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91 results for “sprague dawley”
Data from: Pulsed peritoneal dialysis in Sprague-Dawley rats
<p>Peritoneal dialysis treatment is hampered by low small solute clearances compared to hemodialysis. Previous data have indicated that stirring or mixing of the dialysate could possibly improve small solute diffusion, presumably by avoiding the formation of stagnant layers in the dialysate directly adjacent to the peritoneal membrane. In an experimental model of peritoneal dialysis in Sprague-Dawley rats, we compared a 60 min standard PD-exhange with a novel exchange technique called pulsed peritoneal dialysis in which the dialysate in pulsed in and out of the peritoneal cavity without the addition of fresh dialysis fluid. Samples of dialysate were taken directly after instillation and after 60 min. Samples of blood were taken before and after dialysis.</p>
Waxholm Space atlas of the Sprague Dawley Rat Brain V4.2 ASR - BigDataViewer Xml/Hdf5 File Format
<p>This dataset is the <a href="https://www.nitrc.org/projects/whs-sd-atlas/">Waxholm Space atlas of the Sprague Dawley Rat Brain V4 atlas</a> converted to a Fiji BigDataViewer compatible file format.</p> <p>To cite this dataset, please follow the <a href="https://www.nitrc.org/citation/?group_id=1081">citation policy of the authors of this atlas.</a></p> <p>Channels:</p> <ul> <li>T2star_v1.01 masked by the label image</li> <li>T2star_v1.01 full data</li> <li>LABELS BORDER, a channel generated by delineating the original labels</li> <li>LABELS, the label image of the atlas</li> </ul> <p>ilf file : ontology structure</p> <p>Compared to the previous version, the first channel is the result of the second channel masked by the presence of labels (last channel). This allows to use more easily automated registration methods.</p> <p>The version 4.1 had an issue with the left/right definition (but not the 4.0)</p> <p>https://forum.image.sc/t/help-for-abba-in-fiji-rat-atlas-tags-atlas-regions-on-both-hemispheres-as-belonging-to-the-right-hemisphere/83020</p> <p>The only modification between this version and the previous one is to use an ASR convention for the positioning in 3D. It will match exactly the BrainGlobe atlases.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
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Data from: Pulsed peritoneal dialysis in Sprague-Dawley rats
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Data from:Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and beagle dogs
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Effects of phloretin, ritonavir, indinavir and Bay-876 on glucose transport during peritoneal dialysis in Sprague-Dawley rats
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Experimental peritoneal dialysis in Sprague-Dawley rats using conventional or low sodium dialysis fluids
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Dataset- Chronic infusion of the tryptophan metabolite, kynurenine increases mean arterial pressure in male Sprague Dawley rats
<p>This dataset contains the supplemental figures 1 and 2 and supplemental tables 1 and 2 for the manuscript "Chronic infusion of the tryptophan metabolite, kynurenine increases mean arterial pressure in male Sprague Dawley rats."</p>
Effects of Aqueous Extract of Red Acalypha (Acalypha Wilkesiana) on Hippocampal Morphology and Memory in Sprague-Dawley Rats
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Data from: Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats
The longevity of pain after surgery is debilitating and limits the recovery of patients. AYX1 is a double-stranded, unprotected, 23 base-pair oligonucleotide designed to reduce acute post-surgical pain and prevent its chronification with a single intrathecal perioperative dose. AYX1 mimics the DNA sequence normally bound by EGR1 on chromosomes, a transcription factor transiently induced in the dorsal root ganglia—spinal cord network following a noxious input. AYX1 binds to EGR1 and prevents it from launching waves of gene regulation that are necessary to maintain pain over time. A formulation suitable for an intrathecal injection of AYX1 was developed, including a specific ratio of AYX1 and calcium so the ionic homeostasis of the cerebrospinal fluid is maintained and no impact on neuromuscular control is produced upon injection. A GLP toxicology study in naïve Sprague Dawley rats was conducted using 3 dose levels up to the maximum feasible dose. Clinical observations, neurobehavioral observations, clinical pathology and histopathology of the nervous system and peripheral tissues were conducted. An additional nonGLP study was conducted in the spared nerve injury model of chronic neuropathic pain in which EGR1 is induced in the dorsal root ganglia and spinal cord. Similar testing was performed, including a modified Irwin test to assess a potential impact of AYX1 on autonomic nervous system responses, locomotion, activity, arousal, sensorimotor, and neuromuscular function. No AYX1-related adverse events were observed in any of the studies and the no-observed-adverse-effect-level was judged to be the maximum feasible dose.
Effects of fluid overload on water and solute removal during peritoneal dialysis in Sprague-Dawley rats
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Data from: Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats
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In vivo transciptomic responses to bromobenzene exposure from liver and kidneys of Sprague Dawley rats
GEO Series GSE148852. Rattus norvegicus. 64 samples. Type: Expression profiling by high throughput sequencing.
In vitro transcriptomic responses to thioacetamide-S-oxide exposure in Sprague-Dawley rat primary hepatocytes, renal tube epithelial, and cardiomyocytes
GEO Series GSE134569. Rattus norvegicus. 90 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome sequencing and microRNA–mRNA regulatory network construction in the lens from a Na2Se03-induced Sprague Dawley rat cataract model [RNA]
GEO Series GSE226273. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of metabolic dysfunction in the aorta of male Sprague-Dawley rats following a short-term high fat diet
GEO Series GSE147335. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
RNAseq data of frontal cortex of Sprague Dawley rats expressing rat amylin (WT), human amylin (HIP), and rat amylin knock-out (AKO) rats
GEO Series GSE221450. Rattus norvegicus. 30 samples. Type: Expression profiling by high throughput sequencing.
microRNA profiling of Sprague Dawley organs
GEO Series GSE78031. Rattus norvegicus. 458 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats IV.
GEO Series GSE109016. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.