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179 results for “sputum”
A modified decontamination and storage method for sputum from patients with tuberculosis
<p>Sputum sampling is a cheap and non-invasive method for diagnosis Tuberculosis. A modified method is devised to enhance handling capacity and minimize risk of contamination in culture.</p> <p>"22_samples_TTP_GU_method_comparison_dataset.csv" is a dataset for comparing standard method and modified method of sputum handling and storing procedures before being cultured in MGIT. MGIT is used in BD BACTEC 960 MGIT system which generates "Time to positive" hours for a culture to growth and "Growth Unit" for estimating the amount of growth.</p> <p>"348_samples_TTP_GU_modified method_dataset.csv " is a dataset for applying modified method on selected 348 sputum samples for culture in MGIT. The dataset contains "Time to positive", "Growth Unit", "ZN smear grade", and "Duration of frozen:.</p>
Dataset from Remote analysis of Sputum Smears for Mycobacterium Tuberculosis Quantification using Digital Crowdsourcing
<p>Worldwide, TB is one of the top 10 causes of death and the leading cause from a single infectious agent. Although the development and roll out of Xpert MTB/RIF has recently become a major breakthrough in the field of TB diagnosis, smear microscopy remains the most widely used method for TB diagnosis, especially in low- and middle-income countries.</p> <p>This is a minimal dataset to reproduce our research that tests the feasibility of a crowdsourced approach to tuberculosis image analysis. In particular, we investigated whether anonymous volunteers with no prior experience would be able to count acid-fast bacilli in digitized images of sputum smears by playing an online game. Following this approach 1790 people identified the acid-fast bacilli present in 60 digitized images, the best overall performance was obtained with a specific number of combined analysis from different players and the performance was evaluated with the F1 score, sensitivity and positive predictive value, reaching values of 0.933, 0.968 and 0.91, respectively.</p> <p>The dataset includes 24 digitized images of sputum smears and the corresponding gameplays clicks. </p>
Data from: Use of the lung flute ECO to assist in sputum collection for tuberculosis testing: a randomized crossover trial
<p>The Lung Flute ECO, a self-powered, low cost, oscillatory positive expiratory pressure (OPEP) device, assisted people with presumptive tuberculosis to produce an adequate sputum volume for diagnostic testing and was well-tolerated.</p>
Second-line drug resistance markers as proxy indicators of sputum culture conversion for samples tested in Uganda
<p>Increased TB disease burden arises as a result of low treatment success rates stemming from the emergence of second-line drug (SLD) resistance. We aimed at determining the usefulness of SLD resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis (TB) treatment outcome, among SLD-resistant TB patients tested at the Uganda National TB Reference Laboratory (NTRL). A cross-sectional study was conducted on 72 bacteriologically confirmed SLDR TB patients with datasets including culture conversion time and second-line probe assay mutation profiles between 01/06/2017 and 31/12/2019. The data were then imported into STATA v15 for descriptive statistical analysis, Univariate cox proportional hazard model analysis and Kaplan-Meier survival curves at a 5% level of significance; p-value ≤ 0.05. Results indicate the median time was achieved at 3 (0–12) months across the studied patients. The <em>rrs</em> G1484T mutation associated with conferring drug resistance to aminoglycosides was observed to have the shortest median conversion time of 1.5 months and the longest by the <em>gryB</em> E540D at 5 months. A single mutation in the <em>gryA</em> gene locus showed higher converted proportions 70.8% (58.9–81.0) than those that had two 8.3% (3.1–17.3) or three 2.7% (0.3–10.0) mutations. We conclude that the studied second-line drug resistance markers had no statistically significant association with the time to sputum culture conversion, although increased drug resistance levels reduced the converted proportions and stressed the need to utilize molecular diagnostics data to better comprehend proxy indicators of SLD-resistant tuberculosis management.</p>
A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB)
ClinicalTrials.gov study NCT00685360. IPD Sharing: YES. Countries: 9. Publications: 1.
Effect of Symbicort ® on GR in Sputum in COPD
ClinicalTrials.gov study NCT01787097. IPD Sharing: NO. Countries: 1. Publications: 6.
A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects
ClinicalTrials.gov study NCT02522299. IPD Sharing: YES. Countries: 2. Publications: 1.
Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis
ClinicalTrials.gov study NCT00396084. IPD Sharing: Not stated. Countries: 2. Publications: 6.
Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients
ClinicalTrials.gov study NCT01112059. IPD Sharing: NO. Countries: 1. Publications: 1.
To Evaluate the Safety, Tolerability, and Efficacy of TMC207 as Part of an Individualized Multi-drug Resistant Tuberculosis (MDR-TB) Treatment Regimen in Participants With Sputum Smear-positive Pulmon
ClinicalTrials.gov study NCT00910871. IPD Sharing: Not stated. Countries: 12. Publications: 2.
Second-line drug resistance markers as proxy indicators of sputum culture conversion for samples tested in Uganda
Open the record for dataset details and reuse information.
Data from: Use of the lung flute ECO to assist in sputum collection for tuberculosis testing: a randomized crossover trial
Open the record for dataset details and reuse information.
Data from: Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused by larger shifts in the airways' microbiota. The aim of the current study was to analyse the changes in microbial composition between stable state and during exacerbations, and the corresponding immune response. Methods: The study sample included 36 COPD patients examined at stable state and exacerbation from the Bergen COPD Cohort and Exacerbations studies, and one patient who delivered sputum on 13 different occasions during the three-year study period. A physician examined the patients at all time points, and sputum induction was performed by stringent protocol. Only induced sputum samples were used in the current study, not spontaneously expectorated sputum. Sputum inflammatory markers (IL-6, IL-8, IL-18, IP-10, MIG, TNF-α) and antimicrobial peptides (AMPs, i.e. LL-37/hCAP-18, SLPI) were measured in supernatants, whereas target gene sequencing (16S rRNA) was performed on corresponding cell pellets. The microbiome bioinformatics platform QIIME2TM and the statistics environment R were applied for bioinformatics analyses. Results: Levels of IP-10, MIG, TNF-α and AMPs were significantly different between the two disease states. Of 36 sample pairs, 24 had significant differences in the 12 most abundant genera between disease states. The diversity was significantly different in several individuals, but not when data was analysed on a group level. The one patient case study showed longitudinal dynamics in microbiota unrelated to disease state. Conclusion: Changes in the sputum microbiota with ch anging COPD disease states are common, and are accompanied by changes in inflammatory markers. However, the changes are highly individual and heterogeneous events.
Lymphocytes Cut Off Values of Induced Sputum Samples in Healthy and Non-healthy Patients- A Cross Sectional Study
ClinicalTrials.gov study NCT02093936. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Intrapulmonary Percussive Ventilation for Sputum Induction in Adults With Cystic Fibrosis
ClinicalTrials.gov study NCT06311292. IPD Sharing: NO. Countries: 1. Publications: 0.
Sputum Pharmacokinetics of TB Drugs and Bacterial Drug Resistance
ClinicalTrials.gov study NCT02534727. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 1.
ClinicalTrials.gov study NCT01224938. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Safety and Efficacy of QAW039 in Sputum Eosinophilia and Persistent Asthma
ClinicalTrials.gov study NCT01545726. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mucin Concentration in Sputum From COPD Patients During a Pulmonary Exacerbation
ClinicalTrials.gov study NCT01848093. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Visual Sputum Suctioning System Tests in Mechanically Ventilated Patients
ClinicalTrials.gov study NCT02116491. IPD Sharing: Not stated. Countries: 1. Publications: 6.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.