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8 results for “structure-function relationship”
Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome
<p>Dataset linked to the article with the same title</p> <p>The model itself is very similar to its non-plastic counterpart under the following DOI: <a href="../record/7930275">10.5281/zenodo.7930275</a>, i.e. a 1.5 mm diameter cortical tissue comprising 211,712 neurons and their connectivity in the front limb and jaw subregions and the dysgranular zone of the Paxinos & Watson rat brain atlas. It's formatted in the open <a href="https://github.com/AllenInstitute/sonata">SONATA</a> standard and contains neuron locations and their properties (such as morphological types, cortical layer, etc.), their detailed morphologies, and synaptic connectivity (with all their anatomical and physiological parameters). The main difference from the non-plastic version is the addition of plasticity related parameters to <em>O1/S1nonbarrel_neurons__S1nonbarrel_neurons__chemical/edges.h5. </em>Extrinsic synaptic connections from the thalamus are included in this release, but for inputs from neurons in the remainder of non-barrel somatosensory cortex please see the non-plastic version of the circuit.</p> <p><strong>Analyzing the model</strong></p> <p>The model can be analyzed in terms of its anatomy, physiology and connectivity using the packages <a href="https://neurom.readthedocs.io/en/stable/">NeuroM</a>, <a href="https://bluebrainsnap.readthedocs.io/en/stable/">BlueBrain SNAP</a> and <a href="https://github.com/BlueBrain/ConnectomeUtilities">ConnectomeUtilities</a>. (see first Jupyter notebook)</p> <p><strong>Simulating the model</strong></p> <p>To simulate the model we'd recommend using out using our open-source simulator <a href="https://github.com/BlueBrain/neurodamus">Neurodamus</a>. The reference version is the branch <em>nbS1-2023</em>, which is archived under the following DOI: <a href="http://doi.org/10.5281/zenodo.8075202">10.5281/zenodo.8075202</a>. Instructions on how to use the simulator are provided on the GitHub page linked above. Briefly, you'll first have to <a href="https://github.com/BlueBrain/neurodamus#install-neurodamus">install Neurodamus</a>. Next, build a <em>"special"</em> executable that include compiled versions of ion channel and synapse models. To do that, follow <a href="https://github.com/BlueBrain/neurodamus#build-special-with-mod-files">these instructions</a>, where <em>mod-files-from-released-circuit </em>is replaced by the location of <em>O1/mods</em> on your system. Finally, <a href="https://github.com/BlueBrain/neurodamus#examples">run a simulation</a>. The specific simulation conditions and stimuli are specified in simulation configuration files. An exemplary simulation configuration is included in this release (<em>simulation_config.zip</em>).</p> <p><strong>Analyzing simulation results</strong></p> <p>Simulation results can be analyzed with <a href="https://bluebrainsnap.readthedocs.io/en/stable/">BlueBrain SNAP</a>, <a href="https://github.com/BlueBrain/ConnectomeUtilities">ConnectomeUtilities</a>, and <a href="https://github.com/BlueBrain/assemblyfire">assemblyfire</a>. Notebooks 2-5 go though these analysis and recreate some of the panels from our article. In most cases the notebooks can be run with the shared HDF5 files and don't require running any simulations.</p> <p><strong>Version 2</strong></p> <p>Bug fix in simulation_config.json and therefore new version of results (and corresponding notebooks). The underlying circuit model (O1.xz) did not change from v1.</p> <p>--</p> <p><em>The development of this dataset was supported by funding to the Blue Brain Project, a research center of the École polytechnique fédérale de Lausanne (EPFL), from the Swiss government’s ETH Board of the Swiss Federal Institutes of Technology.</em></p>
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
<p>The multi-subunit bacterial RNA polymerase (RNAP) and its associated regulators carry out transcription and integrate myriad regulatory signals. Numerous studies have interrogated the inner workings of RNAP, and mutations in genes encoding RNAP drive adaptation of <i>Escherichia coli</i> to many health- and industry-relevant environments, yet a paucity of systematic analyses has hampered our understanding of the fitness benefits and trade-offs from altering RNAP function. Here, we conduct a chemical-genetic analysis of a library of RNAP mutants. We discover phenotypes for non-essential insertions, show that clustering mutant phenotypes increases their predictive power for drawing functional inferences, and demonstrate that some RNA polymerase mutants both decrease average cell length and confer insensitivity to killing by cell-wall targeting antibiotics. Our findings demonstrate that RNAP chemical-genetic interactions provide a general platform for interrogating structure-function relationships <i>in vivo</i> and for identifying physiological trade-offs of mutations, including those relevant for disease and biotechnology. This strategy should have broad utility for illuminating the role of other important protein complexes.</p>
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
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Supplementary material and dataset for article "Structure-Function Relationship of Iron Oxide Nanoflowers: Optimal Sizes for Magnetic Hyperthermia Depending on Alternating Magnetic Field Conditions"
<p>The supporting information file contains additional measurements compared to the main manuscript of the related article: TEM size histograms, SAED and XRD patterns, absorption and fluorescence spectra, DC magnetization curves, AC hysteresis loops, HR-TEM, their FTT patterns and inverse FFT images after applying a mask in the reciprocal space, and various other plots of this multi-parametric study on the structure-properties relations of magnetic iron oxide nanoflowers. Whenever needed for comparison to other experimental results or theoretical fitting, the raw data of all DC magnetization curves, AC hysteresis loops, ZFC-FC magnetization curves vs. temperature (and their derivatives on temperature) are made freely available in this dataset.</p>
Data from: Describing complex structure-function relationships in biomolecules at equilibrium
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Dataset related to "A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations"
<p>This is an accompanying dataset to the article with the title "A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations" (DOI: <a href="https://doi.org/10.1162/netn_a_00429" target="_blank" rel="noopener">10.1162/netn_a_00429</a>). It contains the resulting data of the manipulated SSCx network model, such as benchmarks, fitted stochastic models, manipulated connectomes, structural validations, as well as simulation data and analysis results.</p> <p>The corresponding repository with code, configuration files, and detailed instructions for reproducing the results in this dataset as well as generating the results figures in the accompanying article is available here: <a href="https://github.com/BlueBrain/sscx-connectome-manipulations" target="_blank" rel="noopener">https://github.com/BlueBrain/sscx-connectome-manipulations</a></p> <p>The underlying <em>Connectome-Manipulator</em> software is available here: <a href="https://github.com/BlueBrain/connectome-manipulator" target="_blank" rel="noopener">https://github.com/BlueBrain/connectome-manipulator</a></p> <p>Additional requirement: Original SSCx network model (DOI: <a href="https://doi.org/10.5281/zenodo.8026353" target="_blank" rel="noopener">10.5281/zenodo.8026353</a>)</p> <p>ℹ️ Disclaimer: Some results may have been produced with an older version of <em>Connectome-Manipulator</em>, so slight differences might be possible when re-running with the latest version.</p> <p><strong>Update 25/09/2024 (v2):</strong> Added benchmark results for assessing strong and weak scaling behavior of connectome rewiring.</p> <blockquote> <p><strong><em>Funding</em></strong></p> <p><em>Funding provided by the Swiss government’s ETH Board to the Blue Brain Project, a research center of the École polytechnique fédérale de Lausanne (EPFL).</em></p> </blockquote>
Supplementary Data for "Exploring structure-function relationships in engineered receptor performance using computational structure prediction"
<p>These data are supplementary data for the manuscript "<strong>Exploring structure-function relationships in engineered receptor performance using computational structure prediction</strong>", which has been submitted for consideration for publication. These data include protein structure predictions used in this study.</p>
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation
GEO Series GSE199438. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.