indicate collection of replete nymphs. b Detection of T. parva via p104 PCR. Amplicons were visualized in 2% agarose gel
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Chil
ClinicalTrials.gov study NCT03989102. IPD Sharing: NO. Countries: 1. Publications: 7.
Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers
ClinicalTrials.gov study NCT00367380. IPD Sharing: Not stated. Countries: 1. Publications: 69.
Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adu
ClinicalTrials.gov study NCT03510481. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults
ClinicalTrials.gov study NCT03162614. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccin
ClinicalTrials.gov study NCT03824236. IPD Sharing: YES. Countries: 1. Publications: 2.
Optimisation of Controlled Human Malaria Infection Using Sporozoites Administered by Needle and Syringe
ClinicalTrials.gov study NCT01465048. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Phase 1/2a Trial of Pf GAP p52-/p36- Sporozoite Malaria Vaccine
ClinicalTrials.gov study NCT01024686. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults
ClinicalTrials.gov study NCT01857869. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes
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Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
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Data from: Functional antibodies against Plasmodium falciparum sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso
Background: Individuals living in malaria-endemic regions develop naturally acquired immunity against severe malarial disease, but it is unclear whether immunity that affects the establishment of infections develops following continuous natural exposure. Methods: We cleared schoolchildren in Burkina Faso of possible sub-patent infections and examined them weekly for incident infections by PCR. Plasma samples collected at enrolment were used to quantify antibodies to the pre-eryhrocytic-stage antigens circumsporozoite protein (CSP) and liver stage antigen. Sporozoite gliding inhibition by naturally acquired antibodies was assessed using Plasmodium falciparum NF54 sporozoites; hepatocyte invasion was assessed using the human HC-04 hepatoma cell line and NF54 sporozoites. The associations between these functional pre-erythrocytic immunity phenotypes and time to PCR-detected infection were studied. Results: A total of 51 children were monitored; the median time to first detection of infection by PCR or development of clinical symptoms was 28 days. Anti-CSP antibody titres showed a strong positive association with sporozoite gliding motility inhibition (P<0.0001, Spearman's ρ=0.76). In vitro hepatocyte invasion was inhibited by naturally acquired antibodies (median invasion inhibition, 19.4% [IQR 15.2-40.9%]), and there was a positive correlation between gliding and invasion inhibition (P=0.02, Spearman's ρ=0.60). Survival analysis indicated longer time to infection in individuals displaying higher-than-median sporozoite gliding inhibition activity (P=0.01). Conclusions: In summary, functional antibodies against the pre-erythrocytic stages of malaria infection are acquired in children who are repeatedly exposed to Plasmodium parasites. This immune response does not prevent them from becoming infected during a malaria transmission season, but might delay the appearance of blood stage parasitaemia and consequently needs to be considered in the evaluation of malaria vaccines.
Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Ta
ClinicalTrials.gov study NCT02132299. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Coadministration of GA2 Sporozoites With Adjuvants
ClinicalTrials.gov study NCT05468606. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
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