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37 results for “stress axis”
Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
<p><strong><span>Scope:</span></strong><span> Evidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice.</span></p> <p><strong><span>Methods and Results:</span></strong><span> In this study, ATX as dose of 0.25%, 0.5% and 0.75% have orally administered to mice along with a high-fat diet (HFD) to investigate the role of ATX in regulating liver lipid metabolism and gut microbiota. The study showed that ATX dose-dependently reduces body weight, lipid droplet formation, hepatic triglycerides and ameliorated hepatic steatosis and oxidative stress. 0.75% ATX altered the levels of 34 lipid metabolites related to hepatic cholesterol and fatty acid metabolism which might be associated with downregulation of lipogenesis-related genes and upregulation of bile acid biosynthesis-related genes. The result also revealed that ATX alleviates HFD-induced gut microbiota dysbiosis by significantly inhibiting the growth of obesity-related <em>Parabacteroides</em> and <em>Desulfovibrio</em> while promoting the growth of <em>Allobaculum</em> and <em>Akkermansia</em>. </span></p> <p><span><strong>Conclusion:</strong> The study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.</span></p>
Stress axis programming generates long-term effects on cognitive abilities in a cooperative breeder
<p><span>The ability to flexibly adjust behaviour to social and non-social challenges is important for successfully navigating variable environments. Social competence, i.e., adaptive behavioural flexibility in the social domain, allows individuals to optimize their expression of social behaviour. Behavioural flexibility outside the social domain aids in coping with ecological challenges. However, it is unknown if social and non-social behavioural flexibility share common underlying cognitive mechanisms. Support for such shared mechanism would be provided if the same neural mechanisms in the brain affected social and non-social behavioural flexibility similarly. We used individuals of the cooperatively-breeding fish <em>Neolamprologus pulcher</em> that had undergone early-life programming of the hypothalamic-pituitary-interrenal (HPI) axis by exposure to (i) cortisol, (ii) the glucocorticoid-receptor antagonist mifepristone or (iii) control treatments, and where effects of stress-axis programming on social flexibility occurred. One year after the treatments, adults learned a colour-discrimination task, and subsequently, a reversal-learning task testing for behavioural flexibility. Early-life mifepristone treatment only marginally affected learning performance, whereas cortisol treatment significantly reduced behavioural flexibility. Thus, early-life cortisol treatment reduced both social and non-social behavioural flexibility, suggesting a shared cognitive basis of behavioural flexibility. Further our findings imply that early-life stress programming affects the ability of organisms to flexibly cope with environmental stressors.</span></p>
Senescence and the stress axis in male ground squirrels
<p>A critical time in the life of a male occurs at reproduction when his behavior, physiology, and resources must be brought to bear for the central purpose of his life. We ask whether reproduction results in dysfunction of the stress axis, is linked to life history, and causes senescence. We assessed if deterioration in the axis underlies variation in reproductive lifespan in males of 5 species of North American ground squirrels whose life history varies from near semelparity to iteroparity. The most stressful and energy-demanding time occurs in spring during the intense 2–3 week breeding competition just after arousal from hibernation. We compared their stress axis functioning before and after the mating period using a hormonal challenge protocol. We found no evidence of stress axis dysfunction nor was there a relationship between reproductive lifespan and stress axis functional deterioration. Moreover, there was no consistent relationship between free cortisol levels and downstream measures. Thus, stress axis function was not traded off to promote reproduction and conclude that it is a pre-requisite for life. Hence, it functions as a constraint and does not undergo senescence.</p>
Senescence and the stress axis in male ground squirrels
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Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
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Stress axis programming generates long-term effects on cognitive abilities in a cooperative breeder
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Data from: Sex-biased transcriptomic response of the reproductive axis to stress
Stress is a well-known cause of reproductive dysfunction in many species, including birds, rodents, and humans, though males and females may respond differently. A powerful way to investigate how stress affects re- production is by examining its effects on a biological system essential for regulating reproduction, the hy- pothalamic-pituitary-gonadal (HPG) axis. Often this is done by observing how a stressor affects the amount of glucocorticoids, such as cortisol or corticosterone, circulating in the blood and their relationship with a handful of known HPG-producing reproductive hormones, like testosterone and estradiol. Until now, we have lacked a full understanding of how stress affects all genomic activity of the HPG axis and how this might differ between the sexes. We leveraged a highly replicated and sex-balanced experimental approach to test how male and female rock doves (Columba livia) respond to stress at the level of their transcriptome. Females exhibit increased genomic responsiveness to stress at all levels of their HPG axis as compared to males, and these responsive genes are mostly unique to females. Reasons for this may be due to fluctuations in the female endocrine environment over the reproductive cycle and/or their evolutionary history, including parental investment and the potential for maternal effects. Direct links between genome to phenome cause and effect cannot be ascertained at this stage; however, the data we report provide a vital genomic foundation on which sex-specific reproductive dysfunction and adaptation in the face of stress can be further experimentally studied, as well as novel gene targets for genetic intervention and therapy investigations.
Vitamin D3 and the Stress-axis in MS
ClinicalTrials.gov study NCT02096133. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT00921492. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Sex-biased transcriptomic response of the reproductive axis to stress
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Data from: Individual variation in phenotypic plasticity of the stress axis
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Data from: Stress effects on mood, HPA axis, and autonomic response: comparison of three psychosocial stress paradigms
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Long-term measures of climate unpredictability shape the avian endocrine stress axis
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Endoplasmic reticulum stress sensor protein PERK in hepatic stellate cells promotes the progression of hepatocellular carcinoma via p38δ MAPK/IL-1β axis
GEO Series GSE292002. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of miRNA expression profiles in pituitary–adrenal axis between Beagle and Chinese Field dogs after chronic stress exposure
GEO Series GSE72015. Canis lupus familiaris. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis
GEO Series GSE274949. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR/Cas9 gene editing in Hematopoietic Stem and Progenitor Cells
GEO Series GSE238189. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Repressed Blautia-acetate immunological axis underlies chronic stress promoted breast cancer progression
GEO Series GSE231961. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis
GEO Series GSE237795. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A stress response axis in tumor-associated macrophages dictates phenotype heterogeneity and immunotherapy evasion
GEO Series GSE290434. Mus musculus. 21 samples. Type: Other; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.