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66 results for “subthalamic nucleus”
Principles of gait encoding in the subthalamic nucleus of people with Parkinson's disease
<p>Disruption of subthalamic nucleus dynamics in Parkinson’s disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson’s disease. We conceived a neurorobotic platform embedding an isokinetic dynamometric chair that allowed us to deconstruct key components of walking under well-controlled conditions. We exploited this platform in 18 patients with Parkinson’s disease to demonstrate that the subthalamic nucleus encodes the initiation, termination, and amplitude of leg muscle activation. We found that the same fundamental principles determine the encoding of leg muscle synergies during standing and walking. We translated this understanding into a machine learning framework that decoded muscle activation, walking states, locomotor vigor, and freezing of gait. These results expose key principles through which subthalamic nucleus dynamics encode walking, opening the possibility to operate neuroprosthetic systems with these signals to improve walking in people with Parkinson’s disease.</p>
Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
<p>The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson's disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Further, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.</p>
Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus
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Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus
<p>Supporting information for PLOS ONE article titled "Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus" by Nguyen et al. (2019)</p>
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
ClinicalTrials.gov study NCT01076452. IPD Sharing: Not stated. Countries: 1. Publications: 6.
The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease
ClinicalTrials.gov study NCT05905302. IPD Sharing: NO. Countries: 1. Publications: 1.
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
ClinicalTrials.gov study NCT04383665. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus
ClinicalTrials.gov study NCT01721460. IPD Sharing: NO. Countries: 1. Publications: 1.
Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making
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Data from: Mapping movement, mood, motivation, and mentation in the subthalamic nucleus
The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across Parkinson disease (PD) patients. We previously tested that hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact. Here we report a similar analysis from a new study in which DBS parameters were standardized and DBS locations were chosen blind to clinical response. In 74 individuals with PD and STN DBS, STN contacts were selected near the dorsal and ventral border of the STN contralateral to the more affected side of the body. Participants were tested off PD medications in each of 3 unilateral DBS conditions (ventral STN DBS, dorsal STN DBS and DBS off) for acute effects on mood, apathy, working memory, response inhibition and motor function. Voltage, frequency, and pulse width were standardized, and participants and raters were blind to condition. In a categorical analysis, both dorsal and ventral STN DBS improved mean motor function without affecting cognitive measures. Ventral STN DBS induced greater improvement in rigidity and anxiety than dorsal STN DBS. In the 3D analysis, contact location was significant for body hypokinesia, rigidity, and resting tremor, with the greatest improvement occurring with DBS in dorsal STN and zona incerta. The 3D results provide new, direct functional evidence for the anatomically-derived model of STN, in which motor function is best represented in dorsal STN. However, our data suggest that functional segregation between motor and non-motor areas of the STN is limited, since locations that induced improvements in motor function and mood overlapped substantially.
Impact of Deep Brain Stimulation of Subthalamic Nucleus on the Hepatic Glucose Production in Parkinson's Disease
ClinicalTrials.gov study NCT00663312. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation (DBS) For Parkinson's Disease: Caudal Zona Incerta Versus Subthalamic Nucleus
ClinicalTrials.gov study NCT00888095. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Subthalamic Nucleus (STN) Stimulation and Obsessive-Compulsive Disorder (OCD)
ClinicalTrials.gov study NCT00169377. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Subthalamic Nucleus Stimulation With Directional Leads on Patients With Parkinson Disease at Fluctuations and Dyskinesia Stage
ClinicalTrials.gov study NCT05103072. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety Study of Subthalamic Nucleus Gene Therapy for Parkinson's Disease
ClinicalTrials.gov study NCT00195143. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait
ClinicalTrials.gov study NCT02704195. IPD Sharing: NO. Countries: 1. Publications: 1.
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
ClinicalTrials.gov study NCT06685510. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease
ClinicalTrials.gov study NCT00643890. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Subthalamic Nucleus Versus Globus Pallidal Internus Deep Brain Stimulation for Parkinson Disease
ClinicalTrials.gov study NCT07250685. IPD Sharing: NO. Countries: 1. Publications: 9.
STIMEP : Assessment of Subthalamic Nucleus Stimulation in Drug Resistant Epilepsy
ClinicalTrials.gov study NCT00228371. IPD Sharing: Not stated. Countries: 1. Publications: 9.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.