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Dataset results
50 results for “steroid receptors”
Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Meta
ClinicalTrials.gov study NCT02069093. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Association of Tumour Grade and Sex Steroid Receptor as a Prognostic Index in Breast Cancer
ClinicalTrials.gov study NCT04707287. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma
ClinicalTrials.gov study NCT01805453. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Outcome of the Thrombopoietin Receptor Agonists in Pediatric Patient With Persistent or Chronic ITP Unresonsive to Steroids
ClinicalTrials.gov study NCT06568913. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Leukotriene Receptor Antagonists or Steroids in Pre-School Asthma
ClinicalTrials.gov study NCT00543686. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Expression of Steroid Receptors in Endometrium
ClinicalTrials.gov study NCT00436462. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Perturbing the cellular cevels of steroid receptor coactivator-2 impairs murine endometrial function
As pleiotropic coregulators, members of the p160/steroid receptor coactivator (SRC) family control a broad spectrum of transcriptional responses that underpin a diverse array of physiological and pathophysiological processes. Because of their potent coregulator properties, strict controls on SRC expression levels are required to maintain normal tissue functionality. Accordingly, an unwarranted increase in the cellular levels of SRC members has been causally linked to the initiation and/or progression of a number of clinical disorders. Although knockout mouse models have underscored the critical non-redundant roles for each SRC member in vivo, there are surprisingly few mouse models that have been engineered to overexpress SRCs. This deficiency is significant since SRC involvement in many of these disorders is based on unscheduled increases in the levels (rather than the absence) of SRC expression. To address this deficiency, we used recent mouse technology that allows for the targeted expression of human SRC-2 in cells which express the progesterone receptor. Through cre-loxP recombination driven by the endogenous progesterone receptor promoter, a marked elevation in expression levels of human SRC-2 was achieved in endometrial cells that are positive for the progesterone receptor. As a result of this increase in coregulator expression, female mice are severely subfertile due to a dysfunctional uterus, which exhibits a hypersensitivity to estrogen exposure. Our findings strongly support the proposal from clinical observations that increased levels of SRC-2 are causal for a number of endometrial disorders which compromise fertility. Future studies will use this mouse model to decipher the molecular mechanisms that underpin the endometrial defect. We believe such mechanistic insight may provide new molecular descriptors for diagnosis, prognosis, and/or therapy in the clinical management of female infertility.
Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase Inhibitors
ClinicalTrials.gov study NCT01225172. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Perturbing the cellular cevels of steroid receptor coactivator-2 impairs murine endometrial function
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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
GEO Series GSE104399. Homo sapiens. 86 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide map of long non-coding RNA steroid receptor RNA activator (SRA) and its associated RNA heliase p68 in human pluripotent stem cells NTERA2
GEO Series GSE58641. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hormone Control Regions mediate steroid receptor-dependent genome organizations
GEO Series GSE109229. Homo sapiens. 60 samples. Type: Other.
C/EBP Maintains Chromatin Accessibility in Liver and Facilitates Glucocorticoid Receptor Recruitment to Steroid Response Elements
GEO Series GSE46047. Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Steroid Receptor Coactivator-2 Controls Human Extravillous Trophoblast Cell Proliferation, Migration, and Invasion
GEO Series GSE278677. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Steroid Receptor Coactivator-2 Regulated Transcriptome in Human Endometrial Stromal Cells
GEO Series GSE121584. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A Steroid Receptor Coactivator Stimulator (MCB-613) Prevents Adverse Remodeling After Myocardial Infarction
GEO Series GSE157542. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
GEO Series GSE104730. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Quantitative Analysis of steroid receptor RNA activator (SRA1) Transcriptomes
GEO Series GSE74461. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Steroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress
GEO Series GSE246877. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Targeting steroid receptor co-activator 3 sensitizes myeloma cell to proteasome inhibitor treatment through NSD2-mediated phase separation and chromatin remodeling [RNA-Seq]
GEO Series GSE156871. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.